Multi-Auto-Tandem Reaction to Access Site-Specific Functionalized Tricyclic Furo[3,2-c]coumarins and Naphtho[2,3-b]furan-4,9-diones DOI
Xiang Liu, Hexiang Wang, Dongxin Lin

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

A three-component multi-auto-tandem reaction for the construction of site-specific tricyclic furo[3,2-c]coumarins via formation C-C, C-O, and C-S bonds in one step from 4-hydroxycoumarins/4-hydroxy-2-pyrones, ynals, sodium sulfinates is reported. This cascade efficiently produces a variety rare C-2-functionalized moderate to good yields under straightforward conditions. Furthermore, this protocol can be extended coupling involving 2-hydroxy-1,4-naphthoquinone, sulfinates, yielding naphtho[2,3-b]furan-4,9-dione derivatives. Notably, carbonyl group α-position ynals act as C-2 synthons specific reaction, enabling two aforementioned types multicomponent transformations.

Язык: Английский

Multi-Auto-Tandem Reaction to Access Site-Specific Functionalized Tricyclic Furo[3,2-c]coumarins and Naphtho[2,3-b]furan-4,9-diones DOI
Xiang Liu, Hexiang Wang, Dongxin Lin

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

A three-component multi-auto-tandem reaction for the construction of site-specific tricyclic furo[3,2-c]coumarins via formation C-C, C-O, and C-S bonds in one step from 4-hydroxycoumarins/4-hydroxy-2-pyrones, ynals, sodium sulfinates is reported. This cascade efficiently produces a variety rare C-2-functionalized moderate to good yields under straightforward conditions. Furthermore, this protocol can be extended coupling involving 2-hydroxy-1,4-naphthoquinone, sulfinates, yielding naphtho[2,3-b]furan-4,9-dione derivatives. Notably, carbonyl group α-position ynals act as C-2 synthons specific reaction, enabling two aforementioned types multicomponent transformations.

Язык: Английский

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