Therapeutic effect of berberine against 5-fluorouracil induced ovarian toxicity in rats DOI
Selim Demir, Nihal Türkmen Alemdar, Hatice Küçük

и другие.

Biotechnic & Histochemistry, Год журнала: 2024, Номер unknown, С. 1 - 7

Опубликована: Окт. 23, 2024

Berberine (BER) is a naturally occurring alkaloid with multitude of beneficial effects on human health. Although it one the most studied phytochemicals, its curative effect against ovarian damage caused by 5-fluorouracil (5-FU) has not been demonstrated to date. The aim this study was investigate possible protective BER 5-FU-induced ovotoxicity, focusing ability attenuate oxidative stress, inflammation and apoptosis. 30 female rats were randomly divided into five groups: Control, (2 mg/kg), 5-FU (100 5-FU+BER (1 mg/kg) mg/kg). levels malondialdehyde (MDA), total oxidant status (TOS), antioxidant (TAS), superoxide dismutase (SOD), catalase (CAT), 8-hydroxy-2'-deoxyguanosine (8-OHdG), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) caspase-3 determined using spectrophotometric methods. In addition, samples evaluated histopathologically hematoxylin&eosin staining method. MDA, TOS, 8-OHdG, IL-6, TNF-α significantly increased administration. Also, we found that decreased TAS, SOD CAT levels. Treatments attenuated via increasing capacity reducing apoptosis in dose-dependent manner. Moreover, ovoprotective also confirmed histopathological evaluation. may be as potential candidate molecule reduce toxicity.

Язык: Английский

Relieving 5-fluorouracil-associated testicular toxicity in rats: Investigating the therapeutic potential of arbutin DOI
Elif Ayazoğlu Demir, Selim Demir,

Zeynep Turkmen Usta

и другие.

South African Journal of Botany, Год журнала: 2025, Номер 179, С. 22 - 30

Опубликована: Фев. 8, 2025

Язык: Английский

Процитировано

0
Can we really protect the ovary from chemotherapy damage? DOI

Thuy Truong An Nguyen,

M. Condorelli, Isabelle Demeestere

и другие.

Best Practice & Research Clinical Obstetrics & Gynaecology, Год журнала: 2025, Номер 99, С. 102603 - 102603

Опубликована: Март 1, 2025

Future alternatives to current fertility preservation methods such as pharmacological strategies prevent chemotherapy-induced ovarian damage in female cancer patients are of growing interest. Chemotherapeutic agents, especially alkylating cause DNA and apoptosis follicles, significantly reducing reserve. To mitigate this gonadotoxicity, various emerging being explored, including kinase inhibitors, PI3K/Akt/mTOR pathway antioxidants, miRNAs GnRH agonists. These treatments work by preventing follicular or excessive activation primordial follicles. Although promising results have been observed vitro vivo rodent models, further investigations bypass their limitations needed confirm efficacy safety. challenges include the non-interference with anti-tumoral effect chemotherapy specificity fertoprotective agents ovaries.

Язык: Английский

Процитировано

0
Therapeutic effect of berberine against 5-fluorouracil induced ovarian toxicity in rats DOI
Selim Demir, Nihal Türkmen Alemdar, Hatice Küçük

и другие.

Biotechnic & Histochemistry, Год журнала: 2024, Номер unknown, С. 1 - 7

Опубликована: Окт. 23, 2024

Berberine (BER) is a naturally occurring alkaloid with multitude of beneficial effects on human health. Although it one the most studied phytochemicals, its curative effect against ovarian damage caused by 5-fluorouracil (5-FU) has not been demonstrated to date. The aim this study was investigate possible protective BER 5-FU-induced ovotoxicity, focusing ability attenuate oxidative stress, inflammation and apoptosis. 30 female rats were randomly divided into five groups: Control, (2 mg/kg), 5-FU (100 5-FU+BER (1 mg/kg) mg/kg). levels malondialdehyde (MDA), total oxidant status (TOS), antioxidant (TAS), superoxide dismutase (SOD), catalase (CAT), 8-hydroxy-2'-deoxyguanosine (8-OHdG), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) caspase-3 determined using spectrophotometric methods. In addition, samples evaluated histopathologically hematoxylin&eosin staining method. MDA, TOS, 8-OHdG, IL-6, TNF-α significantly increased administration. Also, we found that decreased TAS, SOD CAT levels. Treatments attenuated via increasing capacity reducing apoptosis in dose-dependent manner. Moreover, ovoprotective also confirmed histopathological evaluation. may be as potential candidate molecule reduce toxicity.

Язык: Английский

Процитировано

1