Cardiac Rehabilitation — Challenges, Advances, and the Road Ahead

New England Journal of Medicine, Год журнала: 2024, Номер 390(9), С. 830 - 841

Опубликована: Фев. 28, 2024

Cardiac rehabilitation provides evidence-based, secondary prevention after a cardiovascular event. This review addresses the benefits of cardiac programs and current barriers to participation.

Язык: Английский

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When Direct Oral Anticoagulants Should Not Be Standard Treatment

Journal of the American College of Cardiology, Год журнала: 2024, Номер 83(3), С. 444 - 465

Опубликована: Янв. 1, 2024

Язык: Английский

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A Clinical Guide for Assessment and Prescription of Exercise and Physical Activity in Cardiac Rehabilitation. A CSANZ Position Statement

Heart Lung and Circulation, Год журнала: 2023, Номер 32(9), С. 1035 - 1048

Опубликована: Июль 27, 2023

Patients with cardiovascular disease benefit from cardiac rehabilitation, which includes structured exercise and physical activity as core components. This position statement provides pragmatic, evidence-based guidance for the assessment prescription of rehabilitation clinicians, recognising latest international guidelines, scientific evidence increasing use technology virtual delivery methods. The patient-centred aerobic exercise, resistance have been addressed, including progression safety considerations.

Язык: Английский

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Rationale and Design of SCOT-HEART 2 Trial

JACC. Cardiovascular imaging, Год журнала: 2024, Номер 17(9), С. 1101 - 1112

Опубликована: Июль 10, 2024

Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk coronary remains a public health priority. At present, focus cardiovascular prevention relies heavily on probabilistic scoring despite no randomized controlled trials demonstrating their efficacy. The concept using imaging guide preventative therapy is not new, but has previously focused indirect measures such as carotid intima-media thickening or calcification. In recent trials, found have computed tomography (CT) angiography were more likely started and had lower rates cardiac events. This led design SCOT-HEART 2 (Scottish Computed Tomography Heart 2) trial, which aims determine whether screening with use CT clinically effective than primary therapies reduce myocardial infarction.

Язык: Английский

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Inflammatory markers after supplementation with marine n-3 or plant n-6 PUFAs: a randomized double-blind crossover study

Journal of Lipid Research, Год журнала: 2025, Номер unknown, С. 100770 - 100770

Опубликована: Март 1, 2025

Highlights•lower circulating inflammatory markers (TNF, RANTES) after n-3 or n-6 PUFA intake•reduction intake also in MIP-1alpha, MIP-1beta and MCP-1•increased gene expression adipose tissue by but not intake•increased MCP-1 upon treating cultured human adipocytes with PUFA•tissue-specific effects of PUFA, a net systemic anti-inflammatory effectAbstractn-3 (e.g., EPA/DHA) LA) fatty acids are suggested to have opposite on inflammation, results inconsistent direct comparisons lacking. In double-blind, randomized crossover study, females (n=16) males (n=23) aged 30–70 years abdominal obesity were supplemented 3–4g/d EPA/DHA (fish oil) 15–20g/d LA (safflower for 7 weeks, 9-week washout phase. Cytokines chemokines (multiplex assay), acute-phase proteins (MALDI-TOF mass spectrometry), endothelial function (vascular reaction index (VRI)), blood pressure, acid composition (RBCMs/serum/adipose tissue, GC-MS/MS) (microarrays, qPCR) measured. While significant differences between treatments relative change scores found systolic pressure (n-3 vs. n-6: −1.81% 2.61%, p=0.003), no difference any circulatory markers. However, compared baseline, was followed reductions TNF (−24.9%, p<0.001), RANTES (−12.1%, MIP-1β (−12.5%, p=0.014), lowered (−18.8%, (−7.37%, p=0.027), (−7.81%, p=0.020), (−14.2%, p=0.010). Adipose showed treatment weight percent EPA 50.2%* −1.38%, p<0.001, *: within-treatment score), DHA (16.0%* -3.67%, (−0.033 4.91%*, p<0.001). transcriptomics revealed overall down-regulation genes related processes up-regulation n-6, partly correlating changes These data point tissue-specific pro-inflammatory high intake, effect as n-3.

Язык: Английский

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Application of Machine Learning Techniques to Assess Alpha-Fetoprotein at Diagnosis of Hepatocellular Carcinoma

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 1996 - 1996

Опубликована: Фев. 7, 2024

Hepatocellular carcinoma (HCC) is the most common primary liver tumor and associated with high mortality rates. Approximately 80% of cases occur in cirrhotic livers, posing a significant challenge for appropriate therapeutic management. Adequate screening programs high-risk groups are essential early-stage detection. The extent extrahepatic spread hepatic functional reserve recognized as two influential prognostic factors. In this retrospective multicenter study, we utilized machine learning (ML) methods to analyze predictors at time diagnosis total 208 patients. eXtreme gradient boosting (XGB) method achieved highest values identifying key factors HCC diagnosis. etiology was found be variable strongly poorer prognosis. widely used Barcelona Clinic Liver Cancer (BCLC) classification our setting demonstrated superiority over TNM classification. Although alpha-fetoprotein (AFP) remains commonly biological marker, elevated levels did not correlate reduced survival. Our findings suggest need explore new biomarkers individualized management these

Язык: Английский

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The burden of cardiovascular disease and related risk factors in Greece: the ATTICA epidemiological study (2002–2022)

Hellenic Journal of Cardiology, Год журнала: 2024, Номер unknown

Опубликована: Май 1, 2024

The aim of this study was to present the burden cardiovascular disease (CVD) and its related risk factors based on a 20-year observation period (2002-2022).

Язык: Английский

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Cardiac rehabilitation and acute aortic dissection: understanding and addressing the evidence GAP a systematic review

Current Problems in Cardiology, Год журнала: 2024, Номер 49(3), С. 102348 - 102348

Опубликована: Янв. 21, 2024

Despite guideline recommendations, strategies for implementing cardiac rehabilitation (CR) in patients with acute aortic dissection (AAD) are not well established little evidence to risk stratify prudent and effective guidelines the many required variables. We conducted a systematic review of studies (2004-2023) reporting CR following type A (TA) B (TB) AAD. Our is limited open surgical repair TA medical treatment TB. total 5 were included (4 TA-AAD 1 TB-AAD) qualitative analysis. In general, observational data 311 who had an overall favorable effect AAD consisting modestly improved exercise capacity work load during cycle cardiopulmonary test (TB-AAD), quality life (QoL). No adverse events reported symptom pre-CR treadmill or VO2 max CR. Given potential this high population without adequate important variables such as safe time from post-op CR, intensity training, duration frequency sessions followup it moderate sized designed trial patients' surgery medically treated TB-AAD standardized based therapy physical discharge randomized versus usual care. PROSPERO registry ID: CRD42023392896.

Язык: Английский

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Eficiencia de las combinaciones a dosis fija de estatina y ezetimiba en el tratamiento de la hipercolesterolemia

Clínica e Investigación en Arteriosclerosis, Год журнала: 2025, Номер unknown, С. 500753 - 500753

Опубликована: Янв. 1, 2025

Язык: Английский

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Sudoscan® reclassifies cardiovascular risk in patients with type 2 diabetes mellitus according to the ESC 2023

Journal of Diabetes & Metabolic Disorders, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 17, 2025

Язык: Английский

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