Polycyclic aromatic compounds,
Год журнала:
2023,
Номер
44(3), С. 1697 - 1721
Опубликована: Май 2, 2023
One
of
the
important
classes
aza-polycyclic
compounds
is
Phenazine
systems
which
are
naturally
present
and
synthetically
derived.
More
than
6000
phenazine
recognized;
among
them,
pyran
chromene
fused
Benzo[α]phenazines
have
gained
special
attention
due
to
their
fascinating
biological
properties.
In
this
regard,
synthesizing
these
phenazinle
derivatives
by
multicomponent
reactions
has
much
advantages
associated
with
process.
Hence
seeing
contribution
benzo
phenazines
pharmaceutical
field,
review
highlights
synthesis
different
catalytic
conditions
involving
use
nontoxic
catalysts
solvents
in
a
system.
This
evaluates
studies
reported
since
2012
on
green
phenazines.
RSC Advances,
Год журнала:
2023,
Номер
13(40), С. 28030 - 28041
Опубликована: Янв. 1, 2023
Traditional
chemical
synthesis,
which
involves
the
use
of
dangerous
protocols,
hazardous
solvents,
and
toxic
products
catalysts,
is
considered
environmentally
inappropriate
harmful
to
human
health.
Bearing
in
mind
its
numerous
drawbacks,
it
has
become
crucial
substitute
conventional
chemistry
with
green
safer,
more
ecofriendly
effective
terms
time
selectivity.
Elaborating
synthetic
protocols
producing
interesting
new
compounds
using
both
microwave
heating
heterogeneous
non-toxic
catalysts
acknowledged
as
a
approach
that
avoids
many
classical
chemistry-related
problems.
In
current
study,
β-enaminones
were
used
precursors
synthesis
modified
4-hydroxy-2-quinolone
analogues.
The
was
monitored
benign
way
under
irradiation
catalyzed
by
bismuth
chloride
III
an
amount
20
mol%.
This
method
privileged
non-corrosive,
non-toxic,
low-cost
available
Lewis
acid
catalyst
made
respectful
demands
chemistry.
synthesized
obtained
moderate
good
yields
(51-71%)
characterized
1H,
13C
NMR,
IR
spectroscopy
well
elemental
analysis.
Compound
5i
subjected
complete
structural
elucidation
X-ray
diffraction
method,
results
show
obtention
enolic
tautomeric
form.
Current Microwave Chemistry,
Год журнала:
2023,
Номер
10(2), С. 122 - 134
Опубликована: Сен. 1, 2023
Abstract:
One
of
the
most
efficient
non-conventional
heating
methods
is
microwave
irradiation.
In
organic
synthesis,
irradiation
has
become
a
popular
technique
as
it
enhances
product
yields
and
purities,
reduces
reaction
time
from
hours
to
minutes,
decreases
unwanted
side
reactions.
Microwave-assisted
synthesis
utilizes
dielectric
volumetric
an
alternative
activation
method,
which
results
in
rapid
more
selective
transformations
because
uniform
heat
distribution.
Heterocyclic
compounds
have
profound
role
drug
discov-ery
development
process
along
with
their
applications
agrochemicals,
fungicides,
herbi-cides,
etc.,
making
them
prevalent
form
biologically
relevant
molecules.
Hence,
enor-mous
efforts
been
made
flourish
green
routes
for
high-yielding
under
mi-crowave
sustainable
tool.
Among
different
clinical
applications,
heterocyclic
received
considerable
attention
anti-cancer
agents.
moieties
always
core
parts
drugs,
including
market-selling
i.e.,
5-fluorouracil,
doxorubicin,
methotrexate,
daunorubicin,
natural
alkaloids,
such
vinblastine
vincristine.
this
review,
we
focus
on
developments
microwave-assisted
heterocycles
activities
particular
heterocycles.
Journal of Heterocyclic Chemistry,
Год журнала:
2024,
Номер
61(6), С. 1009 - 1014
Опубликована: Апрель 4, 2024
Abstract
An
innovative
green
procedure
has
been
devised
to
prepare
derivatives
of
1,4‐dihydropyridine
(1,4‐DHP).
This
method
works
with
a
catalyst
process
using
ethanol
as
solvent
under
microwave
irradiation
conditions,
enabling
swift
reactions
(<30
min)
impressive
yields
(90%–96%).
It
contributes
an
environmentally
friendly
and
easily
executable
by
the
energy
efficiency
method.
Within
30
min,
this
underscores
ecologically
conscious
practices
offers
simple
purification,
streamlining
omitting
column
chromatography.
highlights
efficacy
eco‐friendly
nature
synthesizing
1,4‐DHPs.
combines
four
component
reactions,
utilizing
EtOH
triethylamine
catalyst.
Furthermore,
product
was
characterized
diverse
spectroscopic
analysis.
Cleaner Engineering and Technology,
Год журнала:
2024,
Номер
21, С. 100762 - 100762
Опубликована: Май 31, 2024
The
synthesis
of
novel
benzo-[7]-annulene-1,3-dicarbonitrile
analogues
has
been
accomplished
using
an
environmentally
friendly
and
green
protocol.
This
mortar
pestle
grinding
method
that
is
both
ethically
responsible
commercially
practical.
By
producing
the
necessary
with
good
results
(89%-97%)
in
a
short
reaction
time
(≤
30
minutes),
this
approach
successfully
indicates
even
aldehydes
severe
steric
hindrance
play
active
part
process.
faster
work-up
processes,
reduction
operating
difficulties,
increased
yields
are
notable
among
its
advantages
over
earlier
systems.
strategy
uses
method,
which
well
known
for
following
guidelines
economically
sensible
friendly.
It
important
to
note
offers
considerable
advancement
approaches
were
characterized
by
drawn-out
procedures,
operational
complexity,
low
yields.
