Hyperoside improves intestinal mucosal immunity against zearalenone-induced intestinal barrier damage by regulating intestinal flora

Veterinary Immunology and Immunopathology, Год журнала: 2025, Номер 285, С. 110949 - 110949

Опубликована: Май 20, 2025

Язык: Английский

---

Application of Natural Products in Neurodegenerative Diseases by Intranasal Administration: A Review

Pharmaceutics, Год журнала: 2025, Номер 17(5), С. 675 - 675

Опубликована: Май 20, 2025

Natural products derived from traditional Chinese medicine have received significant attention as potential treatments for neurodegenerative disorders due to their wide availability, demonstrated efficacy, and favorable safety profiles. Intranasal delivery provides distinct advantages targeting the central nervous system (CNS), enabling direct therapeutic agent brain by bypassing blood-brain barrier (BBB). This review evaluates natural administered intranasally diseases (NDs), highlighting addressing formulation challenges related physicochemical properties. Strategic optimization approaches are proposed, including novel carrier systems, molecular modifications, combination therapies. By discussing current difficulties offering practical recommendations, this aims encourage further scholarly research clinical application.

Язык: Английский

---

Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Май 23, 2025

Neurodegenerative diseases are a class of conditions with widespread detrimental impacts, currently lacking effective therapeutic drugs. Recent studies have identified mitochondrial dysfunction and the resultant oxidative stress as crucial contributors to pathogenesis neurodegenerative diseases. Polyphenols, naturally occurring compounds inherent antioxidant properties, demonstrated potential target mitochondria mitigate stress. This has garnered significant attention in recent years. Investigating targeting capacity polyphenols, their role functional regulation, ability modulate stress, along exploring novel technologies strategies for modifying polyphenol formulations, holds promise providing new avenues treatment

Язык: Английский

---

Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease

Neural Regeneration Research, Год журнала: 2024, Номер 19(11), С. 2467 - 2479

Опубликована: Янв. 31, 2024

JOURNAL/nrgr/04.03/01300535-202419110-00027/figure1/v/2024-03-08T184507Z/r/image-tiff Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer's disease. Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases, including Parkinson's and Huntington's however, the effect of disease remains unelucidated. In current study, anti-apoptotic autophagic roles extract amyloid-beta-induced apoptosis PC12 cells were first investigated. protected from by attenuating Bax/Bcl-2 ratio via activation autophagy. addition, was confirmed bind amyloid-beta as revealed biolayer interferometry vitro, suppress pathology such paralysis, a transgenic Caenorhabditis elegans vivo model. Moreover, genetically defective further that neuroprotective autophagy-dependent. Most importantly, improve impairment, injury burden 3×Tg mice. As both vitro models, these results suggest is potential natural therapeutic agent for its effects.

Язык: Английский

---

Neuroprotective Effect of Codonopsis pilosula Polysaccharide on Aβ25-35-Induced Damage in PC12 Cells via the p38MAPK Signaling Pathways

Pharmaceuticals, Год журнала: 2024, Номер 17(9), С. 1231 - 1231

Опубликована: Сен. 18, 2024

Objectives: Plant polysaccharides have attracted increasing attention due to their high efficiency and low toxicity. Codonopsis pilosula polysaccharide (CPP) is an essential substance extracted from pilosula, known for its excellent antioxidant neuroprotective effects. However, it still unclear how CPP improves nerve protection what underlying molecular mechanisms are. This study aimed investigate the effect of on Aβ25-35-induced damage in PC12 cells mechanisms. Methods: The was evaluated using pheochFfromocytoma (PC12) as vitro cell model. were treated with alone or combination SB203580 (an inhibitor p38MAPK) Aβ25-35 culture. viability assessed a 3-(4,5-Dimethylthiazol-2-yl)-2,diphenyltetrazolium (MTT) assay. Furthermore, reactive oxygen species (ROS) detected flow cytometry. production levels intracellular superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), malondialdehyFde (MDA) determined colorimetric method. Annexin V-FITC propidium iodide (PI) staining, well 33258 performed fluorescence microscopy. Moreover, adding studied determine changes apoptosis induced by treatment induction. Results: markedly inhibited reduction cells. also reduced increase expression factors free radicals (ROS MDA) reversed suppression activity. Additionally, inhibition p38MAPK via addition antagonists observed anti-apoptosis effects CPP. Conclusions: can efficiently provide neuroprotection against brought about oxidation reactions, involve pathways. Therefore, could potentially be useful agent natural medicine, pharmacy, food industry.

Язык: Английский

---

Response Surface Methodology Optimization of Exosome-like Nanovesicles Extraction from Lycium ruthenicum Murray and Their Inhibitory Effects on Aβ-Induced Apoptosis and Oxidative Stress in HT22 Cells

Foods, Год журнала: 2024, Номер 13(20), С. 3328 - 3328

Опубликована: Окт. 20, 2024

Exosome-like nanovesicles (ELNs) derived from plants are nanoscale vesicles isolated edible plant sources. Lycium ruthenicum Murray (LRM) has garnered growing attention for its dietary value and therapeutic benefits. In this study, a PEG6000-based method was developed to isolate LRM-ELNs. Response surface methodology (RSM) used optimize the extraction conditions obtain optimal efficiency. When PEG6000 concentration at 11.93%, relative centrifugal force 9720 g, incubation time 21.12 h, maximum LRM-ELN yield 4.24 g/kg. This optimization process yielded LRM-ELNs with particle size of 114.1 nm charge −6.36 mV. Additionally, mitigated Aβ-induced apoptosis in HT22 cells by enhancing mitochondrial membrane potential (MMP), lowering Bax/Bcl-2 ratio, reducing Cleaved Caspase-3 expression. Furthermore, alleviated oxidative stress promoting nuclear translocation Nrf2 upregulating expression HO-1 NQO1. These findings indicate that exert protective effects against damage may be considered as supplement Alzheimer’s disease prevention.

Язык: Английский

---

Hyperoside attenuates sepsis-induced acute lung injury by Nrf2 activation and ferroptosis inhibition

International Immunopharmacology, Год журнала: 2024, Номер 145, С. 113734 - 113734

Опубликована: Дек. 10, 2024

Язык: Английский

---

Research Progress on Natural Plant Molecules in Regulating the Blood–Brain Barrier in Alzheimer’s Disease

Molecules, Год журнала: 2023, Номер 28(22), С. 7631 - 7631

Опубликована: Ноя. 16, 2023

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder. With the aging population and continuous development of risk factors associated with AD, it will impose significant burden on individuals, families, society. Currently, commonly used therapeutic drugs such as Cholinesterase inhibitors, N-methyl-D-aspartate antagonists, multiple AD pathology removal have been shown to beneficial effects certain pathological conditions AD. However, their clinical efficacy minimal they are adverse reactions. Furthermore, underlying mechanism remains unclear, posing challenge for drug development. In contrast, natural plant molecules, widely available, offer targeting pathways demonstrate inherent advantages in modifying typical pathologic features by influencing blood–brain barrier (BBB). We provide comprehensive review recent vivo vitro studies molecules that impact BBB treatment Additionally, we analyze specific mechanisms novel insights safe effective targeted well guidance experimental research application prevention

Язык: Английский

---

An in situ-activated and chemi-excited photooxygenation system based on G-poly(thioacetal) for Aβ1-42 aggregates

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(42), С. 10850 - 10860

Опубликована: Янв. 1, 2024

BD-6-QM/NPs are chemically activated by H 2 O to produce 1 , inhibit Aβ 1–42 aggregation, promote BV2 phagocytosis of and alleviate -induced neurotoxicity.

Язык: Английский

---

Wave type fiber SPR sensor for rapid and highly sensitive detection of hyperoside

Biomedical Optics Express, Год журнала: 2024, Номер 15(6), С. 3859 - 3859

Опубликована: Май 15, 2024

The fiber surface plasmon resonance (SPR) sensor used for the detection of active ingredients in traditional Chinese medicine has problems low sensitivity and difficult specific recognition. This paper proposed a wave type SPR sensor, which reduced mode transmitted light through periodic structure caused concentrated total reflection beam at interface between bent peak cladding air. A 50 nm gold film was coated on area to form sensing area. By controlling width height control angle light, i.e., incidence angle, effectively improved 4972 nm/RIU. Furthermore, HSP90AA protein modified achieve hyperoside. longest single time only 3 minutes, 0.53 nm/(µg/ml), with limit as 0.68µg/ml, is comparable liquid chromatography. fast production high structural mechanical strength, providing new approach rapid, highly sensitive, medicine.

Язык: Английский

---