Hydrogen nanobubbles enhancing antioxidant activity of glutathione peroxidase: Superiority at the nanoscale over molecular scale

Nano Today, Год журнала: 2024, Номер 59, С. 102510 - 102510

Опубликована: Сен. 26, 2024

Язык: Английский

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Evanescent hormesis effect induced by environmentally related PFOS to marine Chlorella sp

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136115 - 136115

Опубликована: Окт. 9, 2024

Язык: Английский

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Acute exposure to nitrogen mustard induces rapid nuclear component regulation and delayed stress to exogenous stimuli

International Immunopharmacology, Год журнала: 2025, Номер 147, С. 113976 - 113976

Опубликована: Янв. 8, 2025

Язык: Английский

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The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options

Frontiers in Molecular Biosciences, Год журнала: 2025, Номер 12

Опубликована: Фев. 4, 2025

Intracerebral hemorrhage (ICH) is a non traumatic that occurs in certain part of the brain. It usually leads to brain cell damage. According large number experimental research, oxidative stress an important pathophysiological processes cerebral hemorrhage. In this paper, we aim determine how changes biomarkers indicate damage degree hemorrhage, and explore summarize potential treatments or interventions. We found patients with are characterized by increased levels markers, such as total malondialdehyde (MDA), F2 isoprostaglandin, hydroxynonenal, myeloperoxidase protein hydroxyl. Therefore, caused ICH on these markers can be used evaluate diagnose ICH, predict its prognosis, guide preventive treatment turn antioxidant based new alternative.

Язык: Английский

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Soybean meal-refined treatment mitigated high soybean meal diet-induced oxidative damage in the gut of crayfish via microbial metabolic function remodeling

Aquaculture, Год журнала: 2025, Номер unknown, С. 742286 - 742286

Опубликована: Фев. 1, 2025

Язык: Английский

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Gliadin-Rich Diet Worsens Immune and Redox Impairments in Prematurely Aging Mice

Cells, Год журнала: 2025, Номер 14(4), С. 279 - 279

Опубликована: Фев. 14, 2025

Gliadin is one of the most important fractions gluten, a glycoprotein closely linked to development negative effects on physiological functions and gastrointestinal diseases, such as celiac disease (CD). Research suggests that inadequate stress responses anxiety states may trigger or at least contribute these pathological conditions. Peritoneal leukocytes from Prematurely Aging Mice (PAM), which are chronologically adult mice with compromised anxiety, exhibit functional changes when exposed in vitro gliadin peptides, resembling some immune alterations found also CD patients. This observation prompted us investigate gliadin-rich diet function redox state PAM. In this study, female PAM were fed either gluten-enriched (PAMD, 120 g/kg) standard (PAMC) for four weeks. Immune parameters peritoneal, splenic, thymic (phagocytosis, chemotaxis, Natural Killer activity, lymphoproliferation) markers (glutathione reductase, glutathione peroxidase, reduced/oxidized glutathione, xanthine oxidase lipid peroxidation) evaluated. The results showed PAMD exhibited more impaired function, lower antioxidant enzyme activities, reduced concentrations, well higher oxidized increased activity compared PAMC. These findings suggest worsens impairments PAM, previously described CD, indicating potential animal studying gluten-induced dysregulation.

Язык: Английский

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Revealing the Transcriptional and Metabolic Characteristics of Sebocytes Based on the Donkey Cell Transcriptome Atlas

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Abstract Worldwide, donkeys ( Equus asinus ) are valued for their meat and milk, in China also the medical value of skin. Physiological characteristics key to donkey's adaptability, including digestive, respiratory, reproductive systems, which enable them survive work a variety environments. However, understanding donkey physiological at cellular level remains poor. Thus, single‐cell transcriptome sequencing is used construct detailed transcriptional atlas based on 20 tissues from Dezhou (in total 84 cell types 275 050 high quality cells) perform an in‐depth investigation molecular physiology. Cross‐species cross‐tissue comparative analyses reveal SOX10 be evolutionally conserved regulon oligodendrocytes illuminate distinctive patterns sebocytes. Moreover, through multispecies skin metabolomics, highly abundant, species‐specific metabolites identified, such as arachidonic acid gamma‐glutamylcysteine, pivotal role sebocytes metabolism highlighted. In summary, this offers new insights into unique metabolic provides valuable resource conservation germplasm advancement selective breeding programs.

Язык: Английский

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Anthracycline-induced cardiotoxicity: emerging mechanisms and therapies

Medicine Plus, Год журнала: 2025, Номер unknown, С. 100074 - 100074

Опубликована: Фев. 1, 2025

Язык: Английский

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Perfluorooctane sulfonate mediates GSH degradation leading to oral keratinocytes ferroptosis and mucositis through activation of the ER stress-ATF4-CHAC1 axis

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117964 - 117964

Опубликована: Март 1, 2025

Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant that induces inflammatory response and oxidative stress in oral mucosa. Ferroptosis, form of cell death characterized by iron-dependent lipid peroxidation (the degradation lipids), was believed to play crucial role pathogenesis mucositis; however, the involvement PFOS-induced ferroptosis remained unclear. Our findings demonstrated PFOS inhibited proliferation induced pro-apoptotic effects cells, with most pronounced observed human keratinocytes (HOK). significantly increased reactive oxygen species (ROS) peroxidation, depleted glutathione (GSH) HOK cells. Notably, decreased peroxidase 4 (GPX4) expression elevated Fe2 + levels, suggesting potential induction ferroptosis. Ferroptosis inhibitors mitigated GSH depletion, subsequently enhancing viability. Mechanistically, endoplasmic reticulum (ER) contributed nuclear translocation (from cytoplasm into nucleus) activating transcription factor (ATF4) up-regulated its downstream target gene Chac1. Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) catalyzed conversion cysteinylglycine 5-oxoproline, resulting depletion-a critical Knocking down CHAC1 attenuated Tauroursodeoxycholic acid (TUDCA), classical ER inhibitor, mucositis inhibiting ATF4/CHAC1 pathway activation. These elucidated toxicological mechanisms proposed therapeutic strategies counteract exposure mucositis.

Язык: Английский

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Radiation-triggerable bioreactors enable bioenergetic reprograming of cancer stem cell plasticity via targeted arginine metabolism disruption for augmented radio-immunotherapy

Biomaterials, Год журнала: 2025, Номер 322, С. 123391 - 123391

Опубликована: Май 5, 2025

Язык: Английский

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