Life Sciences, Год журнала: 2023, Номер 321, С. 121643 - 121643
Опубликована: Март 28, 2023
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 163, С. 114834 - 114834
Опубликована: Май 8, 2023
Osteoporosis is becoming a major concern in the field of public health. The process bone loss insidious and does not directly induce obvious symptoms. Complications indicate an irreversible decrease mass. high-risk populations osteoporosis, including postmenopausal women, elderly men, diabetic patients obese individuals need regular mineral density testing appropriate preventive treatment. However, primary changes these are different, increasing difficulty effective treatment osteoporosis. Determining core pathogenesis osteoporosis helps improve efficiency efficacy among populations. Oxidative stress common pathological state secondary to estrogen deficiency, aging, hyperglycemia hyperlipemia. In this review, we divided oxidative into direct effect reactive oxygen species (ROS) reduction antioxidant enzyme activity discuss their roles development ROS initiated mitochondrial apoptotic signaling suppressed osteogenic marker expression weaken osteogenesis. MAPK NF-κB pathways mediated positive on osteoclast differentiation. Antioxidant enzymes only eliminate negative effects ROS, but also participate regulation metabolism. Additionally, described proinflammatory factors HIF-1α under pathophysiological inflammation hypoxia, which provided supplement stress-induced conclusion, our review showed that was population for Targeted would greatly optimize therapeutic schedule various treatments.
Язык: Английский
Процитировано
81
Antioxidants and Redox Signaling, Год журнала: 2023, Номер 38(13-15), С. 974 - 988
Опубликована: Март 17, 2023
Significance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative such as Alzheimer's disease, Parkinson's multiple sclerosis. Nuclear factor erythroid 2-related 2 (NRF2) is a transcription belonging to cap-n-collar family that harbors unique basic leucine zipper motif plays master regulator homeostatic responses. Recent Advances: Kelch-like ECH-associated protein 1 (KEAP1) an adaptor Cullin3 (CUL3)-based ubiquitin E3 ligase enhances ubiquitylation NRF2, which promotes degradation NRF2 suppress its transcriptional activity in absence stress. Cysteine residues KEAP1 modified under stress conditions, attenuated, allowing it accumulate induce expression target genes. This regulatory referred KEAP1-NRF2 central role protecting cells against various stresses. also negatively regulates inflammatory cytokine chemokine genes suppresses pathological inflammation. As oxidative stress, inflammation, proteostasis known contribute diseases, attractive for treatment these diseases. Critical Issues: In mouse models Nrf2 depletion exacerbates symptoms damage inflammation CNS. contrast, chemical or genetic activation improves symptoms. Indeed, NRF2-activating dimethyl fumarate now widely used clinical MS. Future Directions: The promising therapeutic
Язык: Английский
Процитировано
58
Pharmacological Research, Год журнала: 2023, Номер 190, С. 106710 - 106710
Опубликована: Март 4, 2023
Diabetic kidney disease (DKD) is the first cause of end-stage in patients with diabetes and its prevalence increasing worldwide. It encompasses histological alterations that mainly affect glomerular filtration unit, which include thickening basement membrane, mesangial cell proliferation, endothelial alteration, podocyte injury. These morphological abnormalities further result a persistent increase urinary albumin-to-creatinine ratio reduction estimated rate. Several molecular cellular mechanisms have been recognized, up to date, as major players mediating such clinical features many more are being under investigation. This review summarizes most recent advances understanding death mechanisms, intracellular signaling pathways effectors play role onset progression diabetic damage. Some those already successfully targeted preclinical models DKD and, some cases, strategies tested trials. Finally, this report sheds light on relevance novel may become therapeutic targets for future applications DKD.
Язык: Английский
Процитировано
29
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6053 - 6053
Опубликована: Март 23, 2023
Redox is a constant phenomenon in organisms. From the signaling pathway transduction to oxidative stress during inflammation and disease process, all are related reduction-oxidation (redox). Nuclear factor erythroid 2-related 2 (NRF2) transcription targeting many antioxidant genes. In non-stressed conditions, NRF2 maintains hemostasis of redox with housekeeping work. It expresses constitutively basal activity, maintained by Kelch-like-ECH-associated protein 1 (KEAP1)-associated ubiquitination degradation. When encountering stress, it can be up-regulated several mechanisms exert its anti-oxidative ability diseases or inflammatory processes protect tissues organs from further damage. acute kidney injury chronic diseases, such as diabetic nephropathy glomerular disease, results studies have suggested that, master regulating redox, therapeutic option. was not until early termination clinical phase 3 trial due heart failure an unexpected side effect that we renewed our understanding NRF2. just simple capacity but has pleiotropic activities, harmful helpful, depending on conditions backgrounds.
Язык: Английский
Процитировано
28
Frontiers in Microbiology, Год журнала: 2023, Номер 14
Опубликована: Июль 27, 2023
Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which increases the risk renal failure and causes high global disease burden. Due to lack sustainable treatment, DN has become primary cause end-stage worldwide. Gut microbiota its metabolites exert critical regulatory functions in maintaining host health are associated with many pathogenesis aging-related chronic diseases. Currently, theory gut–kidney axis opened novel angle understand relationship between gut multiple kidney In recent years, accumulating evidence revealed that their play an essential role pathophysiologic processes through axis. this review, we summarize current investigations microbial involvement progression DN, further discuss potential microbiota-targeted therapeutic approaches for DN.
Язык: Английский
Процитировано
26
Physiological Reports, Год журнала: 2024, Номер 12(5)
Опубликована: Фев. 28, 2024
Abstract The role of NRF2 in kidney biology has received considerable interest over the past decade. transcriptionally controls genes responsible for cellular protection against oxidative and electrophilic stress anti‐inflammatory functions. is expressed throughout plays a salt water handling. In disease, animal studies show that protects tubulointerstitial damage reduces interstitial fibrosis tubular atrophy, may slow progression polycystic disease. However, proteinuric glomerular diseases controversial. Although inducer, bardoxolone methyl (CDDO‐Me), increases filtration rate humans, it not been shown to disease diabetic Alport syndrome. Furthermore, was associated with negative effects on fluid retention, proteinuria, blood pressure. Several replicate findings worsened proteinuria more rapid although controversy exists. It clear further study needed better understand kidney. This review summarizes available data clarify promise risks targeting activity
Язык: Английский
Процитировано
12
Cellular & Molecular Biology Letters, Год журнала: 2024, Номер 29(1)
Опубликована: Март 2, 2024
Abstract Exosomes are nano-sized membrane extracellular vesicles which can be released from various types of cells. originating inflammatory or injured cells have detrimental effects on recipient cells, while exosomes derived stem not only facilitate the repair and regeneration damaged tissues but also inhibit inflammation provide protective against diseases, suggesting they may serve as an alternative strategy transplantation. a fundamental role in communication between through transfer proteins, bioactive lipids nucleic acids (like miRNAs mRNAs) This significantly impacts both physiological pathological functions Nuclear factor erythroid 2–related 2 (Nrf2), transcription factor, is able to mitigate damage caused by oxidative stress signaling pathways. The positive resulting activation Nrf2 pathway different disorders been documented literature. Studies confirmed that could act effective agonists. However, limited studies explored therapeutic cell-derived exosomes. review provides comprehensive overview existing knowledge concerning pathways impact exerted cell some common diseases. Graphical
Язык: Английский
Процитировано
8
Journal of Ethnopharmacology, Год журнала: 2024, Номер 333, С. 118424 - 118424
Опубликована: Июнь 4, 2024
Язык: Английский
Процитировано
6
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 477 - 477
Опубликована: Янв. 8, 2025
Due to advances in big data technology, deep learning, and knowledge engineering, biological sequence visualization has been extensively explored. In the post-genome era, enables visual representation of both structured unstructured data. However, a universal method for all types sequences not reported. Biological are rapidly expanding exponentially acquisition, extraction, fusion, inference from critical supporting technologies research. These areas important require in-depth exploration. This paper elaborates on comprehensive overview methods DNA four different perspectives-two-dimensional, three-dimensional, four-dimensional, dynamic approaches-and discusses strengths limitations each detail. Furthermore, this proposes two potential future research directions response challenges inefficient graphical feature extraction association network generation existing methods. The first direction is construction graphs data, second cross-modal using machine learning review anticipated provide valuable insights contributions computational biology, bioinformatics, genomic computing, genetic breeding, evolutionary analysis, other related disciplines fields medicine, chemistry, statistics, computing. It an reference value recommendation systems question answering systems.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 10, 2025
Abstract Skin, as the first line of defence human body, is exposed to dangers such overheating substances, ultraviolet rays, and environmental pollutants, incidence skin diseases increasing annually. Oxidative stress plays a dominant role in most diseases. Abelmoschus manihot (L.) medic flower (TEA) traditional Chinese medicine widely used treat injuries water fire scalds. It has been reported that TEA excellent antioxidant effects. In this study, we aimed explore mitochondrial protection effects H 2 O -mediated HaCaT cell damage. cells were incubated with simulate oxidative skin. The effect on was also evaluated. Cell morphology observed via inverted microscopy, viability measured MTT reagent. stained Hoechst 33,324 solution. Reactive oxygen species (ROS), superoxide dismutase (SOD), malondialdehyde (MDA) ATP detection kits detect corresponding indicators. membrane potential detected by JC-1. RT-PCR mRNA mtDNA expression. expression target protein Western blotting immunofluorescence. triggered damage cells, which manifested apoptosis, increased ROS MDA contents, decreased SOD activity. activates KEAP1/Nrf2/NQO1 signalling pathway, decreases intracellular KEAP1 slightly increases Nrf2 NQO1 proteins, further causing stress, resulting changes potential, reduction copy number, PGC-1α TFAM proteins. addition respiratory chain genes proteins decreased. promoted activated downstream response, alleviated caused . ML385 an inhibitor, under protective are inhibited. When knocked down, mitochondria protects from -induced through KEAP1/Nrf2/NQO1/PGC-1α/TFAM pathway.
Язык: Английский
Процитировано
0