Postoperative Outcomes of One-Step Implant-Based Breast and Ovarian Surgery in High-Penetrance Gene Mutation: A Single-Center Experience
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(6), С. 1784 - 1784
Опубликована: Март 7, 2025
Background/Objectives:
This
study
was
designed
to
evaluate
skin-sparing
mastectomy
with
implant
reconstruction
complication
rates
in
patients
operated
on
due
high
penetrant
gene
profile.
All
went
and
risk-reducing
salpingo-oophorectomy.
The
effect
of
radiotherapy
chemotherapy
wound
healing
is
a
frequently
discussed
topic
the
literature.
However,
studies
these
undergoing
implant-based
are
rare.
In
our
clinic,
two
surgeries
performed
under
same
anesthesia
it
aimed
investigate
this
situation
complications
rare
patient
group.
retrospective
study,
we
report
clinical
experience
regarding
factors
among
Methods:
Between
June
2022
2024,
61
were
grouped
according
demographic
data.
Post-operative
defined
as
any
following:
major
which
active
bleeding
or
dehiscence;
minor
hematoma,
seroma,
surgical-site
infection,
<20%
skin
nipple
necrosis,
reoperation
dehiscence
other
complication.
Patients
compared
terms
whether
they
received
previous
(RT),
neoadjuvant
(CT),
underwent
skin-reducing
mammoplasty.
Results:
receiving
chemotherapy,
preoperative
RT,
complications.
While
CT
RT
only
increased
risk
found
that
had
no
significant
rates.
Conclusions:
Skin-sparing
salphingo-oophorectomy
comprehensive
operation
method
Complication
control
can
be
achieved
by
performing
single
period,
using
spy
immunofluorescence
device
for
vascularization
control,
all
experienced
team.
Язык: Английский
Swedish Genome-Wide Haplotype Association Analysis Suggests Breast Cancer Loci with Varying Risk-Modifying Effects
Genes,
Год журнала:
2024,
Номер
15(12), С. 1616 - 1616
Опубликована: Дек. 17, 2024
Background:
To
find
support
for
risk-modifying
genes
in
breast
cancer,
a
haplotype
GWAS
sporadic
cancer
cases
was
undertaken.
The
results
were
compared
with
the
from
previous
analyses
familial
and
all
same
Swedish
cohort.
Methods:
In
total,
2550
women
invasive
5021
healthy
controls
included
sliding-window
using
PLINK
1.07.
Results:
analysis
of
confirmed
loci
on
chromosomes
10q26.13,
11q13.3,
16q12.1
suggested
one
novel
locus
chromosome
12p11.21
(OR
=
1.42
p
4.55
×
10−8).
A
comparison
between
these
Conclusions:
Haplotype
supported
known
risk
another
locus.
identified
to
act
as
modifiers
cancer.
other
higher
odds
ratios
than
single-variant
analysis.
Further
studies
are
needed
out
how
best
include
findings
prevention.
Язык: Английский