Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

Experimental & Molecular Medicine, Год журнала: 2021, Номер 53(2), С. 168 - 188

Опубликована: Фев. 1, 2021

Abstract Advanced glycation end products (AGEs) are potentially harmful and heterogeneous molecules derived from nonenzymatic glycation. The pathological implications of AGEs ascribed to their ability promote oxidative stress, inflammation, apoptosis. Recent studies in basic translational research have revealed the contributing roles development progression various aging-related conditions, such as diabetes, cardiovascular complications, gut microbiome-associated illnesses, liver or neurodegenerative diseases, cancer. Excessive chronic and/or acute binge consumption alcohol (ethanol), a widely consumed addictive substance, is known cause more than 200 including use disorder (addiction), alcoholic disease, brain damage. However, despite considerable amount this area, underlying molecular mechanisms by which abuse causes cellular toxicity organ damage remain be further characterized. In review, we first briefly describe properties AGEs: formation, accumulation, receptor interactions. We then focus on causative functions that impact diseases. also highlight biological connection AGE–alcohol–adduct formations alcohol-mediated tissue injury. Finally, potential opportunities for treatment AGE- alcohol-related adduct-associated disorders according mechanistic insights presented.

Язык: Английский

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Translational Approaches with Antioxidant Phytochemicals against Alcohol-Mediated Oxidative Stress, Gut Dysbiosis, Intestinal Barrier Dysfunction, and Fatty Liver Disease

Antioxidants, Год журнала: 2021, Номер 10(3), С. 384 - 384

Опубликована: Март 4, 2021

Emerging data demonstrate the important roles of altered gut microbiomes (dysbiosis) in many disease states peripheral tissues and central nervous system. Gut dysbiosis with decreased ratios Bacteroidetes/Firmicutes other changes are reported to be caused by various environmental factors, such as ethanol (e.g., alcohol drinking), Western-style high-fat diets, high fructose, etc. It is also genetic including polymorphisms epigenetic different individuals. dysbiosis, impaired intestinal barrier function, elevated serum endotoxin levels can observed human patients and/or experimental rodent models exposed these factors or certain states. However, leaky normalized through lifestyle alterations increased consumption healthy diets fruits vegetables containing kinds antioxidant phytochemicals. In this review, we describe mechanisms gut, endotoxemia, fatty liver a specific focus on alcohol-associated pathways. We mention translational approaches discussing benefits phytochemicals their metabolites against alcohol-mediated oxidative stress, dysfunction, disease.

Язык: Английский

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Musculus senhousei as a promising source of bioactive peptides protecting against alcohol-induced liver injury

Food and Chemical Toxicology, Год журнала: 2023, Номер 174, С. 113652 - 113652

Опубликована: Фев. 9, 2023

Язык: Английский

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Antrodin A from mycelium of Antrodia camphorata alleviates acute alcoholic liver injury and modulates intestinal flora dysbiosis in mice

Journal of Ethnopharmacology, Год журнала: 2020, Номер 254, С. 112681 - 112681

Опубликована: Фев. 19, 2020

Язык: Английский

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Propionate Ameliorates Alcohol-Induced Liver Injury in Mice via the Gut–Liver Axis: Focus on the Improvement of Intestinal Permeability

Journal of Agricultural and Food Chemistry, Год журнала: 2022, Номер 70(20), С. 6084 - 6096

Опубликована: Май 12, 2022

Alcohol-related liver disease (ALD) is a major cause of chronic worldwide with limited therapeutic options. Here, we first revealed the promising beneficial effect gut microbiota-derived propionate on alcoholic injury in mice. This was dependent modulation homeostasis gut-liver axis, especially improvement intestinal permeability. Dietary supplementation protected against ethanol-induced loss hepatic function and steatosis Meanwhile, treatment attenuated epithelial barrier dysfunction, restored expression mucus layer components, suppressed inflammation, altered microbiota dysbiosis, which inhibited hyperpermeability subsequently reduced lipopolysaccharide leakage ALD Furthermore, as consequence endotoxemia amelioration, inflammation-related TLR4-NF-κB pathway inhibited. Collectively, our results suggested that may be option for prevention ALD.

Язык: Английский

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The Role of Gut Bacteria and Fungi in Alcohol-Associated Liver Disease

Frontiers in Medicine, Год журнала: 2022, Номер 9

Опубликована: Март 3, 2022

Cirrhosis and liver cancer caused by alcohol-associated disease (ALD) are serious threats to people's health. In addition hepatic cell apoptosis inflammation oxidative stress during alcohol metabolism, intestinal microbiota disorders also involved in the onset development of ALD. Ethanol its' non-oxidative metabolites, together with dysbiosis-caused-inflammation, destroys barrier. Changes several microbial such as bile acids, short-chain fatty amino acid, closely associated gut dysbiosis The alcohol-caused can further influence barrier-related proteins, mucin2, acid-related receptors, aryl hydrocarbon receptor (AhR), these abnormal changes participate injury barrier steatosis. Gut-derived bacteria, fungi, their toxins, lipopolysaccharide (LPS) β-glucan translocate into through damaged promote progression fibrosis Thus, prevention alcohol-induced disruption permeability has a beneficial effect on Currently, multiple therapeutic treatments have been applied restore patients Fecal transplantation, probiotics, antibiotics, many other elements already shown ability restoring microbiota. Targeted approaches, using bacteriophages remove cytolytic Enterococcus faecalis , supplement Lactobacillus, Bifidobacterium or boulardii powerful options for

Язык: Английский

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ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis

Redox Biology, Год журнала: 2022, Номер 59, С. 102577 - 102577

Опубликована: Дек. 13, 2022

Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is the major enzyme responsible for metabolizing toxic acetaldehyde to acetate and acts as a protective or defensive protein against various disease states associated with alcohol use disorder (AUD), including alcohol-related liver (ARLD). We hypothesized that Aldh2-knockout (KO) mice are more susceptible binge alcohol-mediated injury than wild-type (WT) through increased oxidative stress, gut leakiness endotoxemia. Therefore, this study aimed investigate role of ALDH2 in alcohol-induced permeability, endotoxemia, acute inflammatory by exposing Aldh2-KO WT single oral dose 3.5, 4.0, 5.0 g/kg. Our findings showed first time deficiency increases their sensitivity nitrative enterocyte apoptosis, nitration tight junction (TJ) adherent (AJ) proteins, leading degradation. These resulted endotoxemia after exposure ethanol even at 3.5 g/kg, while no changes were observed corresponding mice. The elevated serum endotoxin (lipopolysaccharide, LPS) bacterial translocation contributed systemic inflammation, hepatocyte subsequently gut-liver axis. Treatment Daidzin, an inhibitor, exacerbated ethanol-induced cell permeability reduced TJ/AJ proteins T84 human colon cells. reversed Alda-1, activator. Furthermore, CRISPR/Cas9-mediated knockout cells damage paracellular permeability. All these demonstrate critical epithelial barrier dysfunction suggest gene mutation humans risk factor injury, could be important therapeutic target alcohol-associated tissue organ damage.

Язык: Английский

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Bioactive compounds and health benefits of pomegranate: An updated narrative review

Food Bioscience, Год журнала: 2023, Номер 53, С. 102629 - 102629

Опубликована: Апрель 10, 2023

Язык: Английский

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TCMBank: bridges between the largest herbal medicines, chemical ingredients, target proteins, and associated diseases with intelligence text mining

Chemical Science, Год журнала: 2023, Номер 14(39), С. 10684 - 10701

Опубликована: Янв. 1, 2023

Traditional Chinese Medicine (TCM) has long been viewed as a precious source of modern drug discovery. AI-assisted discovery (AIDD) investigated extensively. However, there are still two challenges in applying AIDD to guide TCM discovery: the lack large amount standardized TCM-related information and is prone pathological failures out-of-domain data. We have released Database@Taiwan 2011, it widely disseminated used. Now, we developed TCMBank, largest systematic free database, which an extension Database@Taiwan. TCMBank contains 9192 herbs, 61 966 ingredients (unduplicated), 15 179 targets, 32 529 diseases, their pairwise relationships. By integrating multiple data sources, provides 3D structure standard list detailed on ingredients, targets diseases. intelligent document identification module that continuously adds retrieved from literature PubChem. In addition, driven by big data, ensemble learning-based protocol for identifying potential leads repurposing. take colorectal cancer Alzheimer's disease examples demonstrate how accelerate artificial intelligence. Using researchers can view literature-driven relationship mapping between herbs/ingredients genes/diseases, allowing understanding molecular action mechanisms new potentially effective treatments. available at https://TCMBank.CN/.

Язык: Английский

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Roles of Gut Microbiota in Alcoholic Liver Disease

International Journal of General Medicine, Год журнала: 2023, Номер Volume 16, С. 3735 - 3746

Опубликована: Авг. 1, 2023

Abstract: Alcoholic liver disease (ALD)—one of the most common diseases — involves a wide range disorders, including asymptomatic hepatic steatosis, alcoholic hepatitis (AH), fibrosis, and cirrhosis. Alcohol consumption induces weakened gut barrier changes in composition microbiota. The presence CYP2E1 its elevated levels gastrointestinal tract after alcohol exposure lead to ROS acetaldehyde, inducing inflammation oxidative damage gut. At same time, influx harmful molecules such as bacterial endotoxin LPS peptidogly from dysbiosis can induce intestinal damage, further compromising mucosal barrier. In this process, various stress-mediated post-translational modifications (PTMs) play an important role integrity barrier, eg, acetaldehyde will result sustained phosphorylation several paracellular proteins (occludin zona occludens-1), which leakage. Eventually, persistent stress, infiltration hepatocyte through enterohepatic circulation stellate cell activation fibrosis. addition, probiotics, prebiotics, synbiotics, fecal microbial transplantation (FMT), bioengineered bacteria, gut-restricted FXR agonists others are promising therapeutic approaches that alter microbiota improve ALD. future, there be new challenges study interactions between genetics individuals with ALD their microbiome, provide personalized interventions targeting gut-liver axis, develop better techniques measure communities metabolites body. Keywords: disease, dysbiosis, modulators

Язык: Английский

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