Mitochondrial ROS-associated integrated stress response is involved in arsenic-induced blood-testis barrier disruption and protective effect of melatonin

Environment International, Год журнала: 2025, Номер 197, С. 109346 - 109346

Опубликована: Фев. 23, 2025

Arsenic (As) is an environmental metalloid. Previous studies have demonstrated that As exposure resulted in decline of sperm quality. This study aimed to investigate the impact on blood-testis barrier (BTB) a mouse model. Four-week-old male mice were exposed NaAsO2 (1 or 15 mg/L) for 6 weeks. Our results found disrupted BTB and reduced counts adult mice. activated integrated stress response (ISR) downregulated junction protein testes Sertoli cells. Ribosome profiling sequencing (Ribo-seq) Ribosome-nascent chain complex-bound mRNA qPCR (RNC-qPCR) showed translational efficiency N-cadherin ZO-1, two key proteins, was NaAsO2-treated Mechanistically, SIRT3 via proteasomal degradation, thereby resulting mitochondrial dysfunction excess ROS (mtROS) generation Melatonin alleviated NaAsO2-induced mtROS upregulation reducing SOD2 acetylation Moreover, melatonin antagonized ISR, proteins downregulation function impairment Accordingly, attenuated NaAsO2-evoked disruption count reduction These suggest dysfunction-associated inhibition involved As-mediated quality decline.

Язык: Английский

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Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells

Redox Biology, Год журнала: 2024, Номер 76, С. 103312 - 103312

Опубликована: Авг. 17, 2024

Strong evidence indicates that environmental stressors are the risk factors for male testosterone deficiency (TD). However, mechanisms of stress-induced TD remain unclear. Based on our all-cause reproductive cohort, we found serum ferrous iron (Fe

Язык: Английский

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Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 15, 2025

Acute kidney injury (AKI) has become a disease of global concern due to its high morbidity and mortality. This highlighted the need for renoprotective agents. Astragaloside IV (AS-IV) is saponin isolated from Astragalus membranaceus with good antioxidant, anti-inflammatory anti-tumor properties. In this study, HK2 cells rat model were utilized explore protective effect AS-IV against cadmium chloride-induced oxidative stress-induced apoptosis. CdCl2-induced apoptosis, ROS production, mitochondrial membrane potential alterations significantly inhibited in -treated cells. Expression mitochondria-associated apoptotic proteins Cleaved-Caspase3, Cleaved-Caspase9, Cleaved-PARP was reduced after intervention. addition, Rat weight loss also alleviated symptoms nephrotoxicity injury. Further experiments showed that suppresses heavy metal Cd-induced mitochondria-mediated apoptosis by regulating Nrf2/HO-1 pathway. conclusion, could protect metal-induced toxicity be used as nephroprotective agent.

Язык: Английский

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Association of cadmium and lead exposure with mortality in cancer survivors: A prospective cohort study

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117960 - 117960

Опубликована: Март 1, 2025

Lead and cadmium are well-documented for their carcinogenic properties potential to induce cellular malignancy. Nevertheless, there is a paucity of research examining the correlation between blood lead levels prognostic outcomes cancer survivors. This study aims investigate relationship concentrations these heavy metals both overall site-specific mortality risks among We identified rates specific causes death survivors by using National Health Nutrition Examination Survey data. To assess outcomes, we employed multivariable Cox regression analyses, generating hazard ratios (HR) 95 % confidence intervals (CI). used Kaplan-Meier survival curves restricted cubic spline models further examine associations. conducted subgroup analyses observe associated with high across various tumor categories. revealed significant positive whole concentration all-cause in survivors, yielding ratio 1.73 (95 CI: 1.39-2.16). Elevated were significantly linked increased cancer-specific mortality, an HR 2.72 1.73-4.26). A notable association was found (HR = 1.83, 1.13-2.97). Subgroup indicated that elevated correlated risk patients skin soft tissue cancers, whereas greater reproductive system cancers. Additionally, related marked increase lung mediastinal malignancies. In conclusion, our indicates

Язык: Английский

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Brazilin alleviates acute lung injury via inhibition of ferroptosis through the SIRT3/GPX4 pathway

APOPTOSIS, Год журнала: 2024, Номер unknown

Опубликована: Дек. 25, 2024

Язык: Английский

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Puerarin Modulates the P62-Keap1-NRF2 Pathway and Enhances CA7 Function to Inhibit Ferroptosis in Ethanol-Induced Gastric Mucosal Injury

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106127 - 106127

Опубликована: Фев. 1, 2025

Язык: Английский

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Based on the Sam50-MICOS-ATAD3-mtDNA axis: Exploring oligomeric proanthocyanidins to alleviate molybdenum and cadmium co-induced liver inflammation in sheep

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141035 - 141035

Опубликована: Фев. 1, 2025

Язык: Английский

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Cadmium disrupted homeostasis of proximal renal tubular cells via targeting ATF4-CHOP complex into the nucleus

Poultry Science, Год журнала: 2025, Номер unknown, С. 105059 - 105059

Опубликована: Март 1, 2025

Язык: Английский

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A peptide fluorescent probe based on Aggregation-Induced Emission for monitoring cadmium ions in complex biological systems

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 116286 - 116286

Опубликована: Март 1, 2025

Язык: Английский

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Polystyrene nanoplastics exposure trigger cognitive impairment mitigated by Luteolin modulated glucose-6-phosphate dehydrogenase/glutathione-dependent pathway

Journal of Hazardous Materials, Год журнала: 2025, Номер 493, С. 138404 - 138404

Опубликована: Апрель 24, 2025

Язык: Английский

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