The BioSUD Biobank: A genomic resource for Substance Use Disorders in Italy DOI Creative Commons
Raffaella Maria Ribatti, Luciana de Gennaro, Alessia Daponte

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

Abstract Substance Use Disorders (SUDs) are a significant public health concern with complex etiologies involving genetic, environmental, and psychological factors. Here we present BioSUD, biobank that, by integrating genomic data comprehensive phenotypic assessments, including sociodemographic, psychosocial, addiction-related variables, was developed to investigate the etiology of SUDs within Southern Italian population. We assessed cohort 1,806 participants (1,508 controls 298 individuals SUD diagnosis), revealing marked male predominance in both groups. Genomic analyses newly generated genotypes showed predominantly ancestry for BioSUD cohort. Moreover, multiple genotype analysis highlights presence different ancestries, suggesting history groups, contributing relatively high level genetic variation that may be not captured translational studies based on groups Northern European ancestries. From social perspective, exhibited lower socioeconomic status, increased exposure adverse experiences, compromised familial peer relationships relative controls. These results show is valuable studying SUDs-associated behavioral traits.

Язык: Английский

Combining Transdiagnostic and Disorder-Level GWAS Enhances Precision of Psychiatric Genetic Risk Profiles in a Multi-Ancestry Sample DOI Creative Commons
Yousef Khan, Christal N. Davis, Zeal Jinwala

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 10, 2024

Abstract The etiology of substance use disorders (SUDs) and psychiatric reflects a combination both transdiagnostic (i.e., common) disorder-level independent) genetic risk factors. We applied genomic structural equation modeling to examine these factors across SUDs, psychotic, mood, anxiety using genome-wide association studies (GWAS) European-(EUR) African-ancestry (AFR) individuals. In EUR individuals, represented SUDs (143 lead single nucleotide polymorphisms [SNPs]), psychotic (162 SNPs), mood/anxiety (112 SNPs). identified two novel SNPs for that have probable regulatory roles on FOXP1 , NECTIN3 BTLA genes. AFR (1 SNP) (no significant SUD factor SNP, although previously in EUR- cross-ancestry GWAS, is finding Shared variance accounted overlap between their comorbidities, with second-order GWAS identifying up 12 not significantly associated either first-order Finally, common independent effects showed different associations psychiatric, sociodemographic, medical phenotypes. For example, the components schizophrenia bipolar disorder had distinct affective risk-taking behaviors, phenome-wide conditions tobacco broader factor. Thus, combining approaches can improve our understanding co-occurring increase specificity discovery, which critical demonstrate considerable symptom etiological overlap.

Язык: Английский

Процитировано

5
Exome sequencing identifies protein-coding variants associated with loneliness and social isolation DOI
Yixuan Wang,

Chen-Jie Fei,

Chun Shen

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Loneliness in South African youth and its association with HIV infection, substance use and mental health DOI Creative Commons

Gabriella N. Stein,

Nicole Phillips,

Mothabisi N. Nyathi

и другие.

International Journal of Adolescence and Youth, Год журнала: 2025, Номер 30(1)

Опубликована: Апрель 24, 2025

Язык: Английский

Процитировано

0
The health consequences of loneliness DOI Open Access
Ami Rokach, Karishma Patel

Environment and Social Psychology, Год журнала: 2024, Номер 9(6)

Опубликована: Март 12, 2024

In this paper, through a thematic literature review of recent studies, our objective was to explore the impact loneliness and its effects on health. We emphasize human need for sense belonging societal inclusion. further discuss link physiological alterations, development exacerbation mental health conditions, influence it has cognitive processes, role plays in contributing maladaptive coping strategies. Contrary feelings loneliness, solitude benefits self-reflection personal growth are explored. The prevalence cultural similarities differences discussed at global level. Moreover, explores intricate relationship between various outcomes, including chronic illness mortality risks. It emphasizes importance acknowledging as public concern interventions individual level mitigate adverse effects.

Язык: Английский

Процитировано

2
The BioSUD Biobank: A genomic resource for Substance Use Disorders in Italy DOI Creative Commons
Raffaella Maria Ribatti, Luciana de Gennaro, Alessia Daponte

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

Abstract Substance Use Disorders (SUDs) are a significant public health concern with complex etiologies involving genetic, environmental, and psychological factors. Here we present BioSUD, biobank that, by integrating genomic data comprehensive phenotypic assessments, including sociodemographic, psychosocial, addiction-related variables, was developed to investigate the etiology of SUDs within Southern Italian population. We assessed cohort 1,806 participants (1,508 controls 298 individuals SUD diagnosis), revealing marked male predominance in both groups. Genomic analyses newly generated genotypes showed predominantly ancestry for BioSUD cohort. Moreover, multiple genotype analysis highlights presence different ancestries, suggesting history groups, contributing relatively high level genetic variation that may be not captured translational studies based on groups Northern European ancestries. From social perspective, exhibited lower socioeconomic status, increased exposure adverse experiences, compromised familial peer relationships relative controls. These results show is valuable studying SUDs-associated behavioral traits.

Язык: Английский

Процитировано

0