Postharvest Biology and Technology, Год журнала: 2024, Номер 219, С. 113266 - 113266
Опубликована: Окт. 19, 2024
Язык: Английский
Current Opinion in Chemical Biology, Год журнала: 2024, Номер 78, С. 102426 - 102426
Опубликована: Янв. 21, 2024
Язык: Английский
Процитировано
14
Small, Год журнала: 2024, Номер 21(1)
Опубликована: Окт. 23, 2024
Abstract Over the past decade, precision medicine has garnered increasing attention, making significant strides in discovering new therapeutic drugs and mechanisms, resulting notable achievements symptom alleviation, pain reduction, extended survival rates. However, limited target specificity of primary inter‐individual differences have often necessitated high‐dosage strategies, leading to challenges such as restricted deep tissue penetration rates systemic side effects. Material science advancements present a promising avenue for these issues. By leveraging distinct internal features diseased regions application specific external stimuli, responsive materials can be tailored achieve targeted delivery, controllable release, biochemical reactions. This review aims highlight latest stimuli‐responsive their potential medicine. Initially, we introduce disease‐related stimuli capable elucidating reaction principles functional groups. Subsequently, provide detailed analysis representative pre‐clinical across various clinical applications, including enhancements treatment cancers, injury diseases, inflammatory infection high‐throughput microfluidic biosensors. Finally, discuss some challenges, off‐target effects, long‐term impacts nano‐materials, ethical concerns, offer insights into future perspectives materials.
Язык: Английский
Процитировано
10
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 2, 2025
Radiotherapy is crucial in local cancer management and needs advancements. Tumor cells elevate intracellular copper levels to promote growth resist radiation; thus, targeted delivery mitochondria could enhance radiotherapy by inducing cuproptosis tumor cells. In this study, we engineered a multifunctional nanoliposome complex, termed Lipo-Ele@CuO2, which encapsulates both peroxide (CuO2) the chelator elesclomol, can Cu ions mitochondria. The Lipo-Ele@CuO2 complex induces mitochondria-mediated synergistically enhances efficacy of radiotherapy. CuO2 acts as donor exhibits inherent sensitivity acidic environments. Additionally, it depletes glutathione, thereby sensitizing cuproptosis. Leveraging its pH-responsive properties microenvironment, facilitate controlled release efficiently delivering at sites. combined vitro vivo studies demonstrate that Lipo-Ele@CuO2-based therapy significantly improves antitumor excellent safety profiles, effectively boosting effectiveness Furthermore, metabolomic transcriptomic analyses reveal combination precipitates significant alterations energy metabolism, notably repressing genes related iron-sulfur cluster assembly glycolysis, confirming induction This therapeutic strategy provides viable approach for addressing clinical resistance demonstrates translational potential.
Язык: Английский
Процитировано
2
Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Май 15, 2024
Abstract Ferroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in and iron metabolism, contribute to ferroptosis regulation. The gut microbiota not only supplies nutrients energy the host, but also plays crucial role immune modulation balance. In this review, we explore pathways associated with impact on host metabolism. We subsequently summarize recent studies influence regulation by discuss potential mechanisms through which affects ferroptosis. Additionally, conduct bibliometric analysis relationship between context chronic kidney disease. This can provide new insights into current research status future microbiota.
Язык: Английский
Процитировано
8
Redox Biology, Год журнала: 2024, Номер 74, С. 103218 - 103218
Опубликована: Июнь 1, 2024
The ABCC1 gene belongs to the ATP-binding cassette membrane transporter superfamily, which plays a crucial role in efflux of various endogenous and exogenous substances. Mutations can result autosomal dominant hearing loss. However, specific roles auditory function are not fully understood. Through immunofluorescence, we found that was expressed microvascular endothelial cells (ECs) stria vascularis (StV) murine cochlea. Then, an Abcc1 knockout mouse model established by using CRISPR/Cas9 technology elucidate inner ear. ABR threshold did significantly differ between WT Abcc1-/- mice at any age studied. After noise exposure, thresholds were elevated. Interestingly, after 14 days largely returned pre-exposure levels but mice. Our subsequent experiments showed integrity StV compromised number outer hair ribbons decreased cochleae post-exposure. Besides, production ROS accumulation 4-HNE increased. Furthermore, ECs cultured these under glucose oxidase challenge. Notably, 30 U/L (GO) induced severe oxidative stress damage cells. Compared with cells, apoptotic rate elevated In addition, reduced GSH/GSSG ratio GO treatment. Taken together, more susceptible noise-induced loss, possibly because knockdown compromises GSH antioxidant system ECs. N-acetylcysteine (NAC) may protect against
Язык: Английский
Процитировано
8
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Авг. 5, 2024
In recent years, with advancements in medicine, the survival period of patients tumours has significantly increased. The adverse effects tumour treatment on patients, especially cardiac toxicity, have become increasingly prominent. elderly breast cancer, treatment-related cardiovascular toxicity surpassed cancer itself as leading cause death. Moreover, an increasing number novel antitumour drugs, such multitargeted agents, antibody‒drug conjugates (ADCs), and immunotherapies, been applied clinical practice. cardiotoxicity induced by these drugs more pronounced, to a complex diverse mechanism damage. risks unintended are increased high-dose anthracyclines, concurrent radiation, addition traditional risk factors smoking, hypertension, diabetes, hyperlipidaemia, obesity. However, do not fully explain why only subset individuals experience whereas others similar features not. Recent studies indicate that genetics play significant role susceptibility development from therapies. These genes involved drug metabolism, oxidative damage, dysfunction, other processes. emerging evidence suggests epigenetics also plays drug-induced toxicity. We conducted review focusing example help oncologists cardiologists better understand mechanisms genetic this review, we specifically address relationship between alterations including chemotherapy-related changes, targeted therapy-related immune changes. discuss epigenetic hope will improve stratification enable therapeutic interventions mitigate consequences life-saving treatments.
Язык: Английский
Процитировано
7
Animals, Год журнала: 2024, Номер 14(16), С. 2318 - 2318
Опубликована: Авг. 9, 2024
Marine mollusks, including oysters, are highly tolerant to high levels of cadmium (Cd), but the molecular mechanisms underlying their response acute Cd exposure remain unclear. In this study, Pacific oyster Crassostrea gigas was used as a biological model, exposed stress for 96 h. Transcriptomic analyses gills were performed, and metabolomic further validated these results. our total 111 differentially expressed metabolites (DEMs) 2108 genes (DEGs) identified under exposure. Further revealed alterations in key metabolic pathways associated with heavy metal response. triggered physiological responses enhanced oxidative disturbances energy metabolism, changes oysters stress. Moreover, could effectively enhance tolerance detoxification ability through activating ABC transporters, enhancing glutathione metabolism sulfur relay system gill cells, regulating metabolism. This study reveals mechanism explores by using combined metabolomics transcriptome analysis.
Язык: Английский
Процитировано
6
Plants, Год журнала: 2024, Номер 13(7), С. 1003 - 1003
Опубликована: Март 31, 2024
Continuous spring cropping of Qingke (
Язык: Английский
Процитировано
4
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Апрель 29, 2024
Abiotic stresses can increase the total fatty acid (TFA) and astaxanthin accumulation in microalgae. However, it remains unknown whether a unified signal transduction mechanism exists under different stresses. This study explored link between nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) of acids Chromochloris zofingiensis three abiotic Results showed significant increases acid, astaxanthin, ROS levels nitrogen deficiency, phosphorus high-salinity stress. The introduction NADPH oxidase inhibitor diphenyleneiodonium (DPI) decreased content these components. underscores pivotal role Analysis transcriptomes across conditions following DPI addition revealed 1,445 shared differentially expressed genes (DEGs). Enrichment analysis that biotin, betalain, thiamine, glucosinolate may be important stress responses. heatmap demonstrated notably suppressed gene expression carotenoid biosynthesis pathways. Our findings underscore
Язык: Английский
Процитировано
4
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(9), С. 5595 - 5608
Опубликована: Авг. 15, 2024
Analysis of biomarkers in living cells is crucial for deciphering the dynamics as well precise diagnosis diseases. DNA biosensors employ sequences probes to offer insights into cells, and drive progress disease drug development. In this review, we present recent advances detecting cells. The basic structural components signal output method are presented. strategies crossing cell membrane also described, including coincubation, nanocarriers, nanoelectroporation techniques. Based on biomarker categorization, detail applications small molecules, RNAs, proteins, integrated targets Furthermore, future development directions summarized encourage further research growing field.
Язык: Английский
Процитировано
3