Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Авг. 28, 2024
Non-small
cell
lung
cancer
(NSCLC),
being
the
most
prevalent
and
lethal
malignancy
affecting
lungs,
poses
a
significant
threat
to
human
health.
This
research
aims
at
illustrating
precise
role
related
mechanisms
of
silent
information
regulator
type-1
(SIRT1)
in
NSCLC
progression.
The
expression
pattern
SIRT1
lines
was
examined
using
quantitative
real-time
polymerase
chain
reaction
western
blotting.
Functional
assays
validated
biological
capabilities
on
malignant
phenotypes,
its
impact
tumorigenicity
further
evaluated
vivo.
In
addition,
FOXO1
inhibitor
AS1842856
applied
verify
FOXO
pathway
vitro.
prominently
elevated
lines.
depletion
retarded
proliferation,
migration
invasion,
while
enhancing
apoptosis
cells.
Furthermore,
silencing
restricted
tumorigenesis
Additionally,
treatment
ameliorated
inhibitory
effect
deficiency
phenotypes
deletion
exerted
an
anti-oncogenic
via
activation
FOXO1.
Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 298 - 298
Опубликована: Фев. 28, 2024
Ferroptosis
is
a
type
of
programmed
cell
death
that
differs
from
apoptosis,
autophagy,
and
necrosis
related
to
several
physio-pathological
processes,
including
tumorigenesis,
neurodegeneration,
senescence,
blood
diseases,
kidney
disorders,
ischemia–reperfusion
injuries.
linked
iron
accumulation,
eliciting
dysfunction
antioxidant
systems,
which
favor
the
production
lipid
peroxides,
membrane
damage,
ultimately,
death.
Thus,
signaling
pathways
evoking
ferroptosis
are
strongly
associated
with
those
protecting
cells
against
excess
and/or
lipid-derived
ROS.
Here,
we
discuss
interaction
between
metabolic
particular
focus
on
transcription
factors
implicated
in
regulation
ferroptosis,
either
as
triggers
peroxidation
or
defense
pathways.
Abstract
Disulfidptosis
is
a
novel
form
of
cell
death
that
distinguishable
from
established
programmed
pathways
such
as
apoptosis,
pyroptosis,
autophagy,
ferroptosis,
and
oxeiptosis.
This
process
characterized
by
the
rapid
depletion
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
in
cells
high
expression
solute
carrier
family
7
member
11
(SLC7A11)
during
glucose
starvation,
resulting
abnormal
cystine
accumulation,
which
subsequently
induces
andabnormal
disulfide
bond
formation
actin
cytoskeleton
proteins,
culminating
network
collapse
disulfidptosis.
review
aimed
to
summarize
underlying
mechanisms,
influencing
factors,
comparisons
with
traditional
pathways,
associations
related
diseases,
application
prospects,
future
research
directions
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 5, 2025
Background
Personalized
precision
medicine
(PPPM)
in
cancer
immunology
and
oncology
is
a
rapidly
advancing
field
with
significant
potential.
Gliomas,
known
for
their
poor
prognosis,
rank
among
the
most
lethal
brain
tumors.
Despite
advancements,
there
remains
critical
need
precise,
individualized
treatment
strategies.
Methods
We
conducted
comprehensive
analysis
of
RNA-seq
microarray
data
from
TCGA
GEO
databases,
supplemented
by
single-cell
RNA
sequencing
(scRNA-seq)
glioma
patients.
By
integrating
foundational
experiments,
we
investigated
molecular
variations
cellular
interactions
within
neural
cell
subpopulations
during
tumor
progression.
Results
Our
revealed
distinct
gene
expression
patterns
across
subpopulations.
Notably,
differentiation
trajectory
identified
NUSAP1
as
key
marker
terminal
subpopulation.
found
that
elevated
correlated
prompting
further
investigation
its
functional
role
through
both
animal
studies.
Conclusions
NUSAP1-based
risk
models
hold
potential
predictive
therapeutic
tools
personalized
treatment.
In-depth
exploration
NUSAP1’s
mechanisms
glioblastoma
could
enhance
our
understanding
response
to
immunotherapy,
suggesting
targeting
may
offer
benefits
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Март 5, 2025
Ferroptosis
is
a
novel
form
of
cell
death
that
uniquely
requires
iron
and
characterized
by
accumulation,
the
generation
free
radicals
leading
to
oxidative
stress,
formation
lipid
peroxides,
which
distinguish
it
from
other
forms
death.
The
regulation
ferroptosis
extremely
complex
closely
associated
with
spectrum
diseases.
Sirtuin
1
(SIRT1),
NAD
+
-dependent
histone
deacetylase,
has
emerged
as
pivotal
epigenetic
regulator
potential
regulate
through
wide
array
genes
intricately
metabolism,
homeostasis,
glutathione
biosynthesis,
redox
homeostasis.
This
review
provides
comprehensive
overview
specific
mechanisms
SIRT1
regulates
explores
its
therapeutic
value
in
context
multiple
disease
pathologies,
highlighting
significance
SIRT1-mediated
treatment
strategies.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 11, 2025
Background
Recently,
many
studies
have
focused
on
the
relationship
between
senescence
and
immunotherapy
in
cancer
treatment.
However,
relatively
few
examined
intrinsic
links
three.
Whether
these
can
act
synergistically
fight
against
specific
them
are
still
unclear.
Methods
We
extracted,
quantified,
visualized
data
from
literature
(n
=
2396)
for
period
2004-2023
after
rigorous
quality
control
using
citespace,
GraphPad
Prism,
R
software
package,
VOSviewer.
Results
Linear
fit
analyses
were
generated
to
predict
number
of
annual
publications
citations
as
a
function
top-performing
authors,
journals,
countries,
affiliations
academically
over
past
two
decades
such
Weiwei,
Aging-us,
China,
UT
MD
Anderson
Cancer
Center.
Vosviewer-based
hierarchical
clustering
further
categorized
study
characteristics
into
six
clusters,
including
major
clusters
research,
immunosenescence-related
research
factors,
timeline
distributions
suggesting
that
cellular
tumor
progression
is
new
cluster
warrants
exploration
development.
Study
characterization
bursts
linear
regression
confirmed
findings
revealed
other
important
results,
aging
(a
1.964,
R²
0.6803)
16.38,
0.8812).
Furthermore,
gene
frequency
analysis
this
most
abundant
gene,
APOE
,
SIRT1-7
proteins.
Conclusion
The
combination
therapies
with
immunotherapies
currently
its
preliminary
stages.
Although
has
greatest
impact
ICB
therapies,
mechanistic
investigations,
drug
development
sirt1-7
(Sirtuins
family)
targets
may
be
key
combining
treatment
tumors.
