Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(6), С. 2040 - 2040
Опубликована: Март 17, 2025
Oncologists
increasingly
recognize
the
microbiome
as
an
important
facilitator
of
health
well
a
contributor
to
disease,
including,
specifically,
cancer.
Our
knowledge
etiologies,
mechanisms,
and
modulation
states
that
ameliorate
or
promote
cancer
continues
evolve.
The
progressive
refinement
adoption
“omic”
technologies
(genomics,
transcriptomics,
proteomics,
metabolomics)
utilization
advanced
computational
methods
accelerate
this
evolution.
academic
center
network,
with
its
immediate
access
extensive,
multidisciplinary
expertise
scientific
resources,
has
potential
catalyze
research.
Here,
we
review
our
current
understanding
role
gut
in
prevention,
predisposition,
response
therapy.
We
underscore
promise
operationalizing
network
uncover
structure
function
microbiome;
highlight
unique
microbiome-related
expert
resources
available
at
City
Hope
Comprehensive
Cancer
Center
example
team
science
achieve
novel
clinical
discovery.
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
19(4)
Опубликована: Янв. 17, 2024
Abstract
Malignant
tumors
seriously
threaten
human
life
and
well‐being.
Emerging
Near‐infrared
II
(NIR‐II,
1000–1700
nm)
phototheranostic
nanotechnology
integrates
diagnostic
treatment
modalities,
offering
merits
including
improved
tissue
penetration
enhanced
spatiotemporal
resolution.
This
remarkable
progress
has
opened
promising
avenues
for
advancing
tumor
theranostic
research.
The
microenvironment
(TME)
differs
from
normal
tissues,
exhibiting
distinct
attributes
such
as
hypoxia,
acidosis,
overexpressed
hydrogen
peroxide,
excess
glutathione,
other
factors.
Capitalizing
on
these
attributes,
researchers
have
developed
TME‐activatable
NIR‐II
agents
with
therapeutic
concurrently.
Therefore,
developing
activation
holds
significant
research
importance.
Currently,
is
still
in
its
preliminary
stages.
review
examines
the
recent
advances
dual‐functional
activatable
over
past
years.
It
systematically
presents
activated
by
various
TME
factors
acidity
(pH),
peroxide
(H
2
O
),
glutathione
(GSH),
sulfide
S),
enzymes,
their
hybrid.
encompasses
fluorescence
photoacoustic
imaging
diagnostics,
along
photothermal,
photodynamic,
chemodynamic,
gas
therapies
triggered
Lastly,
difficulties
opportunities
confronting
simultaneous
diagnosis
field
are
highlighted.
Chemical Science,
Год журнала:
2024,
Номер
15(16), С. 6028 - 6035
Опубликована: Янв. 1, 2024
Drug
resistance
is
a
major
challenge
for
cancer
treatment,
and
its
identification
crucial
medical
research.
However,
since
drug
multi-faceted
phenomenon,
it
important
to
simultaneously
evaluate
multiple
target
fluctuations.
Recently
developed
fluorescence-based
probes
that
can
respond
targets
offer
many
advantages
real-time
in
situ
monitoring
of
cellular
metabolism,
including
ease
operation,
rapid
reporting,
their
non-invasive
nature.
As
such
we
dual-response
platform
(Vis-H2S)
with
integrated
ICT-TICT
image
H2S
viscosity
mitochondria,
which
could
track
fluctuations
cysteine
desulfurase
(NFS1
protein
inducer)
autophagy
during
chemotherapy-induced
multidrug
resistance.
This
monitor
endogenous
metabolites
the
synergistic
relationship
between
NFS1
induced
by
chemotherapy.
The
results
indicated
chemotherapeutic
drugs
up-regulate
levels
autophagy.
It
was
also
found
linked
autophagy,
eventually
led
such,
this
serve
as
an
effective
tool
in-depth
exploration
mechanisms.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2025,
Номер
44(1)
Опубликована: Янв. 29, 2025
Abstract
Background
Bacterial
toxins
are
emerging
as
promising
hallmarks
of
colorectal
cancer
(CRC)
pathogenesis.
In
particular,
Cytotoxic
Necrotizing
Factor
1
(CNF1)
from
E.
coli
deserves
special
consideration
due
to
the
significantly
higher
prevalence
this
toxin
gene
in
CRC
patients
with
respect
healthy
subjects,
and
numerous
tumor-promoting
effects
that
have
been
ascribed
vitro.
Despite
evidence,
a
definitive
causal
link
between
CNF1
was
missing.
Here
we
investigated
whether
plays
an
active
role
onset
by
analyzing
pro-carcinogenic
key
specifically
induced
vitro
vivo.
Methods
Viability
assays,
confocal
microscopy
γH2AX
53BP1
molecules
cytogenetic
analysis
were
carried
out
assess
CNF1-induced
genotoxicity
on
non-neoplastic
intestinal
epithelial
cells.
Caco-2
monolayers
3D
spheroids
used
evaluate
permeability
alterations
CNF1,
either
presence
or
absence
inflammation.
vivo,
inflammatory
bowel
disease
(IBD)
model
exploited
carcinogenic
potential
CNF1.
Immunohistochemistry
immunofluorescence
stainings
formalin-fixed
paraffin-embedded
(FFPE)
colon
tissue
well
fecal
microbiota
composition
16
S
rRNA
sequencing.
Results
induces
release
reactive
oxidizing
species
chromosomal
instability
addition,
modifies
directly
altering
tight
junctions’
distribution
2D
monolayers,
hindering
differentiation
irregular
arrangement
these
junctions.
repeated
intrarectal
administration
formation
dysplastic
aberrant
crypt
foci
(ACF),
produces
adenomas
IBD
model.
These
accompanied
increased
neutrophilic
infiltration
colonic
tissue,
mixed
pro-inflammatory
anti-inflammatory
cytokine
milieu,
pro-tumoral
modulation
microbiota.
Conclusions
Taken
together,
our
results
support
hypothesis
carcinogenesis.
Altogether,
findings
not
only
add
new
knowledge
contribution
bacterial
CRC,
but
also
pave
way
implementation
current
screening
programs
preventive
strategies.
Cell Reports,
Год журнала:
2025,
Номер
44(3), С. 115358 - 115358
Опубликована: Март 1, 2025
SummaryThe
human
microbiome,
an
intricate
ecosystem
of
trillions
microbes
residing
across
various
body
sites,
significantly
influences
cancer,
a
leading
cause
morbidity
and
mortality
worldwide.
Recent
studies
have
illuminated
the
microbiome's
pivotal
role
in
cancer
development,
either
through
direct
cellular
interactions
or
by
secreting
bioactive
compounds
such
as
metabolites.
Microbial
metabolites
contribute
to
initiation
mechanisms
DNA
damage,
epithelial
barrier
dysfunction,
chronic
inflammation.
Furthermore,
microbial
exert
dual
roles
on
progression
response
therapy
modulating
metabolism,
gene
expression,
signaling
pathways.
Understanding
these
complex
is
vital
for
devising
new
therapeutic
strategies.
This
review
highlights
promising
targets
prevention
treatment,
emphasizing
their
impact
responses
underscoring
need
further
research
into
metastasis
resistance.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 1, 2025
Late-stage
and
advanced
colorectal
cancer
(CRC)
often
prove
to
be
resistant
current
treatment
regimens,
due
the
evolving
tumor
microenvironment.
Chemotherapy-dominated
multi-modal
therapeutic
strategies
based
on
specific
CRC
microenvironment
open
a
new
horizon
for
eradicating
tumors.
Here,
in
situ
valence-transited
arsenic
nanosheets
are
developed
as
platform
by
responding
H2S-enriched
Carrier-free
pegylated
of
pentavalent
(AsV),
aminooxyacetic
acid
(AOAA),
copper
ion
(Cu2+)
innovatively
self-assembled
via
coordination
with
high
loading
content
good
stability.
AsV
(CAA-PEG
NSs)
is
rapidly
released
reduced
trivalent
(AsIII)
exert
its
chemotherapy
local
tumor.
Furthermore,
immunosuppressive
thoroughly
remodeled
H2S
depletion
AsIII
conversion
impairment
production
AOAA.
Additionally,
produced
ultrasmall
CuS
nanoparticles
exhibit
photothermal
activity
against
under
guidance
photoacoustic
imaging.
This
strategy,
dominated
chemotherapy,
completely
inhibits
progression
prevents
relapse.
strategy
has
potential
Here
this
group
reports
using
arsenic-derived
depleting
enriching
while
eliciting
activity/cytotoxicity
cells.
