Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3521 - 3521

Опубликована: Март 20, 2024

The phrase “Let food be thy medicine…” means that can a form of medicine and food; in other words, the diet we eat have significant impact on our health well-being. Today, this is gaining prominence as more scientific evidence suggests one’s help prevent treat disease. A rich fruits, vegetables, whole grains, lean protein reduce risk heart disease, cancer, diabetes, problems and, hand, processed foods, added sugars, saturated fats increase same diseases. Electrophilic compounds health, they are molecules covalently modify cysteine residues present thiol-rich Keap1 protein. These bind to activate NRF2, which promotes its translocation nucleus binding DNA ARE region, triggering antioxidant response protecting against oxidative stress. include polyphenols flavonoids nucleophilic but converted electrophilic quinones by metabolic enzymes such polyphenol oxidases (PPOs) sulfur foods Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) garlic. This review summarizes current knowledge subject.

Язык: Английский

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Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components

Mechanisms of Ageing and Development, Год журнала: 2024, Номер 220, С. 111960 - 111960

Опубликована: Июль 5, 2024

Язык: Английский

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The effects of SOY extract nutraceuticals on postmenopausal women’s health: A randomized, double-blind, placebo-controlled trial

Journal of Functional Foods, Год журнала: 2024, Номер 113, С. 106055 - 106055

Опубликована: Янв. 31, 2024

Postmenopausal women experience physiological changes due to estrogen decline, affecting skin aging, bone health, and quality of life. The present study investigated the effects soy extract nutraceutical (SOY) product on facial turnover markers, menopausal symptoms, life in postmenopausal by means a randomized controlled trial. lipids profiles, glucose levels, insulin parameters were also explored. Participants received either SOY (n = 50) or placebo for 12 weeks. results showed significant improvements wrinkle markers group. While no major differences observed symptoms between groups, group exhibited reduction total cholesterol levels. This underscores product's potential addressing management women.

Язык: Английский

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Enhancing colonic health with encapsulated grape seed anthocyanins: Oral capsule for Colon-targeted delivery

Food Chemistry, Год журнала: 2024, Номер 469, С. 142544 - 142544

Опубликована: Дек. 18, 2024

Язык: Английский

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Chemical profile changes in Peanut seeds infected with aspergillus flavus via widely targeted metabolomics

Food Chemistry, Год журнала: 2025, Номер unknown, С. 142750 - 142750

Опубликована: Янв. 1, 2025

Язык: Английский

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Strategies for Decontamination and Alleviation of Mycotoxins for Sustainable Poultry Farming – A Review

Annals of Animal Science, Год журнала: 2025, Номер 25(1), С. 139 - 157

Опубликована: Янв. 1, 2025

Abstract Mycotoxins including aflatoxins (AF), zearalenone (ZEN), ochratoxin A (OTA), fumonisins (FUM), trichothecenes (TCN), deoxynivalenol (DON), and T-2 toxin had negative influences on poultry productivity causing a depression in performance, product quality, antioxidative properties, immunity, health status, economic value sustainability of production. The liver kidney are the organs most affected by dysfunction genetic damage (carcinogenicity, mutagenicity, teratogenicity). Chemical physical approaches, washing extracting solvents, heat inactivation, irradiation, chemical agents, used to detoxify mycotoxins feedstuff. Also, dietary addition adsorbents (zeolites, bentonites, hydrated sodium calcium aluminosilicate, glucomannan, etc.) is strategy extensively Additionally, several feed additives, microorganisms, phytogenic natural anti-oxidants, can reduce impacts achieve promising results industry. However, efficacies these various strategies different, showing distinct variations, some limited effectiveness. Moreover, minimum time required induce complete recovery from lacking literature, as four weeks after removal, there still adverse effects performance physiological traits. This review focuses impact different for eliminating or mitigating their immunological traits means. In addition, mycotoxicosis effect molecular pathways prevention alleviation additives concerning have been evaluated.

Язык: Английский

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Optimization of Ultrasonic-Enzyme Synergistic Extraction of Proanthocyanidins from Jujube: Purification, Characterization, and Bioactivity Study

Molecules, Год журнала: 2025, Номер 30(3), С. 619 - 619

Опубликована: Янв. 31, 2025

Proanthocyanidins have received extensive attention due to their high functional value, but sources are limited. Therefore, this experiment studied the preparation, biological activities, and characterization of proanthocyanidins from Chinese jujube (Ziziphus jujuba Mill. cv. Muzao) at different periods, aiming explore a new source enhance utilization value. Through ultrasonic-assisted enzymatic extraction, optimal extraction conditions for PC Muzao were determined, yielding proanthocyanidin content 2.01%. Purification using AB-8 macroporous resin increased by 11 times. The bioactivity results indicated that demonstrated significant in vitro antioxidant activity (scavenging rate ≥ 83.4%) blood glucose-lowering (inhibition 84.7%). Both activities decreased with maturity, while degree polymerization also exhibited positive effect. Mass spectrometry identified total 102 compounds, cyanidin-based compounds being most abundant, comprising 28 species. comprehensive research indicate oligomeric extracted, purified, isolated during young fruit stage exhibit diverse abundant content. They can be utilized purification proanthocyanidins, offering reference expansion natural development foods.

Язык: Английский

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The application of procyanidins in diabetes and its complications: a review of preclinical studies

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 10, 2025

Diabetes mellitus (DM) and its various complications, including diabetic nephropathy, retinopathy, neuropathy, cardiovascular disease, ulcers, pose significant challenges to global health. This review investigates the potential of procyanidins (PCs), a natural polyphenolic compound, in preventing managing diabetes complications. PCs, recognized for their strong antioxidant, anti-inflammatory, anti-hyperglycemic properties, play crucial role reducing oxidative stress enhancing endothelial function, which are essential elucidates molecular mechanisms by PCs improve insulin sensitivity health, thereby providing protection against complications diabetes. The comprehensive analysis underscores promising therapeutic care, indicating need further clinical studies confirm leverage management strategies.

Язык: Английский

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A Combination of 5-(3′,4′-Dihydroxyphenyl)-γ-Valerolactone and Curcumin Synergistically Reduces Neuroinflammation in Cortical Microglia by Targeting the NLRP3 Inflammasome and the NOX2/Nrf2 Signaling Pathway

Nutrients, Год журнала: 2025, Номер 17(8), С. 1316 - 1316

Опубликована: Апрель 10, 2025

Background/Objectives: 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone (γ-VL), recently identified as a predominant microbial metabolite derived from proanthocyanidins, offers benefits such reducing inflammation, oxidative stress, and supporting brain health. Its effects on neuroinflammation microglial activation remain largely unexplored. Curcumin, bioactive component isolated Curcuma longa L., is well known for its ability to reduce pro-inflammatory mediator production release. While the individual of γ-VL curcumin are documented, their potential combined This research sought investigate possible synergistic in activation. Methods: Primary rat cortical microglia were pre-treated with curcumin, alone or combination, before stimulation LPS. An MTT assay was used evaluate cell viability, while mediators assessed by real-time PCR ELISA. Nitric oxide evaluated Griess assay. SynergyFinder Plus software analyzed effects. Results: The combination low micromolar concentrations synergistically reduced LPS-induced Specifically, exhibited significantly greater inhibit release factors (such IL-1β, TNF-α, NO) compared each compound individually. Mechanistically, anti-inflammatory activity attributed downregulation NLRP3 expression, reduction linked modulation NOX2/Nrf2 signaling pathway. Conclusions: produces targeting key inflammatory pathways, indicating utility treatment strategy neurodegenerative diseases involving

Язык: Английский

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The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals

Open Medicine, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

Polyphenols are a group of compounds identified as secondary metabolites plants, with 8,000 types to date. Previous research findings have indicated the potential anti-inflammatory properties polyphenols, studies suggesting reduction in disease risk and therapeutic benefits observed various diseases, including diabesity, neurodegeneration, cancer, cardiovascular disease. The objective this study was comprehensively analyze polyphenol composition extracts Greek mountain tea (GMT) wheat germ (WG) investigate their effects on microcirculation eicosanoid metabolism. spermidine GMT WGE analyzed using LC-HRMS. Hemodynamic impact or WG rat cremasteric arteriole blood flow measured after compound administration laser Doppler meter. Lipidomic analysis urine co-administration by LC-HRMS mass spectrometry. This shows that contains large amount expecially ferulic acid petunidin. In contrast, extract we found minimal content. Subsequent rats, significant increase observed, while exhibited change. Following single oral mice, 24 h for eicosanoids. A decrease pro-inflammatory eicosanoids substantial were treatment compared control group. Given established role intake enhancing vascular endothelial function increasing peripheral flow, suggest is consequence polyphenols GMT. enhancement balance more pronounced group, effect may be attributable components other than present these fractions.

Язык: Английский

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