Multienzyme Active Manganese Oxide Alleviates Acute Liver Injury by Mimicking Redox Regulatory System and Inhibiting Ferroptosis

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(11)

Опубликована: Янв. 19, 2024

Abstract Drug‐induced liver injury (DILI) is a severe condition characterized by impaired function and the excessive activation of ferroptosis. Unfortunately, there are limited options currently available for preventing or treating DILI. In this study, MnO 2 nanoflowers (MnO Nfs) with remarkable capabilities mimicking essential antioxidant enzymes, including catalase, superoxide dismutase (SOD), glutathione peroxidase successfully synthesized, SOD dominant enzyme among them density functional theory. Notably, Nfs demonstrate high efficiency in effectively eliminating diverse reactive oxygen species (ROS) such as hydrogen peroxide (H O ), anion (O •− hydroxyl radical (•OH). Through vitro experiments, it demonstrated that significantly enhance recovery intracellular content, acting potent inhibitor ferroptosis even presence activators. Moreover, exhibit excellent accumulation properties, providing robust protection against oxidative damage. Specifically, they attenuate acetaminophen‐induced inhibiting ferritinophagy activating P62‐NRF2‐GPX4 antioxidation signaling pathways. These findings highlight ROS scavenging ability hold great promise an innovative potential clinical therapy DILI other ROS‐related diseases.

Язык: Английский

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Estrogen mitigates ischemia-reperfusion injury by inhibiting cardiomyocyte ferroptosis through the downregulation of PHLDA3 expression

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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The lysosomal-associated membrane protein 2-macroautophagy pathway is involved in the regulatory effects of hippocampal aromatase on Aβ accumulation and AD-like behavior

Life Sciences, Год журнала: 2025, Номер 366-367, С. 123484 - 123484

Опубликована: Фев. 19, 2025

Язык: Английский

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Kunxinning granules alleviate perimenopausal syndrome by supplementing estrogen deficiency

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 26, 2025

Introduction Ovarian function decline results in reduced estrogen levels, leading to endocrine disorders, oxidative stress damage, and excessive activation of inflammatory factors, all which contribute the development premenstrual syndrome (PMS). Kunxinning Granules (KXN) has been clinically approved for PMS treatment, but its bioactive ingredients mechanism action remain unclear. This study aimed investigate active metabolites molecular KXN treating rats, laying a foundation clinical treatment. Methods An ovariectomized (OVX) rat model was established evaluate efficacy PMS. Molecular network (MN) analysis, combined with UPLC/Q-TOF-MS, identified prototype compounds samples constructed chemical classification map based on their structures. A analysis proteomics were conducted predict potential pathways through regulates Quantitative metabolomics assays used confirm these pathways. Additionally, target prediction binding enzyme activity detection elucidated key mechanisms KXN. Results exhibited significant effectiveness supplementing deficiency uterine atrophy OVX model. We 16 absorbed as pharmacological vivo . The steroid hormone biosynthesis pathway, crucial pathway PMS, played role KXN’s effectiveness. improved hormonal metabolic disorders by regulating this pathway. main KXN, including astragaloside IV, icariin baohuoside I increased estradiol levels enhancing CYP19A1, representative Discussion shows that could relieve anxiety, depression, osteoporosis effect is exerted synthesis address deficiency. findings provide valuable insights into underlying support application.

Язык: Английский

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Cutting edge: ferroptosis in metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis and therapy

Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)

Опубликована: Март 25, 2025

Язык: Английский

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PFOS Exposure Impairs Porcine Oocyte Maturation and Embryo Development via Mitochondria-Dependent Ferroptosis

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126185 - 126185

Опубликована: Апрель 1, 2025

Язык: Английский

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Ferroptosis resistance in cancer: recent advances and future perspectives

Biochemical Pharmacology, Год журнала: 2023, Номер 219, С. 115933 - 115933

Опубликована: Ноя. 22, 2023

Язык: Английский

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Mapping the 5-HTergic neural pathways in perimenopausal mice and elucidating the role of oestrogen receptors in 5-HT neurotransmission

Heliyon, Год журнала: 2024, Номер 10(6), С. e27976 - e27976

Опубликована: Март 1, 2024

Perimenopausal syndrome (PMS) encompasses neuropsychiatric symptoms, such as hot flashes and depression, which are associated with alterations in the 5-HTergic neural pathway brain. However, specific changes mechanisms underlying these remain unclear. In this study, ovariectomized mice were used to successfully establish a perimenopause model, expression of 5-HT its receptors (5-HT1AR 5-HT2AR) across 72 brain regions assessed by immunohistochemistry. Although both 5-HT1AR widely expressed throughout brain, only limited number 5-HT2AR. Notably, decreased was observed almost all ovariectomy (OVX) group compared control group; however, altered found within areas related (the preoptic area) or mood disorders amygdala). Additionally, reduced oestrogen receptor (ER)α/β detected cells raphe nucleus (RN), an area known regulate body temperature, some evidence showed that ERα/β positively regulates transcriptional activity enzymes TPH2/MAOA, involved serotonin metabolism during perimenopause. This study revealed neuropathways (5-HT perimenopausal mice, mainly regulation sleep. clarified perimenopause, regulated transcription levels TPH2 MAOA, ultimately led reduction content, providing new target for clinical diagnosis treatment diseases.

Язык: Английский

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17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

Heliyon, Год журнала: 2024, Номер 10(7), С. e29013 - e29013

Опубликована: Апрель 1, 2024

After surgical or natural menopause, women face a high risk of nonalcoholic fatty liver disease (NAFLD), which can be diminished by hormone replacement therapy (HRT). The gut microbiota is subject to modulation various physiological changes and the progression diseases. This microbial ecosystem coexists symbiotically with host, playing pivotal roles in immune maturation, defense mechanisms, metabolic functions essential for nutritional homeostasis. E

Язык: Английский

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Ferroptosis at the nexus of metabolism and metabolic diseases

Theranostics, Год журнала: 2024, Номер 14(15), С. 5826 - 5852

Опубликована: Янв. 1, 2024

Ferroptosis, an iron-dependent form of regulated cell death, is emerging as a crucial regulator human physiology and pathology. Increasing evidence showcases reciprocal relationship between ferroptosis dysregulated metabolism, propagating pathogenic vicious cycle that exacerbates pathology diseases, particularly metabolic disorders. Consequently, there rapidly growing interest in developing ferroptosis-based therapeutics. Therefore, comprehensive understanding the intricate interplay metabolism could provide invaluable resource for mechanistic insight therapeutic development. In this review, we summarize important substances associated pathways initiation progression, outline cascade responses disease development, overview roles mechanisms introduce methods detection, discuss perspectives ferroptosis, which collectively aim to illustrate view basic, translational, clinical science.

Язык: Английский

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