Research progress on natural products against hepatocellular carcinoma

Biocell, Год журнала: 2024, Номер 48(6), С. 905 - 922

Опубликована: Янв. 1, 2024

Hepatocellular carcinoma (HCC) remains a prevalent and challenging malignancy globally, characterized by its numerous causal factors generally unfavorable prognosis.In the relentless pursuit of effective treatment modalities, natural products have emerged as promising relatively non-toxic alternative, garnering significant interest.The integration with contemporary medical research has yielded encouraging therapeutic outcomes in management HCC.This review offers comprehensive overview underlying HCC, diverse options available, highlights advancements made anti-HCC research.Particularly, we provide an outline various types products, their corresponding nomenclature, target molecules, mechanisms action that exhibit activities.Natural are anticipated to play pivotal role future plans for liver cancer, potentially offering patients improved survival rates enhanced quality life.

Язык: Английский

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Peanut skin polyphenols inhibit proliferation of leukemia cells in vitro, and its A‐type procyanidins selectively pass through a Caco‐2 intestinal barrier

Journal of Food Science, Год журнала: 2025, Номер 90(2)

Опубликована: Фев. 1, 2025

Abstract Increased consumption of nuts is associated with reduced risk some forms cancer, including leukemia. Peanut skins are not typically retained during food processing but a potential source anticarcinogenic polyphenols. There limited data about the antileukemic activity and bioavailability peanut skin This study determined polyphenol profile raw extract (PSE), its antiproliferative toward Jurkat cells, intestinal metabolism using Caco‐2 monolayer model. High‐resolution mass spectrometry (UHPLC–Q‐Orbitrap) was used to analyze PSE extracts PSE‐treated cells determine polyphenols activity. cell viability, indicating contained at least 63 polyphenols, phenolic acids, proanthocyanidins, prenylated flavonoids, among others. Multiple particularly proanthocyanidins A‐type bonds, interacted cells. In (+)‐catechin, quercetin, procyanidin A2, tentatively A1. metabolized methylation dimer. Thus, these cell‐based studies demonstrate that contain bioavailable properties. were by modulated proanthocyanidins. Practical Application Raw rich in Extracts inhibit growth cultured leukemia this effect. processing, so further research development needed recover or retain compounds document their health‐promoting activities human studies.

Язык: Английский

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Engineered Hollow Nanocomplex Combining Photothermal and Antioxidant Strategies for Targeted Tregs Depletion and Potent Immune Activation in Tumor Immunotherapy

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Abstract In the tumor immunosuppressive microenvironment (TIME), regulatory T cells (Tregs) critically suppress anticancer immunity, characterized by high expression of glucocorticoid‐induced TNF receptor (GITR) and sensitivity to reactive oxygen species (ROS). This study develops a near‐infrared (NIR)‐responsive hollow nanocomplex (HPDA‐OPC/DTA‐1) using polydopamine nanoparticles (HPDA), endowed with thermogenic antioxidative properties, specifically targeting Tregs activate antitumor immunity. The GITR agonist DTA‐1, combined antioxidant oligomeric proanthocyanidins (OPC) deplete Tregs. However, depletion alone may not sufficiently trigger robust immune responses. HPDA nanocarrier enhances capacities, supporting photothermal immunotherapy. HPDA‐OPC/DTA‐1 demonstrates NIR responsiveness for both therapy (PTT) OPC release, while facilitating via DTA‐1 reducing ROS levels, thereby reviving Notably, intratumoral CD4 + CD25 FOXP3 exhibited 4.08‐fold reduction alongside 49.11‐fold increase in CD8 cells/Tregs relative controls. Enhanced dendritic (DCs) maturation immunogenic cell death (ICD) induction further demonstrate that alleviates immunosuppression activates Ultimately, observed inhibitory effect (tumor volume: 6.75‐fold versus control) an over 80% survival rate highlight therapeutic potential combining targeting, strategy, immunotherapy effective cancer treatment.

Язык: Английский

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Peanuts (Arachis hypogea L.) in Food Industry and their Benefits for Human Health – a Review of the Current Literature

Journal of Food Composition and Analysis, Год журнала: 2025, Номер unknown, С. 107574 - 107574

Опубликована: Апрель 1, 2025

Язык: Английский

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Transcriptome and Metabolome Analysis Unveil Anthocyanin Metabolism in Pink and Red Testa of Peanut (Arachis hypogaea L.)

International Journal of Genomics, Год журнала: 2021, Номер 2021, С. 1 - 16

Опубликована: Авг. 6, 2021

Peanut (Arachis hypogaea L.) is an important source of oil and food around the world, testa color affects its appearance commercial value. However, few studies focused on mechanism pigment formation in peanut testa. In this study, cultivars Shanhua 15 with pink Zhonghua 12 red were used as materials to perform combined analysis transcriptome metabolome. A total 198 flavonoid metabolites detected, among which petunidin 3-O-glucoside cyanidin O-acetylhexoside Zhonghua12 15.23 14.72 times higher than those at R7 stage, revealing anthocyanins underlying Transcriptome showed that there 6059 3153 differentially expressed genes between different growth periods, respectively. These significantly enriched biosynthesis, biosynthesis secondary metabolites, metabolic pathways. Integrated metabolome indicated CHS gene (arahy.CM90T6), F3 ′ H (arahy. 8F7PE4 arahy. K8H9R8), DFR LDV9QN X8EVF3) may be key functional controlling peanut. Transcription factors MYB (arahy.A2IWKV, arahy.US2SKM, arahy.SJGE27, arahy.H8DJRL, arahy.PR7AYB), bHLH (arahy.26781N, arahy.HM1IVV, arahy.MP3D3D), WD40 (arahy.L6JJW9) biosynthetic pathway anthocyanin upregulated regulatory formation. This a comprehensive related expression testa, providing reference for accumulation

Язык: Английский

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