The mechanisms of tripterygium glycosides-induced reproductive toxicity and detoxification strategies

Reproductive Toxicology, Год журнала: 2025, Номер 132, С. 108830 - 108830

Опубликована: Янв. 6, 2025

Язык: Английский

Research Progress on Reproductive Toxicity and Reversibility of Tripterygium wilfordii Based on Gender Differences

Pharmacognosy Magazine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Tripterygium wilfordii Hook F. (TwHF), a member of the Celastraceae family and belonging to genus Tripterygium, is vine-like shrub. It contains numerous active components, such as glycosides (GTW) triptolide (TP), widely known for their significant reproductive toxicity. This toxicity characterized by its detrimental effects on testes ovaries, leading reduced libido, apoptosis germ follicle cells, abnormal secretion sex hormones. Thus, it necessary explore mechanisms behind TwHF’s toxicity, which will lead advancements in detoxification efficacy enhancement strategies. article offers comprehensive overview analysis research conducted reversibility induced TwHF, aiming provide reference rational use clinical settings.

Язык: Английский

Targeting Metabolic Diseases with Celastrol: A Comprehensive Review of Anti-Inflammatory Mechanisms and Therapeutic Potential

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119560 - 119560

Опубликована: Фев. 1, 2025

Язык: Английский