Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis

Trends in Biochemical Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Macrophage pyroptosis and its crucial role in ALI/ARDS

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 14, 2025

Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to injury. However, the pathogenesis of ALI/ARDS remains complex issue. In recent years, role macrophage pyroptosis in injury has garnered extensive attention worldwide. This paper reviews mechanism pyroptosis, discusses its ALI/ARDS, introduces several drugs intervening measures that can regulate influence progression ALI/ARDS. By doing so, we aim enhance understanding provide novel insights for treatment.

Язык: Английский

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Glutathione reductase underlies the stability of mutant p53 by antagonizing protein glutathionylation

Redox Biology, Год журнала: 2025, Номер unknown, С. 103522 - 103522

Опубликована: Янв. 1, 2025

Язык: Английский

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Corilagin alleviates ferroptosis in diabetic retinopathy by activating the Nrf2 signaling pathway

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117409 - 117409

Опубликована: Сен. 8, 2024

Язык: Английский

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Wuwei Shaji powder alleviates OVA-induced allergic asthma by protecting bronchial epithelial cells from ferroptosis via the S-sulfhydration of Keap1

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119649 - 119649

Опубликована: Апрель 1, 2025

Язык: Английский

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A Case Study on Complete Pathological Response in Advanced Rectal Cancer Patient with Oxaliplatin-based Chemotherapy without Cumulative Neurotoxicity

Journal of Gastrointestinal Cancer, Год журнала: 2025, Номер 56(1)

Опубликована: Апрель 16, 2025

Язык: Английский

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Mechanism of Protective Effect of Mongolia Medicine Nagab-9 on LPS-Induced Acute Lung Injury Based on an Integrated Network Pharmacology and Experimental Verification

Dose-Response, Год журнала: 2025, Номер 23(2)

Опубликована: Апрель 1, 2025

Objectives To investigate the potential mechanisms of Nagab-9 in alleviating acute lung injury (ALI) by integrating network pharmacology analysis with vivo and vitro validation experiments. Methods Active compounds were identified using TCMSP ETCM databases. ALI-related targets collected from relevant disease databases, an intersection these was used to construct a protein-protein interaction (PPI) identify core targets. Functional through Gene Ontology (GO) KEGG pathway enrichment performed. The key intervention ALI further validated LPS-induced mouse models alveolar epithelial cell models. Results A total 25 active components Nagab-9. PPI highlighted targets, GO analyses significant pathways involved. Six selected based on topological parameters “compound-target-pathway-disease” network. In vivo, shown alleviate ALI-induced damage, inhibit inflammatory infiltration, modulate factors downregulating Ly6G, Cit-H3, phosphorylated proteins SRC, ERK1/2, STAT3 tissue. experiments demonstrated that effectively inhibits responses, protecting tissue suppressing neutrophil infiltration NET formation, likely SRC/ERK1/2/STAT3 pathway. Conclusion exerts protective effect against modulating responses reducing primarily via signaling This study supports as promising therapeutic agent for intervention.

Язык: Английский

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RSL3 sensitizes glioma cells to ionizing radiation by suppressing TGM2-dependent DNA damage repair and epithelial-mesenchymal transition

Redox Biology, Год журнала: 2024, Номер 78, С. 103438 - 103438

Опубликована: Ноя. 19, 2024

Язык: Английский

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Glutathione S-transferase: A keystone in Parkinson's disease pathogenesis and therapy

Molecular and Cellular Neuroscience, Год журнала: 2024, Номер unknown, С. 103981 - 103981

Опубликована: Дек. 1, 2024

Язык: Английский

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Identification and molecular mechanism of novel antioxidant peptides from tiger nut (Cyperus esculentus L.)

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105738 - 105738

Опубликована: Дек. 1, 2024

Язык: Английский

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