International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139137 - 139137
Опубликована: Дек. 1, 2024
Язык: Английский
Macromolecular Materials and Engineering, Год журнала: 2025, Номер unknown
Опубликована: Фев. 17, 2025
Abstract Cartilage defects are common joint disorders that, if left untreated, may progress to severe degenerative conditions. Inflammatory response plays a critical role in the pathogenesis of cartilage damage. Hydrogels incorporating diacerein, an anti‐inflammatory drug used clinical settings, can mitigate inflammation that impairs repair. It is hypothesized direct injection hydrogel scaffold combining diacerein and polydopamine into defect sites enhance localized treatment, reduce surgical risks, expedite recovery. Therefore, this study, infused with developed investigate its efficacy for restoration. By crosslinking poly(ethylene glycol) diacrylate, four‐arm polyethylene glycol‐functionalized hyaluronic acid, polydopamine, injectable superior properties achieved. In vitro evaluations confirm mechanical strength biocompatibility hydrogel, vivo studies demonstrate effectiveness repair activity rat model. These findings indicate hydrogels promising materials addressing advancing tissue engineering biological implantation strategies.
Язык: Английский
Процитировано
0
Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Cartilage tissue engineering based on the combination of biomaterials, adult or stem cells and bioactive factors is a challenging approach for regenerative medicine with aim achieving formation functional neotissue stable in long term. Various 3D scaffolds have been developed to mimic extracellular matrix environment promote cartilage repair. In addition, extensively employed induce maintain phenotype. However, spatiotemporal control factor release remains critical maximizing potential multipotent cells, such as mesenchymal stromal (MSCs), efficient chondrogenesis sustained homeostasis, which are essential repair hyaline cartilage. Despite advances, effective delivery limited by challenges insufficient retention at site injury loss therapeutic efficacy due uncontrolled drug release. These limitations prompted research biomolecule-scaffold interactions develop advanced systems that provide controlled bioavailability biological factors, thereby improving outcomes. This review focuses specifically biomaterials (natural, hybrid synthetic) biomolecules (molecules, proteins, nucleic acids) interest engineering. Herein, we detail approaches their release, chemical nature structure, through steric, non-covalent and/or covalent interactions, view application
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 529 - 529
Опубликована: Апрель 17, 2025
Antimicrobial delivery systems have undergone extensive development, yet conventional carriers still exhibit limitations such as low loading capacity, inadequate controlled release mechanisms, and cytotoxicity. Recent studies increasingly demonstrated the potential of Hydrogel Microspheres (HMSs) for antimicrobial delivery. These microspheres small dimensions, high drug-loading ability to achieve deep-targeted delivery, complemented by adjustable physicochemical properties biocompatibility that create favorable conditions transportation. This review systematically examines HMS preparation strategies, characteristic properties, transported antimicrobials, therapeutic applications. Particular emphasis is placed on critical parameters governing performance, especially those influencing drug dynamics. We conclude addressing current challenges proposing actionable strategies material optimization clinical translation. work aims advance HMS-based more effective infection control.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139137 - 139137
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
2