The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 5, 2025

Aortic dissection (AD) is a life-threatening vascular condition marked by the separation or tearing of aortic media. Ferroptosis, form iron-dependent programmed cell death, occurs alongside lipid peroxidation and accumulation reactive oxygen species (ROS). The relationship between ferroptosis AD lies in its damaging effect on cells. In AD, worsens damage to smooth muscle cells (VSMCs) endothelial (ECs), thereby weakening wall’s structural integrity accelerating onset progression condition. However, molecular mechanisms through which regulates remain poorly understood. This article explores AD.

Язык: Английский

The foam cell-derived exosomes exacerbate ischemic white matter injury via transmitting metabolic defects to microglia

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Pretreatment with dimethyl fumarate prevents chronic pain and its comorbidities via Nrf2 pathway in a rat model of neuropathic pain

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский