New guidelines and recommendations to advance treatment planning in proton therapy

Physics and Imaging in Radiation Oncology, Год журнала: 2025, Номер 33, С. 100695 - 100695

Опубликована: Янв. 1, 2025

Язык: Английский

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Envisioning an Italian head and neck proton therapy model-based selection: challenge and opportunity

International Journal of Particle Therapy, Год журнала: 2025, Номер 16, С. 100745 - 100745

Опубликована: Март 20, 2025

Язык: Английский

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Consistency in contouring of organs at risk by artificial intelligence vs oncologists in head and neck cancer patients

Acta Oncologica, Год журнала: 2023, Номер 62(11), С. 1418 - 1425

Опубликована: Сен. 13, 2023

AbstractBackground In the Danish Head and Neck Cancer Group (DAHANCA) 35 trial, patients are selected for proton treatment based on simulated reductions of Normal Tissue Complication Probability (NTCP) compared to photon at referring departments. After inclusion in immobilization, scanning, contouring planning repeated national centre. The new contours could result reduced expected NTCP gain plan, resulting a loss validity selection process. present study evaluates if contour consistency can be improved by having access AI (Artificial Intelligence) contours.Materials Methods 63 DAHANCA pilot trial had CT from local centre one A nationally validated convolutional neural network, nnU-Net, was used OARs both scans each patient. Using deformable image registration, oncologist were transferred comparison. Consistency calculated with Dice Similarity Coefficient (DSC) Mean Surface Distance (MSD), comparing oncologist, respectively. Two models applied calculate xerostomia dysphagia.Results showed significantly better than oncologists. median interquartile range DSC 0.85 [0.78 − 0.90] 0.68 [0.51 0.80] contours, MSD 0.9 mm [0.7 1.1] 1.9 [1.5 2.6] There no significant difference ΔNTCP.Conclusions that OAR made algorithm more consistent those No impact ΔNTCP calculations discerned.Keywords: AIcontouringorgans riskhead neck cancerproton Disclosure statementNo potential conflict interest reported author(s).Data availability statementThe data this part clinical not available.Additional informationFundingSupported Novo Nordisk Foundation (NNF18OC0034612), DCCC Radiotherapy - National Research Center Radiotherapy, Society (grant no. R191-A11526), Comprehensive Center, University Southern Denmark Faculty Health Sciences Scholarship, Odense Hospital.

Язык: Английский

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Proton- compared to X-irradiation leads to more acinar atrophy and greater hyposalivation accompanied by a differential cytokine response

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 27, 2024

Proton therapy gives less dose to healthy tissue compared conventional X-ray therapy, but systematic comparisons of normal responses are lacking. The aim this study was investigate late in the salivary glands following proton- or X-irradiation head and neck mice. Moreover, we aimed at investigating molecular by monitoring cytokine levels serum saliva. Female C57BL/6J mice underwent local fractionated irradiation with protons X-rays maximally tolerated acute level. Saliva were collected before different time points after assess gland function expression. To major glands, histological analyses performed on tissues day 105 onset irradiation. volume proton significantly lower than for controls remained reduced all Protons caused saliva production fewer acinar cells submandibular 105. induced a stronger inflammatory response protons. This work supports previous preclinical findings indicate that relative biological effectiveness might be higher commonly used value 1.1.

Язык: Английский

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Proton beam radiotherapy head and neck cancer study design and endpoints

Radiotherapy and Oncology, Год журнала: 2024, Номер 195, С. 110234 - 110234

Опубликована: Март 16, 2024

Язык: Английский

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Pharyngeal Constrictor Muscle Sparing in Head and Neck Radiotherapy

Clinical Oncology, Год журнала: 2024, Номер 36(5), С. e118 - e118

Опубликована: Фев. 15, 2024

Язык: Английский

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Response to the letter by Boon and colleagues

Radiotherapy and Oncology, Год журнала: 2024, Номер 195, С. 110233 - 110233

Опубликована: Март 25, 2024

Язык: Английский

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Acute Toxicities in Proton Therapy for Head and Neck Cancer – a Matched Analysis of the Dahanca 35 Feasibility Study

Опубликована: Янв. 1, 2024

Background and purpose: As preparation for a national randomized study comparing proton radiotherapy to photon radiotherapy, DAHANCA 35, we performed non-randomized pilot investigate patient selection, logistics, planning, treatment delivery. With the present study, as comprehensive safety analysis, want compare toxicity during up two months after therapy historically matched group of patients treated with radiotherapy. Materials methods: 62 protons were 124 who received outside protocol. Available data retrieved from database. Patients on centre, concurrent chemotherapy, tumour site, stage, p16 status oropharynx cancers. Results: Baseline characteristics between groups well balanced, except type drug used concurrently; more Carboplatin (21.2% vs 5.8%, p=0.01). Proton was associated significantly less weight loss at end treatment, mean 3% 5% photons (p<0.001). There grade 3 skin reactions mucositis compared Risk Ratio (RR) 1.9 (95% CI: 1.01-3.5, p=0.04) RR 1.5 1.3-1.7, p<0.001), respectively. All differences resolved follow treatment. no significant opioid use, use feeding tubes, or hospitalization observation period. Conclusion: resulted in excess objective dermatitis, which transient did not seem negatively influence compliance intensity. Selection bias likely, are currently including controlled trial.

Язык: Английский

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Physician barriers and dilemmas in the execution of clinical trials impacting decision-making in the DAHANCA 35 proton therapy trial for head and neck cancer

Technical Innovations & Patient Support in Radiation Oncology, Год журнала: 2024, Номер 31, С. 100259 - 100259

Опубликована: Июнь 28, 2024

Язык: Английский

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Acute toxicities in proton therapy for head and neck cancer – A matched analysis of the DAHANCA 35 feasibility study

Clinical and Translational Radiation Oncology, Год журнала: 2024, Номер 48, С. 100835 - 100835

Опубликована: Июль 31, 2024

Язык: Английский

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