Mendelian Randomization Analysis Supports a Causal Relationship Between Circulating Inflammatory Proteins and Basal Cell Carcinoma

Clinical Cosmetic and Investigational Dermatology, Год журнала: 2025, Номер Volume 18, С. 767 - 779

Опубликована: Март 1, 2025

It has been shown that the Basal cell carcinoma (BCC) is associated with chronic inflammation of skin conditions, circulating inflammatory protein levels may be a more intuitive index in response to inflammation, however, cause-and-effect relationship between proteins and BCC currently unknown. This study performed Mendelian randomization (MR) analysis using plasma from large genome-wide quantitative trait loci as exposure data, outcome data GWAS for BCC. Inverse variance weighed, MR-Egger, maximum likelihood ratio, weighted median assessing causality MR-Egger regression Cochran's Q statistic were applied sensitivity MRPRESSO was exclude outliers. MR on found causally Six causal obtained, including CCL4, significant protective effect development. IL-18 CCL28, suggestive effects CX3CL1, IL-17A, CSF-1 potential risk factors development According results reverse analysis, there no above-mentioned proteins. two-sample revealed strong association Specifically, IL-18, emerged targets prognostic evaluation treatment However, further experimental studies are needed elucidate specific mechanisms.

Язык: Английский

Micronutrient antioxidant supplementation alleviates Valproic acid-induced oxidative stress and male infertility via the NRF2/HO-1 pathway

Redox Biology, Год журнала: 2025, Номер unknown, С. 103685 - 103685

Опубликована: Май 1, 2025

Язык: Английский