Geburtshilfe und Frauenheilkunde, Год журнала: 2022, Номер unknown
Опубликована: Июнь 1, 2022
Einleitung Vor allem junge Frauen und Männer mit (zukünftigem) Kinderwunsch äußern die Angst, dass eine Corona Impfung zu einer Infertilität bzw. erhöhten Abortrate negativen Langzeitfolgen für das Kind führen könnte. Ärztliche Kolleg:innen sorgen sich hingegen mehr hinsichtlich der Auswirkungen SARS-CoV-2 Infektion auf Reproduktion.
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 743 - 817
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3
Archives of Toxicology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 3, 2024
Abstract Since the reports of first cases COVID-19, in less than 5 years, a huge number documents regarding that disease and coronavirus (SARS-CoV-2), responsible for infection, have been published. The tremendous scientific covers many topics on different issues directly related to COVID-19/SARS-CoV-2. articles—including reviews—reporting adverse/side effects approved COVID-19 vaccines is considerable. A wide range reported humans after vaccination: thrombotic events/thrombocytopenia, myocarditis/pericarditis, cutaneous reactions, immune-mediated effects, psychiatric adverse events, systemic lupus erythematosus, reproductive toxicity, other miscellaneous effects. In contrast, information nonclinical studies conducted assess potential toxicity/adverse laboratory animals, comparatively very scarce. present review was aimed at revising literature animals toxic/adverse vaccines. addition, investigations those specific toxicology journals with highest impact factors examined one by one. results indicate most nonclinical/experimental adverse/toxic and/or candidates showed—in general terms—a good safety profile. Only some animal were certain found. However, rather surprising result has limited available (in databases PubMed Scopus) performed companies largest manufacturers mRNA world. It assumed these conducted. they not published journals, which does allow judgment international community, including toxicologists.
Язык: Английский
Процитировано
2
Pathogens and Disease, Год журнала: 2022, Номер 80(1)
Опубликована: Янв. 1, 2022
Adjuvants are important components of vaccines, increasing immunogenicity and modulating the immune response. SARS-CoV-2 vaccines still being developed in order to improve worldwide access immunization. Specific populations should be addressed these investigations, such as pregnant women-to protect both mothers neonates. In this study, female adult mice were immunized with Receptor-binding domain (RBD) from adjuvanted by a mixture DDA Saponin put mating verify maternal transference IgG. For comparison, other group received RBD OMVs Neisseria meningitidis Alum. The adjuvants enhanced IgG production neutralization. DDA/Sap contributed increase IgG1, IgG2a, IgG2b, IgG3 isotypes. Total avidity was considered high, well IgG2b avidity. antibodies effectively transferred offspring, predominantly IgG3. passive immunoglobulin maintained neutralizing ability, although it lost ELISA data confirmed Dot-ELISA immunoblotting assays. seem promising adjuvant enhance humoral response antigens. Further studies considering effects immunization protection offspring needed, regardless platform used COVID-19 vaccines.
Язык: Английский
Процитировано
7
Опубликована: Июнь 25, 2024
Since the reports of first cases COVID-19, in less than 5 years a huge number documents regarding that disease and coronavirus (SARS-CoV-2), responsible for infection, have been published. The tremendous scientific covers many topics on different issues directly related to COVID-19/SARS-CoV-2. It includes studies about efficacy vaccines prevent disease. However, only comparatively low nonclinical -conducted experimental animals- focused potential adverse/toxic effects COVID-19 vaccines. present review was aimed at revising literature laboratory animals toxic/adverse In addition, investigations reported those specific toxicology journals with highest impact factors examined one by one. results indicate most nonclinical/experimental and/or candidates showed -in general terms- good safety profile. Only some animal were certain adverse found. rather surprising result has limited available (in databases PubMed Scopus) performed companies largest manufacturers mRNA world [https://www.google.com/search?sca_esv=ba085665fbb45bd4&sca_upv=1&q=Who+is+the+largest+manufacturer+of+vaccines+in+the+world%3F&sa=X&sqi=2&ved=2ahUKEwj6nMbAi-qGAxVLaqQEHTPwDcIQzmd6BAgZEAY]. Why these -assuming, course, they conducted- not published journals, allowing judgment international community, including toxicologists?
Язык: Английский
Процитировано
0
American Journal of Biopharmacy and Pharmaceutical Sciences, Год журнала: 2022, Номер 2, С. 5 - 5
Опубликована: Май 7, 2022
Several systems are being developed and investigated for the delivery of COVID-19 vaccines. A crucial challenge is ability to maintain vaccine efficacy through use an effective system. Some these such as lipid nanoparticles (LNPs) have been approved by regulatory authorities in numerous countries. LNPs currently used Moderna Pfizer/BioNtech consist four constituents: Cholesterol LNP stabilization, cationic lipids protection messenger RNA (mRNA) molecules from nuclease degradation, helper phospholipids that aid formation intracellular release mRNA PEGylated reduce nonspecific interactions. Researchers also virus-like particles (VLPs) delivery. VLPs several hollow viral proteins without genome. structurally identical native virus can activate human adaptive immune response. The nanosized self-assemblies potential platforms Liposomal vesicles amphiphilic since polar headgroups oriented toward water hydrophobic chains internal area vesicles. rationale behind utilization liposomes their versatility flexibility. Messenger coding SARS-CoV-2 spike protein be entrapped into designed remain stable bloodstream until uptake phagocytic cells. Other approaches microneedles electroporation provide transdermal transport enable vaccines cross skin but not cells deep-lying tissues.
Язык: Английский
Процитировано
0
Geburtshilfe und Frauenheilkunde, Год журнала: 2022, Номер unknown
Опубликована: Июнь 1, 2022
Einleitung Vor allem junge Frauen und Männer mit (zukünftigem) Kinderwunsch äußern die Angst, dass eine Corona Impfung zu einer Infertilität bzw. erhöhten Abortrate negativen Langzeitfolgen für das Kind führen könnte. Ärztliche Kolleg:innen sorgen sich hingegen mehr hinsichtlich der Auswirkungen SARS-CoV-2 Infektion auf Reproduktion.
Процитировано
0