Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review

Nutrients, Год журнала: 2025, Номер 17(3), С. 391 - 391

Опубликована: Янв. 22, 2025

Background/Objectives: This systematic review focused on collecting the most significant findings impact of administration Bifidobacterium infantis (or longum subps. infantis) and breve, alone, in conjunction, or combination with other strains, treatment neurodegenerative diseases including Alzheimer’s disease (AD) Parkinson’s (PD). These are characterized by progressive degeneration neurons, resulting a broad spectrum clinical manifestations. AD is typified decline cognitive abilities, while PD marked motor symptoms associated loss dopamine (DA). Methods: Five different databases, ScienceDirect, Scopus, Wiley, PubMed, Web Science (WoS), were reviewed studies screened for inclusion following criteria: (i) that specifically evaluated use infantis, subsp. breve as therapeutic intervention, either human animal models, context diseases; (ii) required to address one more pathologies examined this article, included, but not limited to, neurodegeneration, disease, oxidative stress; (iii) full text was accessible online; (iv) article written English. Results: The data suggest these probiotics have neuroprotective effects may delay progression. Conclusions: study provides updated insights into strains like PD, main limitation being number trials available.

Язык: Английский

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Exosomes in brain diseases: Pathogenesis and therapeutic targets

MedComm, Год журнала: 2023, Номер 4(3)

Опубликована: Июнь 1, 2023

Exosomes are extracellular vesicles with diameters of about 100 nm that naturally secreted by cells into body fluids. They derived from endosomes and wrapped in lipid membranes. involved intracellular metabolism intercellular communication. contain nucleic acids, proteins, lipids, metabolites the cell microenvironment cytoplasm. The contents exosomes can reflect their cells' origin allow observation tissue changes states under disease conditions. Naturally have specific biomolecules act as "fingerprint" parent cells, changed pathological conditions be used biomarkers for diagnosis. low immunogenicity, small size, cross blood-brain barrier. These characteristics make unique engineering carriers. incorporate therapeutic drugs achieve targeted drug delivery. carriers therapy still infancy, but exosome provides a new perspective cell-free therapy. This review discussed relationship occurrence treatment some neuropsychiatric diseases. In addition, future applications diagnosis disorders were evaluated this review.

Язык: Английский

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Potential Exosome Biomarkers for Parkinson’s Disease Diagnosis: A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5307 - 5307

Опубликована: Май 13, 2024

Parkinson’s disease (PD) is the second most common neurodegenerative worldwide. Given its prevalence, reliable biomarkers for early diagnosis are required. Exosomal proteins within extracellular nanovesicles promising candidates diagnostic, screening, prognostic, and monitoring purposes in neurological diseases such as PD. This review aims to evaluate potential of vesicle or miRNAs A comprehensive literature search until January 2024 was conducted across multiple databases, including PubMed, EMBASE, Web Science, Cochrane Library, identify relevant studies reporting exosome blood samples from PD patients. Out 417 articles screened, 47 were selected analysis. Among exosomal protein biomarkers, α-synuclein, tau, Amyloid β 1-42, C-X-C motif chemokine ligand 12 (CXCL12) identified significant markers Concerning miRNA miRNA-24, miR-23b-3p, miR-195-3p, miR-29c, mir-331-5p studies. α-synuclein exhibited increased levels patients compared control groups twenty-one studies, while a decrease observed three Our meta-analysis revealed difference total between healthy controls (standardized mean [SMD] = 1.369, 95% confidence interval [CI] 0.893 1.846, p < 0.001), although these results limited by data availability. Furthermore, significantly differ (SMD 1.471, CI 0.941 2.002, 0.001). In conclusion, certain could serve diagnosis, prognosis prediction, assessment progression

Язык: Английский

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Jaranol alleviates cognitive impairment in db/db mice through the PI3K/AKT pathway

Metabolic Brain Disease, Год журнала: 2025, Номер 40(1)

Опубликована: Янв. 6, 2025

Язык: Английский

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miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson’s disease model via regulation of Nox4/ROS/Nrf2 signaling

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Окт. 24, 2023

Abstract Background The pathogenesis of Parkinson's disease (PD) has not been fully elucidated, and there are no effective disease-modifying drugs for the treatment PD. Mesenchymal stem cells have used to treat several diseases, but readily available. Methods Here, we phenotypically uniform trophoblast stage-derived mesenchymal (T-MSCs) from embryonic cells, which capable stable production, their exosomes (T-MSCs-Exo) explore molecular mechanisms involved in dopaminergic (DA) neuron protection PD models using experimental assays (e.g., western blotting, immunofluorescence immunohistochemistry staining). Results We assessed levels DA injury oxidative stress MPTP-induced mice MPP + -induced MN9D after treating them with T-MSCs or T-MSCs-Exo. Furthermore, T-MSCs-Exo miRNA sequencing analysis revealed that miR-100-5p-enriched directly targeted 3′ UTR NOX4 , could protect against loss neurons, maintain nigro-striatal system function, ameliorate motor deficits, reduce via Nox4-ROS-Nrf2 axis models. Conclusions study suggests may be a promising biological agent Graphical Schematic summary mechanism underlying neuroprotective actions Exo inhibit expression level target gene by delivering miR-100-5p, thereby reducing ROS production alleviating axis, thus improving damage

Язык: Английский

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Physiological and pathological functions of circular RNAs in the nervous system

Neural Regeneration Research, Год журнала: 2023, Номер 19(2), С. 342 - 349

Опубликована: Июль 7, 2023

Abstract Circular RNAs (circRNAs) are a class of covalently closed single-stranded that expressed during the development specific cells and tissues. CircRNAs play crucial roles in physiological pathological processes by sponging microRNAs, modulating gene transcription, controlling activity certain RNA-binding proteins, producing functional peptides. A key focus research at present is functionality circRNAs nervous system several advances have emerged over last 2 years. However, precise role has yet to be comprehensively reviewed. In this review, we first summarize recently described brain development, maturity, aging. Then, on involvement various diseases central system, such as cancer, chronic neurodegenerative diseases, acute injuries neuropathic pain. better understanding will help us develop potential diagnostic, prognostic, therapeutic strategies treat system.

Язык: Английский

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iCircDA-NEAE: Accelerated attribute network embedding and dynamic convolutional autoencoder for circRNA-disease associations prediction

PLoS Computational Biology, Год журнала: 2023, Номер 19(8), С. e1011344 - e1011344

Опубликована: Авг. 31, 2023

Accumulating evidence suggests that circRNAs play crucial roles in human diseases. CircRNA-disease association prediction is extremely helpful understanding pathogenesis, diagnosis, and prevention, as well identifying relevant biomarkers. During the past few years, a large number of deep learning (DL) based methods have been proposed for predicting circRNA-disease achieved impressive performance. However, there are two main drawbacks to these methods. The first underutilize biometric information data. Second, features extracted by not outstanding represent characteristics between In this study, we developed novel model, named iCircDA-NEAE, predict associations. particular, use disease semantic similarity, Gaussian interaction profile kernel, circRNA expression Jaccard similarity simultaneously time, extract hidden on accelerated attribute network embedding (AANE) dynamic convolutional autoencoder (DCAE). Experimental results circR2Disease dataset show iCircDA-NEAE outperforms other competing significantly. Besides, 16 top 20 pairs with highest scores were validated literature. Furthermore, observe can effectively new potential

Язык: Английский

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The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson’s disease

Cellular & Molecular Biology Letters, Год журнала: 2024, Номер 29(1)

Опубликована: Янв. 3, 2024

Abstract Background Parkinson’s disease (PD) affects 1% of people over 60, and long-term levodopa treatment can cause side effects. Early diagnosis is great significance in slowing down the pathological process PD. Multiple pieces evidence showed that non-coding RNAs (ncRNAs) could participate progression PD pathology. Pyroptosis known to be regulated by ncRNAs as a key feature Therefore, evaluating pyroptosis-related proteins serum worthy biomarkers for early Methods NcRNAs pyroptosis/inflammation mRNA levels were measured with reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). Luciferase assays performed confirm GSDME target miR-675-5p HMGB1 miR-1247-5p. In healthy controls ( n = 106) patients 104), RT-qPCR was utilized assess miR-675-5p, miR-1247-5p, two related (circSLC8A1and lncH19) levels. The enzyme-linked immunosorbent assay 54) 70). Results Our data demonstrated miR-1247-5p significantly changed neuron animal models. Overexpressed or downregulated regulate pyroptosis inflammation Using random forest algorithm, we constructed classifier based on neuron-pyroptosis pathology (four six proteins) having better predictive power than single (AUC 92%). Additionally, verified performance early-stage ≥ 88%). Conclusion Serum serve reliable, inexpensive, non-invasive diagnostic Limitations All participants from same region. longitudinal studies aged population are required explore practical application value classifier.

Язык: Английский

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Role of Exosomes in the Pathogenesis and Theranostic of Alzheimer’s Disease and Parkinson’s Disease

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 11054 - 11054

Опубликована: Июль 4, 2023

Alzheimer’s disease (AD) and Parkinson’s (PD) are the most common neurodegenerative diseases (NDDs) threatening lives of millions people worldwide, including especially elderly people. Currently, due to lack a timely diagnosis proper intervention strategy, AD PD largely remain incurable. Innovative therapy highly desired. Exosomes small vesicles that present in various bodily fluids, which contain proteins, nucleic acids, active biomolecules, play crucial role intercellular communication. In recent years, exosomes pathogenesis, early diagnosis, treatment has attracted ascending attention. However, exact pathogenesis theragnostic not been fully illustrated. review, we first introduce biogenesis, components, uptake, function exosomes. Then elaborate on involvement PD. Moreover, application therapeutics is also summarized discussed. Additionally, serving as drug carriers deliver medications central nervous system specifically addressed. The potential explored, discussing their applications treatment, well current limitations. Given limitation exosomes, propose future perspectives for better utilizing NDDs. Hopefully, it would pave ways expanding biological fundamental research theranostics

Язык: Английский

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Cut&tag: a powerful epigenetic tool for chromatin profiling

Epigenetics, Год журнала: 2023, Номер 19(1)

Опубликована: Дек. 17, 2023

Analysis of transcription factors and chromatin modifications at the genome-wide level provides insights into gene regulatory processes, such as transcription, cell differentiation cellular response. Chromatin immunoprecipitation is most popular powerful approach for mapping chromatin, other enzyme-tethering techniques have recently become available living cells. Among these, Cleavage Under Targets Tagmentation (CUT&Tag) a relatively novel profiling method that has rapidly gained popularity in field epigenetics since 2019. It also been widely adapted to map TFs different species, illustrating association these epitopes with various physiological pathological processes. Scalable single-cell CUT&Tag can be combined distinct platforms distinguish identity, epigenetic features even spatial profiling. In addition, developed strategy joint epigenome, transcriptome or proteome on same sample. this review, we will mainly consolidate applications its derivatives platforms, give detailed explanation pros cons technique well potential development trends future.

Язык: Английский

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