Elevated Body Mass Index Aggravates Histopathological Changes and Postoperative Recurrence Risk in Nasal Polyps DOI
Sijie Jiang,

Liyuan Liu,

Hua Zhang

и другие.

Otolaryngology, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Abstract Objective This study aimed to investigate the association between body mass index (BMI) and histopathological features postoperative recurrence risk of chronic rhinosinusitis with nasal polyps (CRSwNP). Study Design A retrospective clinical study. Setting Recurrent group nonrecurrent group. Methods We recruited CRSwNP patients who underwent functional endoscopic sinus surgery classified them into three groups based on BMI: normal weight, overweight, obesity. All were followed for 3 years divided nonrecurrence groups. The impact BMI analyzed through comparative analysis. Results total 577 completed follow‐up, 197 experiencing recurrence. Recurrence rates, tissue eosinophil counts, interleukin (IL)‐5 IL‐17A expression levels significantly higher in overweight obesity compared weight Additionally, within groups, had elevated counts IL‐5 other two Notably, tissues collected during revision showed increased baseline, particularly obese patients. Both logistic regression analyses Kaplan‐Meier curves indicated that associated an Conclusion Elevated presented significant impacts changes Overweight aggravated infiltration, expressions contributing recurrent mechanisms CRSwNP.

Язык: Английский

Oxidative Stress and Mitochondrial Impairment: Key Drivers in Neurodegenerative Disorders DOI

Pei Wen,

Zhixin Sun,

Fengting Gou

и другие.

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102667 - 102667

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

9
Novel Triazine Derivatives as NLRP3 Inhibitors for Treating Asthma or COPD DOI Creative Commons
Ram W. Sabnis

ACS Medicinal Chemistry Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

InfoMetricsFiguresRef. ACS Medicinal Chemistry LettersASAPArticle This publication is free to access through this site. Learn More CiteCitationCitation and abstractCitation referencesMore citation options ShareShare onFacebookX (Twitter)WeChatLinkedInRedditEmailJump toExpandCollapse Patent HighlightJanuary 24, 2025Novel Triazine Derivatives as NLRP3 Inhibitors for Treating Asthma or COPDClick copy article linkArticle link copied!Ram W. Sabnis*Ram SabnisSmith, Gambrell & Russell LLP, 1105 Peachtree Street NE, Suite 1000, Atlanta, Georgia 30309, United States*E-mail: [email protected]More by Ram Sabnishttps://orcid.org/0000-0001-7289-0581Open PDFACS LettersCite this: Med. Chem. Lett. 2025, XXXX, XXX, XXX-XXXClick citationCitation copied!https://pubs.acs.org/doi/10.1021/acsmedchemlett.5c00020https://doi.org/10.1021/acsmedchemlett.5c00020Published January 2025 Publication History Received 12 2025Published online 24 2025editorialPublished American Chemical Society. available under these Terms of Use. Request reuse permissionsAbstractClick section linkSection copied!High Resolution ImageDownload MS PowerPoint SlideProvided herein are novel triazine derivatives inhibitors, pharmaceutical compositions, use such compounds in treating asthma COPD, processes preparing compounds.This licensed personal The PublicationsPublished Society Important Compound Classes TitleTriazine NumberWO 2025/003288 A1URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2025003288&_cid=P12-M5SZQM-50837-1 DateJanuary 2, Priority ApplicationEP 23182238.8 DateJune 29, 2023 InventorsBon, D.; Bouche, L. A.; Guba, W.; Hargrave, E.; Jaeschke, G.; Johnston, H. J.; Mesch, S. K.; Schnider, C.; Steiner, S.; Tosstorff, A. M. Assignee CompanyF. Hoffmann-La Roche AG, Switzerland, Inc., USA Disease AreaAsthma COPD Biological TargetNLRP3 SummaryThe (NOD)-like receptor (NLR) family, NOD-like protein 3 (NLRP3) inflammasome a component the inflammatory process, its aberrant activity pathogenic inherited disorders cryopyrin-associated periodic syndromes (CAPS) complex diseases multiple sclerosis, Alzheimer's disease, atherosclerosis. an intracellular signaling molecule that senses many pathogen-derived, environmental, host-derived factors. Upon activation, binds apoptosis-associated speck-like containing caspase activation recruitment domain (ASC). ASC then polymerizes form large aggregate known speck. Polymerized turn interacts with cysteine protease caspase-1 termed inflammasome.Active cytokines derived from important drivers inflammation interact other cytokine pathways shape immune response infection injury. A role central nervous system lung emerging. Furthermore, has development liver diseases, kidney aging.The present application describes series inhibitors treatment chronic obstructive pulmonary disease (COPD). Further, discloses compounds, their preparation, use, composition, treatment. DefinitionsA = -O- CH2; R1 hydroxyalkyl acetyl;R2 alkyl; n 0 1. Key Structures AssayThe THP-1 pyroptosis assay was performed. described were tested ability inhibit NLRP3. IC50 values (nM) shown following table. DataThe table below shows representative inhibition biological data obtained testing examples. ClaimsTotal claims: 16Compound 9Pharmaceutical composition 1Method 1Use compound Recent Review ArticlesSee refs (1−5).Author InformationClick copied!Corresponding AuthorRam Sabnis, Smith, States, https://orcid.org/0000-0001-7289-0581, Email: protected]NotesThe author declares no competing financial interest.ReferencesClick copied! references 5 publications. 1Beucher, L.; Gabillard-Lefort, Baris, O. R.; Mialet-Perez, J. Monoamine oxidases: missing between mitochondria diseases. Redox Biol. 2024, 77, 103393, DOI: 10.1016/j.redox.2024.103393 Google ScholarThere corresponding record reference.2Pan, M.; Yang, Jiang, Z. Inflammasomes roles autoimmune Rheumatol. Autoimmun. 4, 197– 217, 10.1002/rai2.12155 reference.3Zhou, H.; Wang, Lv, Yu, allergic diseases: mechanisms therapeutic implications. Clin. Exp. 231, 10.1007/s10238-024-01492-z reference.4Sabnis, R. Fused Bicyclic Heteroaryl Compounds COPD. 2023, 14, 895– 896, 10.1021/acsmedchemlett.3c00236 reference.5Luo, Zhuang, X.; Fu, Dong, Z.; Yi, Y.; Zhao, Hei, F. interplay macrophage glycolytic reprogramming acute injury/acute respiratory distress syndrome. Transl. e70098 10.1002/ctm2.70098 reference.Cited By Click copied!This not yet been cited publications.Download PDFFiguresReferences Get e-AlertsGet e-AlertsACS copied!https://doi.org/10.1021/acsmedchemlett.5c00020Published permissionsArticle Views-Altmetric-Citations-Learn about metrics closeArticle Views COUNTER-compliant sum full text downloads since November 2008 (both PDF HTML) across all institutions individuals. These regularly updated reflect usage leading up last few days.Citations number articles citing article, calculated Crossref daily. Find more information counts.The Altmetric Attention Score quantitative measure attention research received online. Clicking on donut icon will load page at altmetric.com additional details score social media presence given article. how calculated.Recommended Articles FiguresReferencesAbstractHigh SlideReferences There reference.

Язык: Английский

Процитировано

1
Modes of Mitochondrial Reactive Oxygen Species Production in Inflammation DOI
M. P. González-Hernández,

Laura Gallardo-Andalucía,

Pablo Hernansanz‐Agustín

и другие.

Antioxidants and Redox Signaling, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Background: Inflammation is one of the most important pathways in innate immunity and its relationship with redox biology becoming increasingly clear last decades. However, specific modes by which inflammation produced are not yet well defined. Significance: In this review, we provide a general explanation reactive oxygen species (ROS) production quenching occurring mammalian mitochondria, as summary recent advances mitochondrial bioenergetics regarding sodium (Na+) homeostasis. addition, collection examples several inflammatory have been associated either ROS or quenching. Innovation: The role Na+ being developed. Since discovery second messenger, research immune system has emerged. Now, recently identified, owns unprecedented applications. potential implication mechanisms grows does only cover respiration but also control through management membrane potential. Future directions: relevant for biology. Thus, processes bioenergetics, state, metabolism may probably need to include study their road map. Some these involved more possibly come. This review expected serve bridge between both fields. Antioxid. Redox Signal. 00, 000-000.

Язык: Английский

Процитировано

0
Elevated Body Mass Index Aggravates Histopathological Changes and Postoperative Recurrence Risk in Nasal Polyps DOI
Sijie Jiang,

Liyuan Liu,

Hua Zhang

и другие.

Otolaryngology, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Abstract Objective This study aimed to investigate the association between body mass index (BMI) and histopathological features postoperative recurrence risk of chronic rhinosinusitis with nasal polyps (CRSwNP). Study Design A retrospective clinical study. Setting Recurrent group nonrecurrent group. Methods We recruited CRSwNP patients who underwent functional endoscopic sinus surgery classified them into three groups based on BMI: normal weight, overweight, obesity. All were followed for 3 years divided nonrecurrence groups. The impact BMI analyzed through comparative analysis. Results total 577 completed follow‐up, 197 experiencing recurrence. Recurrence rates, tissue eosinophil counts, interleukin (IL)‐5 IL‐17A expression levels significantly higher in overweight obesity compared weight Additionally, within groups, had elevated counts IL‐5 other two Notably, tissues collected during revision showed increased baseline, particularly obese patients. Both logistic regression analyses Kaplan‐Meier curves indicated that associated an Conclusion Elevated presented significant impacts changes Overweight aggravated infiltration, expressions contributing recurrent mechanisms CRSwNP.

Язык: Английский

Процитировано

0