Oxidative-Stress-Mediated Epigenetic Dysregulation in Spermatogenesis: Implications for Male Infertility and Offspring Health

Genes, Год журнала: 2025, Номер 16(1), С. 93 - 93

Опубликована: Янв. 17, 2025

Male reproductive health is governed by an intricate interplay of genetic, epigenetic, and environmental factors. Epigenetic mechanisms—encompassing DNA methylation, histone modifications, non-coding RNA activity—are crucial both for spermatogenesis sperm maturation. However, oxidative stress, driven excessive reactive oxygen species, disrupts these processes, leading to impaired function male infertility. This disruption extends epigenetic resulting in abnormal gene expression chromatin remodeling that compromise genomic integrity fertilization potential. Importantly, oxidative-stress-induced alterations can be inherited, affecting the fertility offspring future generations. review investigates how stress influences regulation reproduction modifying RNAs, ultimately compromising spermatogenesis. Additionally, it discusses transgenerational implications disruptions their potential role hereditary infertility disease predisposition. Understanding mechanisms vital developing therapeutic strategies mitigate damage restore homeostasis germline. By integrating insights from molecular, clinical, research, this work emphasizes need targeted interventions enhance prevent adverse outcomes progeny. Furthermore, elucidating dose–response relationships between changes remains a critical research priority, informing personalized diagnostics interventions. In context, studies should adopt standardized markers damage, robust clinical trials, multi-omic approaches capture complexity Such rigorous investigations will reduce risk disorders optimize outcomes.

Язык: Английский

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Oxidative Stress-Associated Male Infertility: Current Diagnostic and Therapeutic Approaches

Medicina, Год журнала: 2024, Номер 60(6), С. 1008 - 1008

Опубликована: Июнь 20, 2024

Infertility is a prevalent global issue affecting approximately 17.5% of adults, with sole male factor contributing to 20–30% cases. Oxidative stress (OS) critical in infertility, disrupting the balance between reactive oxygen species (ROS) and antioxidants. This imbalance detrimentally affects sperm function viability, ultimately impairing fertility. OS also triggers molecular changes sperm, including DNA damage, lipid peroxidation, alterations protein expression, further compromising functionality potential fertilization. Diagnostic tools discussed this review offer insights into markers, antioxidant levels, intracellular ROS concentrations. By accurately assessing these parameters, clinicians can diagnose infertility more effectively thus tailor treatment plans individual patients. Additionally, explores various options for males OS-associated such as empirical drugs, antioxidants, nanoantioxidants, lifestyle modifications. addressing root causes implementing targeted interventions, optimize outcomes enhance chances conception couples struggling infertility.

Язык: Английский

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Deciphering the Role of Oxidative Stress in Male Infertility: Insights from Reactive Oxygen Species to Antioxidant Therapeutics

Frontiers in Bioscience-Landmark, Год журнала: 2025, Номер 30(4)

Опубликована: Март 31, 2025

Male infertility represents a major health concern, accounting for approximately 50% of all cases in couples. This condition arises from multiple etiologies, with oxidative stress gaining increasing attention recent studies. During the final stages sperm maturation, majority cytoplasm is discarded, leaving diminished antioxidant defense system, which makes them highly susceptible to detrimental effects reactive oxygen species (ROS). ROS can be generated both intrinsic and extrinsic sources. Intrinsically, are primarily produced by mitochondrial activity, while factors include alcohol consumption, smoking, circadian rhythm disruption, gut microbiota imbalance, leukocyte infiltration. Excessive production leads DNA damage, apoptosis, epigenetic modifications sperm, ultimately impairing motility contributing infertility. review provides comprehensive examination sources examines mechanisms induce damage. Furthermore, it explores therapeutic potential antioxidants mitigating improving quality.

Язык: Английский

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Efficacy and Safety of Visible and Near-Infrared Photobiomodulation Therapy on Astenospermic Human Sperm: Wavelength-Dependent Regulation of Nitric Oxide Levels and Mitochondrial Energetics

Biology, Год журнала: 2025, Номер 14(5), С. 491 - 491

Опубликована: Май 1, 2025

Male infertility is a growing global concern, with asthenozoospermia being an important contributing factor. Mitochondrial dysfunction and changes in the metabolism of nitric oxide (NO) are key determinants reduced sperm motility. This study investigates effects photobiomodulation (PBM) visible near-infrared (NIR) laser light on asthenozoospermic patients, focusing mitochondrial energetic status, oxidative stress, NO dynamics. Semen samples were irradiated at 450 nm, 635 810 940 1064 nm different power levels (0.25, 0.50, 1.00, 2.00 W) for 60 s spot area 1 cm2. ATP AMP levels, stress markers, concentrations assessed 10 min after irradiation, ATP/AMP ratio calculated as index cellular energy balance. The results show that PBM modulates status spermatozoa way dependent wavelength dose. Irradiation produced most marked improvement whereas exposure led to significant decrease levels. showed biphasic response, correlated range nm. induced higher production respect other wavelengths. Our findings suggest mainly involves photoreceptors potentially heme flavin groups synthases, facilitating electron transitions, enhancing effectiveness phosphorylation, optimizing enzymatic activity. At longer wavelengths (940 nm), interactions water lipids may introduce additional variables affect membrane fluidity function differently from shorter

Язык: Английский

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Micronutrient Antioxidants for Men (Menevit®) Improve Sperm Function by Reducing Oxidative Stress, Resulting in Improved Assisted Reproductive Technology Outcomes

Antioxidants, Год журнала: 2024, Номер 13(6), С. 635 - 635

Опубликована: Май 23, 2024

Oxidative stress (OS) affects men’s health and impairs spermatogenesis. Micronutrient antioxidants are available for male infertility as complemental support; however, their efficacy remains debatable. This study aimed to investigate whether can help reduce sperm OS improve semen analysis quality. We included 171 partners of couples planning undergo assisted reproductive technology (ART). Male partners, aged 29–41 years, intending conceive were self-selected take daily (n = 84) containing folic acid zinc, or not 52) 6 months. analyzed the alterations in serum oxidant levels, parameters, OS, deoxyribonucleic fragmentation after 3 Additionally, implantation, clinical pregnancy, miscarriage rates vitrified–warmed embryo transfer compared between those taking them In men with high static oxidation–reduction potential (sORP), we observed a significant improvement concentration sORP. The high-quality blastocyst rate tended increase, implantation pregnancy also significantly increased months intervention. micronutrient could function by reducing improving ART outcomes. Therefore, may be viable treatment option infertility.

Язык: Английский

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A critical review of the recent concept of regulatory performance of DNA Methylations, and DNA methyltransferase enzymes alongside the induction of immune microenvironment elements in recurrent pregnancy loss

Toxicology Reports, Год журнала: 2024, Номер 12, С. 546 - 563

Опубликована: Май 9, 2024

Recurrent pregnancy Loss (RPL)is a frequent and upsetting condition. Besides the prevalent cause of RPL including chromosomal defects in embryo,the effect translational elements like alterations epigenetics are great importance. The emergence has offered fresh outlook on causes treatment by focusing examination DNA methylation. may arise as result aberrant methylation imprinted genes, placenta-specific immune-related sperm DNA, which have direct or indirect impact embryo implantation, growth, development. Moreover, distinct immunological tolerogenic milieu established at interface between mother fetus plays crucial role sustaining pregnancy. Given this, there been deal interest regulation cellular components maternal-fetal milieu. research methylation's incidence control mother-fetal is summed up this review.

Язык: Английский

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Unfolding the complexity of epigenetics in male reproductive aging: a review of therapeutic implications

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Авг. 1, 2024

Язык: Английский

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Effect of the defoliant tribufos on the reproductive ability of Japanese quail (Coturnix japonica)

Chemosphere, Год журнала: 2024, Номер 352, С. 141430 - 141430

Опубликована: Фев. 9, 2024

Язык: Английский

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Behind the Genetics: The Role of Epigenetics in Infertility-Related Testicular Dysfunction

Life, Год журнала: 2024, Номер 14(7), С. 803 - 803

Опубликована: Июнь 26, 2024

In recent decades, we have witnessed a progressive decline in male fertility. This is partly related to the increased prevalence of chronic diseases (e.g., obesity and diabetes mellitus) risky lifestyle behaviors. These conditions alter fertility through various non-genetic mechanisms. However, there increasing evidence that they are also capable causing sperm epigenetic alterations, which, turn, can cause infertility. Furthermore, these modifications could be transmitted offspring, altering their general reproductive health. Therefore, represent one causes count recorded decades. review focuses on highlighting at level induced by detail, effects DNA methylation, histone modifications, expression profiles non-coding RNAs evaluated. Finally, focus risk transgenerational inheritance presented. Our narrative aims demonstrate how certain gene expression, potentially leading transmission anomalies future generations. It emphasizes importance early detection treatment reversible (such as varicocele) modification Addressing issues crucial for individual health, preserving fertility, ensuring well-being

Язык: Английский

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Güncel Jinekoloji Hemşireliği III

Опубликована: Июнь 3, 2024

Üriner İnkontinanslı Kadınlarda Pelvik Taban Kas Egzersizinin Rolü Hamide ARSLAN TARUS Nurdan DEMİRCİ Jinekolojik Kanserler Türleri, Epidemiyolojisi, Belirtileri, Risk Faktörleri ve Evreleme Nursa. B.Y.K Nevin HOTUN ŞAHİN Kanserlerde Hemşirelerin TAT Uygulamalarındaki Yetkinliği Nurşah BOYLU BALTACI Tamamlayıcı Alternatif Yaklaşımlar Cansu AĞRALI Endometrioziste Kanıt Temelli Uygulamalar Ayşe Gül BURSA Menopoz Döneminde Sağlıklı Yaşam Davranışları G.lnihal ARTUĞ CANSIZLAR Göçmen Cinsel Şiddet Koruyucu Sağlık Hizmetlerinde Rolleri Şirin ÇELİK Erkek Faktörlü İnfertilitede Yaşanan Psikososyal Sorunlar Meyase DEMİR Eda CANGÖL Ağrı Esra TAVUKÇU Hotun Organ Prolapsusu Hemşirelik Bakımı Burcu FIRAT

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