Infant development at 14 months in the context of maternal objective and subjective birth experience and infant hair glucocorticoids

BMC Pediatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Март 14, 2025

Abstract Background Evidence suggests maternal birth experience impacts infant health. Alterations of the infant’s hypothalamus-pituitary-adrenal (HPA) axis are discussed as one possible underlying mechanism. This study aimed to investigate both objective and subjective potential predictors offspring’s hair glucocorticoid concentrations (GCs) development, respectively. Further, we examined role GCs for prospective development in different domains. Methods n = 263 mothers participating cohort DREAM HAIR completed questionnaires about their approximately eight weeks after birth. Additionally, samples from 286 infants were taken around ten days (neonatal GCs) (infant long-term integrated cortisol cortisone levels measured scalp-near 2-cm segments. Infant (communication, gross motor, fine problem-solving, personal-social) was assessed 14 months using Ages Stages Questionnaire − 3 (ASQ-3). Results No significant associations found between or most domains except that a more negative predicted poorer motor skills. linked lower higher cortisol/cortisone ratio, while associated with neonatal cortisol. Lower showed link personal-social development. However, correction multiple testing, only ratio at remained significant. Conclusions Objective aspects may have enduring impact on than perceptions, particularly complications being ratio. Given this indicate reduced enzymatic activity converting its inactive form, results suggest could affect metabolism. robust experiences Further research diverse, at-risk populations is needed clarify these complex relationships.

Язык: Английский

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Longitudinal effects of maternal depressive and anxious symptomatology on child hair cortisol and cortisone from pregnancy to 5-years: The EDEN mother-child cohort

Psychoneuroendocrinology, Год журнала: 2024, Номер 162, С. 106957 - 106957

Опубликована: Янв. 11, 2024

Exposure to maternal depressive and anxious symptomatology in utero after birth can affect child outcomes. One proposed mechanism is through changes stress hormone levels, however current studies present inconsistent findings, further research needed better understand the impact of mental health on response. This study aims add limited literature by analysing longitudinal data ranging from 24 weeks amenorrhea 5 years postpartum among 281 mother-child pairs French EDEN cohort. Hair cortisol cortisone were collected children at four time points: birth, 1, 3, years. Mothers reported via Center for Epidemiologic Studies Depression Scale (CES-D) (at 24-weeks amenorrhea, 3-, 5-year follow-up), Edinburgh Postnatal (EPDS) 4, 8 12 months postpartum). Prenatal anxiety was measured State Anxiety Inventory (STAI) amenorrhea. Group-based trajectory modelling indicated a 1-cluster classification hair cortisol, cortisol-to-cortisone ratio, as analyses did not reveal subgroups representing different profiles. After inverse probability weighting, small effects showed prenatal significantly associated higher levels one year. linked 1 Postpartum related 3-year-olds. These moderated sex or socio-economic status. Further why there are associations some points others determine any potential buffering factors.

Язык: Английский

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Come gli stati psichici si traducono in molecole biologiche e come questo cambia la medicina e la psicologia

PSICOTERAPIA E SCIENZE UMANE, Год журнала: 2023, Номер 1, С. 107 - 128

Опубликована: Фев. 1, 2023

Nell'aprile del 2022 abbiamo pubblicato, su invito di una rivista internazionale biologia molecolare, un'ampia review che riporta le principali evidenze scientifiche sul tema delle relazioni tra vita psichica e biologia, traendone alcune conclusioni carattere generale sulla psicologia la medicina (Bottaccioli, Bologna & Bottaccioli, 2022). Il presente articolo riprende alcuni dei passaggi fondamentali presentati in quella si collega a un precedente pubblicato n. 4/2014 Psicoterapia Scienze Umane 2014b), cui rappresenta aggiornamento. Dalla pubblicazione quell'articolo sperimentali cliniche sull'influenza della psiche sui sistemi biologici sono moltiplicate. Al tempo stesso, conosciamo meglio vie i meccanismi con gli stati psichici traducono biologia.

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The Impact of Working Conditions on Postpartum Depressive Symptoms and Family Relations: Re-evaluated in Light of the COVID-19 Pandemic

Опубликована: Дек. 9, 2023

There are indications that working conditions play a role in postpartum mental health and family relations. These include precarious conditions, psychosocial work stress, work-privacy conflict. However, these findings mainly come from cross-sectional studies conducted the United States. To further investigate first indications, Dresden Study on Parenting, Work, Mental Health (DREAM) was developed. It is German, longitudinal, multi-method cohort study. DREAM has various sub-studies, including DREAMCORONA DREAMCORONA-TALK, developed to experiences of (expectant) parents during COVID-19 pandemic (e.g., isolation, school daycare closures, home) its impact relationships. With can compare related outcomes families before pandemic. results revealed most pre-pandemic issues stayed relevant For instance, stress identified as risk factor for depression, both Additionally, new like higher prevalence which shown have negative parent-child bonding Regarding parents' relationship satisfaction, we found no decrease times up second wave December 2020. Moreover, gender equal distributions facilitate mothers' satisfaction. summarize, showed what work-related factors need be addressed support happiness, after

Язык: Английский

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Stability and inter-family associations of hair endocannabinoid and N-acyl-ethanolamines across the perinatal period in mothers, fathers, and children

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Янв. 9, 2024

Analysis of endocannabinoids (ECs) and endocannabinoid-related compounds (ERCs) in hair is assumed to retrospectively assess long-term EC/ERC concentrations. To inform their use, this study investigated stability concentrations mothers, fathers, children across the perinatal period as well associations between family members. In a prospective cohort study, EC (AEA, 1-AG/2-AG) ERC (SEA, PEA, OEA) levels were quantified samples taken four times mothers (n =336)and partners =225) from pregnancy two years postpartum offspring =319) shortly after birth postpartum. Across period, maternal paternal ECs/ERCs showed fair-to-good multiple-test consistency variable relative stability, inconsistent absolute for mothers. Regarding children, evidenced poor consistency, no either or stability. Hair significantly related within couples parent-child dyads. Findings suggest during possess some trait-like adults, highlighting utility analysis. The first life may be dynamic phase endocannabinoid system potentially characterized by synchrony family.

Язык: Английский

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Hair cortisol stability after 5-year storage: Insights from a sample of 17-year-old adolescents

Comprehensive Psychoneuroendocrinology, Год журнала: 2024, Номер 18, С. 100234 - 100234

Опубликована: Апрель 17, 2024

Hair has become an increasingly valuable medium to investigate the association between chronic stress, stable differences in systemic cortisol secretion and later health. Assessing hair many advantages, notably its non-invasive retrospective nature, need for a single biospecimen convenient storage until analysis. However, few studies offered empirical evidence documenting long-term temporal stability of concentration (HCC) prior analysis, especially humans. Yet, knowing how long samples can be stored without compromising accuracy measurement is crucial importance when planning data collection This study examined HCC assayed twice, five years apart.

Язык: Английский

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Stability and inter-family associations of hair endocannabinoid and N-acylethanolamines across the perinatal period in mothers, fathers, and children

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 24, 2024

Analysis of endocannabinoids (ECs) and N-acylethanolamines (NAEs) in hair is assumed to retrospectively assess long-term EC/NAE concentrations. To inform their use, this study investigated stability concentrations mothers, fathers, children across the perinatal period as well associations between family members. In a prospective cohort study, EC (AEA, 1-AG/2-AG) NAE (SEA, PEA, OEA) levels were quantified samples taken four times mothers (n = 336) partners 225) from pregnancy two years postpartum offspring 319) shortly after birth postpartum. Across period, maternal paternal ECs/NAEs showed poor multiple-test consistency (16-36%) variable relative stability, inconsistent absolute for mothers. Regarding children, evidenced (4-19%), no either or stability. Hair small medium significant within couples parent-child dyads. Findings suggest during possess adults, albeit more fathers than time. This highlights need further investigate factors associated with changes The first life may be dynamic phase endocannabinoid system potentially characterized by complex within-family correspondence that requires systematic investigation.

Язык: Английский

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Toddler hair cortisol levels are associated with maternal prenatal depression

American Journal of Human Biology, Год журнала: 2024, Номер 36(10)

Опубликована: Июнь 29, 2024

Abstract Objectives Cortisol is an important metabolic hormone that regulates multiple physiologic systems. metabolism sensitive to early life environments, including experienced prenatally. Limited research has evaluated factors predict variation in maternal and offspring toddler hair cortisol, which since cortisol represents different dynamics of hypothalamic pituitary adrenal (HPA)‐axis function than more common salivary or serum measures. Methods To address this gap, we longitudinally whether depression measured pregnancy 1 month postnatal was associated with levels approximately 15 months after birth ( n = 46 mothers, 40 toddlers; mean 15.6 postnatal, SD 2.9 months). Results Mean symptoms were highest during the prenatal period. Prenatal, but not B 0.095, p .01). Maternal at either time point. Conclusions These findings indicate a year depression, consistent previous suggesting long‐term stress physiology may be influenced by conditions utero. highlight potential for cortisol—a minimally invasive easy‐to‐collect measure— index HPA‐axis dynamics.

Язык: Английский

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From placenta to the foetus: a systematic review of in vitro models of stress- and inflammation-induced depression in pregnancy

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Abstract Background Depression in pregnancy can increase vulnerability for psychiatric disorders the offspring, likely via transfer of heightened maternal cortisol and cytokines to in-utero environment. However, precise cellular molecular mechanisms, are largely unclear. Animal studies represent this complex pathophysiology at a systemic level but expensive ethically challenging. While simpler, vitro models offer high-throughput opportunities. Therefore, systematic review integrates findings relevant depression pregnancy, generate novel hypotheses targets intervention. Methods The analysis covered investigating glucocorticoid or cytokine challenges on placental foetal neural progenitor cells (NPCs), with without co-treatment sex hormones. Results Of 50 included studies, 11 used 39 NPCs; surprisingly, only one combination oestrogen cortisol, no study combined NPCs. In cells, decreased nutrient transporter expression steroidogenic enzyme activity, increased production. NPCs exhibited decreases proliferation differentiation, specific pathways, namely, inhibition hedgehog signalling activation kynurenine pathway. these also highlighted epigenetic priming stress inflammatory pathways. Conclusions Overall, results suggest that inflammation not detrimentally impact regulation nutrients hormones foetus, activate downstream pathways through placenta, ultimately eliciting adverse effects neurogenesis. Future research should investigate how regulate aim developing targeted therapeutic approaches pregnancy.

Язык: Английский

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Associations of gestational anxiety and depression with neonatal hair steroid levels

Psychoneuroendocrinology, Год журнала: 2024, Номер 172, С. 107260 - 107260

Опубликована: Дек. 19, 2024

Язык: Английский

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