Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(8)
Опубликована: Авг. 12, 2024
Alzheimer’s
disease
(AD)
is
recognized
as
the
leading
cause
of
dementia,
imposing
a
significant
economic
toll
on
society.
Despite
emergence
novel
therapeutic
approaches
for
AD,
their
efficacy
and
safety
mandates
further
validation
through
rigorous
clinical
trials.
In
this
context,
hypertension
(HTN)
has
garnered
considerable
attention
an
amendable
risk
factor
AD.
Research
indicates
that
during
midlife
associated
with
elevated
AD
in
later
years,
influencing
both
onset
progression
disease.
Nevertheless,
relationship
between
stages
life
remains
subject
debate.
Moreover,
consequences
blood
pressure
reduction
cognitive
function,
along
optimal
pharmacological
interventions
thresholds
hypertension,
have
emerged
pivotal
areas
inquiry.
This
review
synthesizes
findings
epidemiology,
neuroimaging,
biomarkers,
effects
antihypertensive
medications
to
elucidate
link
performance.
We
particularly
investigate
how
are
related
by
plasma
sulfide
dysregulation,
offering
possible
indicators
future
diagnosis
therapy.
Cells,
Год журнала:
2023,
Номер
12(13), С. 1691 - 1691
Опубликована: Июнь 22, 2023
Ever
since
its
presence
was
reported
in
the
brain,
nature
and
role
of
hydrogen
sulfide
(H2S)
Central
Nervous
System
(CNS)
have
changed.
Consequently,
H2S
has
been
elected
as
third
gas
transmitter,
along
with
carbon
monoxide
nitric
oxide,
a
number
studies
focused
on
neuromodulatory
protectant
functions
physiological
conditions.
The
research
highlighted
many
facets
periphery
CNS,
double-faced
compound,
switching
from
protective
to
toxic
depending
concentration.
In
this
review,
we
will
focus
bell-shaped
an
angiogenic
factor
molecule
released
by
glial
cells
(mainly
astrocytes)
non-neuronal
acting
surrounding
environment
(paracrine)
or
releasing
themselves
(autocrine).
Finally,
discuss
Amyotrophic
Lateral
Sclerosis,
paradigm
neurodegenerative
disease.
The Science of The Total Environment,
Год журнала:
2023,
Номер
912, С. 168886 - 168886
Опубликована: Ноя. 26, 2023
Sargassum
invasion
of
Caribbean
and
American
shorelines
is
a
recurring
environmental
hazard.
Potential
health
effects
long-term
chronic
exposure
to
sargassum
gaseous
emissions,
notably
hydrogen
sulfide
(H2S),
are
overlooked.
H2S
plays
an
important
role
in
neurotransmission
involved
generating
transmitting
respiratory
rhythm.
Central
sleep
apnea
(CSA)
has
been
attributed
the
depression
centers.
Evaluate
sargassum-H2S
on
CSA.
This
study,
set
Caribbean,
describes
clinical
polysomnographic
characteristics
individuals
living
and/or
working
areas
impacted
by
strandings,
comparison
with
non-exposed
subjects.
Environmental
was
estimated
closest
ground
sensor.
Multivariate
linear
regression
applied
analyze
CSA
changes
according
cumulative
over
time.
Effects
air
pollution
other
toxic
compounds
(NH3)
were
also
controlled.
Among
685
study
patients,
27
%
areas.
Compared
exposed
ones
had
similar
syndrome
risk
factors,
but
increased
levels
events
(expressed
as
absolute
number
or
total
apnea).
retained
only
male
gender
mean
concentration
6-month
period
independent
predictors
increase
events.
A
minimal
length
1
month
generated
significant
rise
events,
latter
increasing
proportionally
pioneer
work
highlights
potential
effect
central
nervous
system,
modulation
activity
brain's
control
center.
These
observations,
jointly
previous
studies
from
our
group,
constitute
body
evidence
strongly
supporting
deleterious
chronically
low
moderate
Journal of Integrative Neuroscience,
Год журнала:
2024,
Номер
23(8)
Опубликована: Авг. 12, 2024
Alzheimer’s
disease
(AD)
is
recognized
as
the
leading
cause
of
dementia,
imposing
a
significant
economic
toll
on
society.
Despite
emergence
novel
therapeutic
approaches
for
AD,
their
efficacy
and
safety
mandates
further
validation
through
rigorous
clinical
trials.
In
this
context,
hypertension
(HTN)
has
garnered
considerable
attention
an
amendable
risk
factor
AD.
Research
indicates
that
during
midlife
associated
with
elevated
AD
in
later
years,
influencing
both
onset
progression
disease.
Nevertheless,
relationship
between
stages
life
remains
subject
debate.
Moreover,
consequences
blood
pressure
reduction
cognitive
function,
along
optimal
pharmacological
interventions
thresholds
hypertension,
have
emerged
pivotal
areas
inquiry.
This
review
synthesizes
findings
epidemiology,
neuroimaging,
biomarkers,
effects
antihypertensive
medications
to
elucidate
link
performance.
We
particularly
investigate
how
are
related
by
plasma
sulfide
dysregulation,
offering
possible
indicators
future
diagnosis
therapy.
