Rational design, synthesis and anticancer screening of 1,2,4-oxadiazole incorporated thieno[2,3-d]thiazole-isoxazole-pyridine derivatives DOI Creative Commons

Rambabu Vasamsetti,

Naresh Babu Gatchakayala,

Pawan Kumar

и другие.

Results in Chemistry, Год журнала: 2024, Номер unknown, С. 101823 - 101823

Опубликована: Сен. 1, 2024

Язык: Английский

Anticancer potential of coumarins from the Ferulago genus DOI Creative Commons

Mansour Mofasseri,

Elham Eini,

Saber Mofasseri

и другие.

Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102033 - 102033

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Nano‐Encapsulated Coumarin Derivative, CS‐QM2 Inhibits Neoplasm Growth: Experimented in Zebrafish Model DOI Open Access

S Madesh,

Raghul Murugan, A. C. SAU

и другие.

Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(4)

Опубликована: Март 27, 2025

Cancer remains a significant global health challenge with limited therapeutic success, prompting the need for innovative treatment strategies. This study investigates anticancer potential of nano-encapsulated metal derivatives (CS-QM2) using zebrafish model chemically induced cellular neoplasia. Characterization CS-QM2 nanoparticles revealed successful synthesis high entrapment efficiency and enhanced drug release under acidic conditions. Zebrafish embryos exposed to 7,12-Dimethylbenz[a]anthracene (DMBA) exhibited malformations, macrophage accumulation, abnormal tissue growth, which were markedly reduced by treatment. significantly increases intracellular ROS, resulting in higher LPO induces apoptosis neoplasm tissues. Furthermore, alters tumor microenvironment, reducing accumulation decreasing neutral lipid droplets, disrupting TAM metabolic support limiting their protumorigenic activities. Biochemical assays demonstrated restored activities antioxidant enzymes SOD, CAT, GSH. Gene expression analysis showed upregulation suppressor genes (cas3, p53) downregulation inflammatory (cox-2, nf-kb). Histological assessment SEM confirmed occurrence abnormalities. These findings suggest that effectively inhibit growth modulate microenvironment through oxidative stress induction gene regulation.

Язык: Английский

Процитировано

0
Novel Benzohydrazide Derivative as a Potential Anticarcinogenic Agent for Breast Cancer: Synthesis, Crystal Structure, In Vitro and In Silico Assessments DOI
Tolga Göktürk, Cansu Topkaya, Turan Demircan

и другие.

Journal of Molecular Structure, Год журнала: 2024, Номер 1323, С. 140673 - 140673

Опубликована: Ноя. 8, 2024

Язык: Английский

Процитировано

1
Rational design, synthesis and anticancer screening of 1,2,4-oxadiazole incorporated thieno[2,3-d]thiazole-isoxazole-pyridine derivatives DOI Creative Commons

Rambabu Vasamsetti,

Naresh Babu Gatchakayala,

Pawan Kumar

и другие.

Results in Chemistry, Год журнала: 2024, Номер unknown, С. 101823 - 101823

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

0