Female Reproductive System
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 743 - 817
Опубликована: Янв. 1, 2025
Язык: Английский
A review of the scientific literature on experimental toxicity studies of COVID-19 vaccines, with special attention to publications in toxicology journals
Archives of Toxicology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 3, 2024
Abstract
Since
the
reports
of
first
cases
COVID-19,
in
less
than
5
years,
a
huge
number
documents
regarding
that
disease
and
coronavirus
(SARS-CoV-2),
responsible
for
infection,
have
been
published.
The
tremendous
scientific
covers
many
topics
on
different
issues
directly
related
to
COVID-19/SARS-CoV-2.
articles—including
reviews—reporting
adverse/side
effects
approved
COVID-19
vaccines
is
considerable.
A
wide
range
reported
humans
after
vaccination:
thrombotic
events/thrombocytopenia,
myocarditis/pericarditis,
cutaneous
reactions,
immune-mediated
effects,
psychiatric
adverse
events,
systemic
lupus
erythematosus,
reproductive
toxicity,
other
miscellaneous
effects.
In
contrast,
information
nonclinical
studies
conducted
assess
potential
toxicity/adverse
laboratory
animals,
comparatively
very
scarce.
present
review
was
aimed
at
revising
literature
animals
toxic/adverse
vaccines.
addition,
investigations
those
specific
toxicology
journals
with
highest
impact
factors
examined
one
by
one.
results
indicate
most
nonclinical/experimental
adverse/toxic
and/or
candidates
showed—in
general
terms—a
good
safety
profile.
Only
some
animal
were
certain
found.
However,
rather
surprising
result
has
limited
available
(in
databases
PubMed
Scopus)
performed
companies
largest
manufacturers
mRNA
world.
It
assumed
these
conducted.
they
not
published
journals,
which
does
allow
judgment
international
community,
including
toxicologists.
Язык: Английский
Adjuvants to increase immunogenicity of SARS-CoV-2 RBD and support maternal–fetal transference of antibodies in mice
Pathogens and Disease,
Год журнала:
2022,
Номер
80(1)
Опубликована: Янв. 1, 2022
Adjuvants
are
important
components
of
vaccines,
increasing
immunogenicity
and
modulating
the
immune
response.
SARS-CoV-2
vaccines
still
being
developed
in
order
to
improve
worldwide
access
immunization.
Specific
populations
should
be
addressed
these
investigations,
such
as
pregnant
women-to
protect
both
mothers
neonates.
In
this
study,
female
adult
mice
were
immunized
with
Receptor-binding
domain
(RBD)
from
adjuvanted
by
a
mixture
DDA
Saponin
put
mating
verify
maternal
transference
IgG.
For
comparison,
other
group
received
RBD
OMVs
Neisseria
meningitidis
Alum.
The
adjuvants
enhanced
IgG
production
neutralization.
DDA/Sap
contributed
increase
IgG1,
IgG2a,
IgG2b,
IgG3
isotypes.
Total
avidity
was
considered
high,
well
IgG2b
avidity.
antibodies
effectively
transferred
offspring,
predominantly
IgG3.
passive
immunoglobulin
maintained
neutralizing
ability,
although
it
lost
ELISA
data
confirmed
Dot-ELISA
immunoblotting
assays.
seem
promising
adjuvant
enhance
humoral
response
antigens.
Further
studies
considering
effects
immunization
protection
offspring
needed,
regardless
platform
used
COVID-19
vaccines.
Язык: Английский
A Review of the Scientific Literature on Experimental Toxicity Studies of COVID-19 Vaccines, with Special Attention to Publications in Specific Toxicology Journals
Опубликована: Июнь 25, 2024
Since
the
reports
of
first
cases
COVID-19,
in
less
than
5
years
a
huge
number
documents
regarding
that
disease
and
coronavirus
(SARS-CoV-2),
responsible
for
infection,
have
been
published.
The
tremendous
scientific
covers
many
topics
on
different
issues
directly
related
to
COVID-19/SARS-CoV-2.
It
includes
studies
about
efficacy
vaccines
prevent
disease.
However,
only
comparatively
low
nonclinical
-conducted
experimental
animals-
focused
potential
adverse/toxic
effects
COVID-19
vaccines.
present
review
was
aimed
at
revising
literature
laboratory
animals
toxic/adverse
In
addition,
investigations
reported
those
specific
toxicology
journals
with
highest
impact
factors
examined
one
by
one.
results
indicate
most
nonclinical/experimental
and/or
candidates
showed
-in
general
terms-
good
safety
profile.
Only
some
animal
were
certain
adverse
found.
rather
surprising
result
has
limited
available
(in
databases
PubMed
Scopus)
performed
companies
largest
manufacturers
mRNA
world
[https://www.google.com/search?sca_esv=ba085665fbb45bd4&sca_upv=1&q=Who+is+the+largest+manufacturer+of+vaccines+in+the+world%3F&sa=X&sqi=2&ved=2ahUKEwj6nMbAi-qGAxVLaqQEHTPwDcIQzmd6BAgZEAY].
Why
these
-assuming,
course,
they
conducted-
not
published
journals,
allowing
judgment
international
community,
including
toxicologists?
Язык: Английский
Advances in the delivery of COVID-19 vaccines
American Journal of Biopharmacy and Pharmaceutical Sciences,
Год журнала:
2022,
Номер
2, С. 5 - 5
Опубликована: Май 7, 2022
Several
systems
are
being
developed
and
investigated
for
the
delivery
of
COVID-19
vaccines.
A
crucial
challenge
is
ability
to
maintain
vaccine
efficacy
through
use
an
effective
system.
Some
these
such
as
lipid
nanoparticles
(LNPs)
have
been
approved
by
regulatory
authorities
in
numerous
countries.
LNPs
currently
used
Moderna
Pfizer/BioNtech
consist
four
constituents:
Cholesterol
LNP
stabilization,
cationic
lipids
protection
messenger
RNA
(mRNA)
molecules
from
nuclease
degradation,
helper
phospholipids
that
aid
formation
intracellular
release
mRNA
PEGylated
reduce
nonspecific
interactions.
Researchers
also
virus-like
particles
(VLPs)
delivery.
VLPs
several
hollow
viral
proteins
without
genome.
structurally
identical
native
virus
can
activate
human
adaptive
immune
response.
The
nanosized
self-assemblies
potential
platforms
Liposomal
vesicles
amphiphilic
since
polar
headgroups
oriented
toward
water
hydrophobic
chains
internal
area
vesicles.
rationale
behind
utilization
liposomes
their
versatility
flexibility.
Messenger
coding
SARS-CoV-2
spike
protein
be
entrapped
into
designed
remain
stable
bloodstream
until
uptake
phagocytic
cells.
Other
approaches
microneedles
electroporation
provide
transdermal
transport
enable
vaccines
cross
skin
but
not
cells
deep-lying
tissues.
Язык: Английский
SARS-CoV-2-Infektion, Corona-Impfung und Reproduktion
Geburtshilfe und Frauenheilkunde,
Год журнала:
2022,
Номер
unknown
Опубликована: Июнь 1, 2022
Einleitung
Vor
allem
junge
Frauen
und
Männer
mit
(zukünftigem)
Kinderwunsch
äußern
die
Angst,
dass
eine
Corona
Impfung
zu
einer
Infertilität
bzw.
erhöhten
Abortrate
negativen
Langzeitfolgen
für
das
Kind
führen
könnte.
Ärztliche
Kolleg:innen
sorgen
sich
hingegen
mehr
hinsichtlich
der
Auswirkungen
SARS-CoV-2
Infektion
auf
Reproduktion.