Association of systemic immune-inflammatory index with in-stent restenosis in patients with and without diabetes mellitus
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 20, 2025
Background
Systemic
inflammation
plays
a
vital
role
in
the
pathogenesis
and
prognosis
of
cardiovascular
disease
(CAD).
The
systemic
immune-inflammation
index
(SII)
has
been
developed
as
cost-effective
practical
predictor
for
CAD
outcomes.
This
study
aimed
to
determine
association
between
SII
risk
ISR
among
ACS
patients
with
without
diabetes
mellitus
(DM).
Methods
In
this
retrospective
cohort
study,
total
1,652
who
underwent
percutaneous
coronary
intervention
(PCI)
from
February
2015
December
2020
were
finally
enrolled
after
follow-up
angiography.
was
calculated
based
on
neutrophil,
platelet
lymphocyte
counts.
Multivariable
logistic
regression
models
employed
assess
associations
prevalence.
Additionally,
interaction
test
subgroup
analysis
performed
evaluate
robustness
our
findings.
Furthermore,
restricted
cubic
splines
applied
visualize
relationship
ISR.
Employing
Spearman's
rank
correlation
investigate
levels
time
occurrence.
Results
whole
128
(7.7%)
participants
angiographic
evidence
results
demonstrated
that
level
significantly
increased
compared
those
non-ISR,
these
findings
similar
DM.
After
adjusting
confounders,
multivariate
revealed
higher
had
diabetics
(all
P
<
0.05),
significant
observed
more
severe
(triple-coronary
artery
lesions).
RCS
reveals
there
is
J-shaped
nonlinear
entire
(
overall
<0.001,
nonlinearity
=
0.0058,
respectively).
Moreover,
threshold
effect
can
be
cohort,
an
inflection
point
at
log2-SII
value
9.276
(SII
620).
Specifically,
linearly
associated
0.0007
0.4316,
respectively),
indicating
stronger
diabetic
than
diabetes.
elevated
are
related
earlier
onset
r
−0.272,
0.049).
Conclusion
Our
suggests
may
affordable
convenient
marker
could
predict
patients.
emphasized
high
independent
helpful
patients'
stratification,
especially
comorbid
Язык: Английский
Metabolic Crosstalk between Platelets and Cancer: Mechanisms, Functions, and Therapeutic Potential
Seminars in Cancer Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Impairment of platelet mitochondrial respiration in patients with chronic kidney disease with and without diabetes
Glăvan Mihaela-Roxana,
Stanciu-Lelcu Theia,
Aburel Oana-Maria
и другие.
Molecular and Cellular Biochemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 12, 2025
Chronic
kidney
disease
(CKD)
and
diabetic
(DKD)
are
major
public
health
problems,
their
burden
is
growing
relentlessly
with
the
aging
of
global
population.
Their
early
recognition
now
a
priority,
there
an
unmet
need
for
identification
specific
biomarkers
in
minimally
invasive
or
non-invasive
samples.
Mitochondrial
dysfunction
plays
pivotal
role
development
progression
both
CKD
DKD
circulating
platelets
have
emerged
as
ideal
candidate
assessment
respiratory
function.
The
present
study
assessed
mitochondrial
respiration
isolated
from
peripheral
blood
patients
compared
to
healthy
controls.
included
total
number
89
subjects,
follows:
30
divided
into
three
subgroups
based
on
urinary
albumin-to-creatinine
ratio
(uACR):
20
normoalbuminuric,
10
microalbuminuric,
macroalbuminuric,
29
(positive
controls)
individuals
(negative
controls).
Platelets
were
by
differential
centrifugations
high-resolution
respirometry
protocol
was
adapted
assess
dependent
complex
I
(CI)
II
(CII).
A
significant
reduction
CI-supported
active
found
normoalbuminuric
further
decreased
microalbuminuric
subgroup.
Both
CI
CII-dependent
coupled
maximal
uncoupled
significantly
reduced
macroalbuminuric
In
conclusion,
impairment
evident
stages
DKD.
Moreover,
platelet
more
severely
impaired
those
CKD.
Further,
extensive
follow-up
studies
warranted
determine
whether
could
serve
biomarker
and/or
prognostic
tool
Язык: Английский
Platelets and diseases: signal transduction and advances in targeted therapy
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Май 15, 2025
Abstract
Platelets
are
essential
anucleate
blood
cells
that
play
pivotal
roles
in
hemostasis,
tissue
repair,
and
immune
modulation.
Originating
from
megakaryocytes
the
bone
marrow,
platelets
small
size
but
possess
a
highly
specialized
structure
enables
them
to
execute
wide
range
of
physiological
functions.
The
platelet
cytoplasm
is
enriched
with
functional
proteins,
organelles,
granules
facilitate
their
activation
participation
repair
processes.
Platelet
membranes
densely
populated
variety
receptors,
which,
upon
activation,
initiate
complex
intracellular
signaling
cascades.
These
pathways
govern
aggregation,
release
bioactive
molecules,
including
growth
factors,
cytokines,
chemokines.
Through
these
mechanisms,
integral
critical
processes
such
as
thrombosis,
wound
healing,
surveillance.
However,
dysregulated
function
can
contribute
pathological
conditions,
cancer
metastasis,
atherosclerosis,
chronic
inflammation.
Due
central
involvement
both
normal
physiology
disease,
have
become
prominent
targets
for
therapeutic
intervention.
Current
treatments
primarily
aim
modulate
prevent
thrombosis
cardiovascular
diseases
or
reduce
excessive
aggregation
other
conditions.
Antiplatelet
therapies
widely
employed
clinical
practice
mitigate
clot
formation
high-risk
patients.
As
biology
continues
evolve,
emerging
strategies
focus
on
refining
modulation
enhance
outcomes
complications
associated
dysfunction.
This
review
explores
structure,
pathways,
biological
functions,
potential
platelets,
highlighting
contexts.
Язык: Английский