Dengue-mediated changes in the vectorial capacity of Aedes aegypti (Diptera: Culicidae): manipulation of transmission or infection by-product? DOI Creative Commons

Ioana Mateescu,

Sébastian Lequime

Journal of Medical Entomology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

Abstract An arthropod’s vectorial capacity summarizes its disease transmission potential. Life-history traits, such as fecundity or survival, and behavioral locomotor activity, host-seeking feeding behavior, are important components of capacity. Studies have shown that mosquito-borne pathogens may alter traits their mosquito vectors, thus directly impacting epidemic Here, we compile discuss the evidence supporting dengue-mediated changes in yellow fever Aedes aegypti (L.), primary vector, evaluate whether observed effects represent an evolved trait manipulation with epidemiological implications. Dengue infection appears to manipulate essential facilitate vector–host contact, host-seeking, but underlying mechanisms still not understood. Conversely, life-history relevant vector population dynamics, oviposition, fecundity, appear be negatively impacted by dengue virus. Overall, any detrimental on a negligible cost derived from virulence has manipulating Ae. behavior performance. However, methodological disparities among studies render comparisons difficult limit ability reach well-supported conclusions. This highlights need for more standardized methods research into virus-mediated traits. Eventually, argue outlined here must considered when assessing impact other arbovirus–vector–host interactions.

Язык: Английский

Dengue Virus Serotype 1 Effects on Mosquito Survival Differ among Geographically Distinct Aedes aegypti Populations DOI Creative Commons
Milan S. G. Keirsebelik, Mariana Rocha David, Márcio G. Pavan

и другие.

Insects, Год журнала: 2024, Номер 15(6), С. 393 - 393

Опубликована: Май 28, 2024

The mosquito Aedes aegypti is distributed worldwide and recognized as the primary vector for dengue in numerous countries. To investigate whether fitness cost of a single DENV-1 isolate varies among populations, we selected four Ae. populations from distinct localities: Australia (AUS), Brazil (BRA), Pakistan (PAK), Peru (PER). Utilizing simple methodologies, concurrently assessed survival rates fecundity. Overall, infection led to significant decrease rates, with exception PER population. Furthermore, infected PAK, population lowest rate those tested, exhibited noteworthy reduction egg laying. These findings collectively suggest that local mosquito-virus adaptations may influence transmission endemic settings.

Язык: Английский

Процитировано

2
Tripartite interactions between viruses, parasites, and mosquitoes DOI Creative Commons
Michelle Schinkel, Teun Bousema, Ronald P. van Rij

и другие.

Current Opinion in Insect Science, Год журнала: 2024, Номер 64, С. 101222 - 101222

Опубликована: Июнь 20, 2024

Mosquito-borne diseases have a major impact on global human health. Biological agents that colonize the mosquito vector are increasingly explored as an intervention strategy to prevent vector-borne disease transmission. For instance, release of mosquitoes carrying endosymbiotic bacterium Wolbachia effectively reduced dengue virus incidence and disease. Insect-specific viruses likewise considered biocontrol against diseases. While most studies focused insect-specific arthropod-borne viruses, we here consider whether mosquito-specific may affect transmission malaria causing Plasmodium parasite by Anopheles mosquitoes. Although there is no direct experimental evidence addressing this question, found viral infections in dipteran insects activate some immune pathways antiparasitic Anopheles. These findings suggest indirect virus-parasite interactions could occur modulate Tripartite between parasites, thus merit further investigation.

Язык: Английский

Процитировано

1
Aedes albopictusis not an arbovirus aficionado – Impacts of sylvatic flavivirus infection in vectors and hosts on mosquito engorgement on non-human primates DOI Creative Commons
Hélène Cecilia, Benjamin M. Althouse, Sasha R. Azar

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 21, 2024

Abstract The contact structure between vertebrate hosts and arthropod vectors plays a key role in the spread of arthropod-borne viruses (arboviruses); thus, it is important to determine whether arbovirus infection either host or vector alters feeding behavior. Here we leveraged study replication dynamics two arboviruses isolated from their ancestral cycles paleotropical forests, sylvatic dengue-2 (DENV-2) Zika (ZIKV), one non-human primate (NHP) species paleotropics (cynomolgus macaques, Macaca fascicularis ) neotropics (squirrel monkeys, Saimiri boliviensis test effect both with each virus on completion blood (engorgement) mosquito Aedes albopictus . Although mosquitoes were starved given no choice hosts, engorgement rates varied dramatically, 0% 100%. While neither nor systematically affected engorgement, NHP body temperature at time did. We also interrogated repeated bites cytokine expression found that epidermal growth factor (EGF) macrophage migration inhibitory (MIF) concentrations dynamically associated exposure bites. This highlights importance incorporating individual-level heterogeneity biting transmission models.

Язык: Английский

Процитировано

0
A Laboratory-Adapted and a Clinical Isolate of Dengue Virus Serotype 4 Differently Impact Aedes aegypti Life-History Traits Relevant to Vectorial Capacity DOI Creative Commons

Mariana Maraschin,

Diego Novak,

Valdorion José Klein

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 7, 2024

Dengue virus cases are on the rise globally, and strategies to reduce new infections by controlling its primary vector, mosquito Aedes aegypti, represent a promising biotechnological approach. However, interaction between serotypes genotypes with aegypti is poorly characterized at molecular level, as well in terms of life-history traits related vector capacity disease tolerance. Here, we infected two philogenetically distant strains serotype 4 genotype II: laboratory-adapted strain, DENV4 - TVP/360, recent clinical strain isolated from southern Brazil, LRV 13/422. These strains, which exhibit 26 amino acid differences their sequences, have been shown produce distinct immune phenotypes vertebrate cells. assessed various including mortality, fecundity, fertility, induced flight capacity, competence-related parameters such infection intensity prevalence, following exposure different viral concentrations. We found that each differentially affected traits. While neither significantly reduced lifespan, prevalence was influenced initial dose TVP/360. This also enhanced induced-flight early (24 hours post-infection DPI) late (21 time points. On other hand, isolate, 13/422, specifically fertility. A better understanding how arbovirus influence connected spread will be critical public health efforts mitigate outbreaks focused vector.

Язык: Английский

Процитировано

0
À la carte: how mosquitoes choose their blood meals DOI
Sara Lynn Blanken, Wendy Prudhomme O’Meara, Felix J.H. Hol

и другие.

Trends in Parasitology, Год журнала: 2024, Номер 40(7), С. 591 - 603

Опубликована: Июнь 12, 2024

Язык: Английский

Процитировано

0
Aedes albopictus is not an arbovirus aficionado when feeding on cynomolgus macaques or squirrel monkeys DOI Creative Commons
Hélène Cecilia, Benjamin M. Althouse, Sasha R. Azar

и другие.

iScience, Год журнала: 2024, Номер 27(11), С. 111198 - 111198

Опубликована: Окт. 19, 2024

Язык: Английский

Процитировано

0
Dengue-mediated changes in the vectorial capacity of Aedes aegypti (Diptera: Culicidae): manipulation of transmission or infection by-product? DOI Creative Commons

Ioana Mateescu,

Sébastian Lequime

Journal of Medical Entomology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

Abstract An arthropod’s vectorial capacity summarizes its disease transmission potential. Life-history traits, such as fecundity or survival, and behavioral locomotor activity, host-seeking feeding behavior, are important components of capacity. Studies have shown that mosquito-borne pathogens may alter traits their mosquito vectors, thus directly impacting epidemic Here, we compile discuss the evidence supporting dengue-mediated changes in yellow fever Aedes aegypti (L.), primary vector, evaluate whether observed effects represent an evolved trait manipulation with epidemiological implications. Dengue infection appears to manipulate essential facilitate vector–host contact, host-seeking, but underlying mechanisms still not understood. Conversely, life-history relevant vector population dynamics, oviposition, fecundity, appear be negatively impacted by dengue virus. Overall, any detrimental on a negligible cost derived from virulence has manipulating Ae. behavior performance. However, methodological disparities among studies render comparisons difficult limit ability reach well-supported conclusions. This highlights need for more standardized methods research into virus-mediated traits. Eventually, argue outlined here must considered when assessing impact other arbovirus–vector–host interactions.

Язык: Английский

Процитировано

0