Analysis of the basement membrane-related genes ITGA7 and its regulatory role in periodontitis via machine learning: a retrospective study DOI Creative Commons

Huihuang Ye,

Xue Gao,

Yike Ma

и другие.

BMC Oral Health, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 24, 2024

Periodontitis is among the most prevalent inflammatory conditions and greatly impacts oral health. This study aimed to elucidate role of basement membrane-related genes in pathogenesis diagnosis periodontitis. GSE10334 was used for identification hub via differential analysis, protein-protein interaction network, MCC DMNC algorithms, evaluation LASSO regression support vector machine analysis identify markers patients with Findings were validated by GSE16134 dataset quantitative reverse transcription PCR. The regulatory interplay lncRNAs, miRNAs, mRNAs investigated through multiple databases. Immune infiltration performed assess immune landscape ITGA7 identified as a key gene periodontitis, supported learning validation expression, receiver operating characteristic from external datasets. revealed significant associations between expression numerous cells implicated Additionally, our findings suggest that lncRNA LINC-PINT significantly increased it can modulate hsa-miR-1293. potential diagnostic therapeutic target LINC-PINT/hsa-miR-1293/ITGA7 axis relationship provide new insights into molecular mechanisms underlying periodontitis highlight avenues clinical intervention.

Язык: Английский

Tectochrysin Alleviates Periodontitis by Modulating M2/M1 Macrophage Ratio and Oxidative Stress Via Nuclear Factor Kappa B/Heme Oxygenase-1/Nuclear Factor Erythroid 2-Related Factor 2 Pathway DOI

Ye Yin,

Yi-Ming Weng,

Zeyu Ma

и другие.

Immunological Investigations, Год журнала: 2024, Номер unknown, С. 1 - 15

Опубликована: Окт. 29, 2024

Background Tectochrysin suppresses several diseases. In this study, we aimed to explore the effects of tectochrysin ona rat model periodontitis PDS).

Язык: Английский

Процитировано

1
Analysis of the basement membrane-related genes ITGA7 and its regulatory role in periodontitis via machine learning: a retrospective study DOI Creative Commons

Huihuang Ye,

Xue Gao,

Yike Ma

и другие.

BMC Oral Health, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 24, 2024

Periodontitis is among the most prevalent inflammatory conditions and greatly impacts oral health. This study aimed to elucidate role of basement membrane-related genes in pathogenesis diagnosis periodontitis. GSE10334 was used for identification hub via differential analysis, protein-protein interaction network, MCC DMNC algorithms, evaluation LASSO regression support vector machine analysis identify markers patients with Findings were validated by GSE16134 dataset quantitative reverse transcription PCR. The regulatory interplay lncRNAs, miRNAs, mRNAs investigated through multiple databases. Immune infiltration performed assess immune landscape ITGA7 identified as a key gene periodontitis, supported learning validation expression, receiver operating characteristic from external datasets. revealed significant associations between expression numerous cells implicated Additionally, our findings suggest that lncRNA LINC-PINT significantly increased it can modulate hsa-miR-1293. potential diagnostic therapeutic target LINC-PINT/hsa-miR-1293/ITGA7 axis relationship provide new insights into molecular mechanisms underlying periodontitis highlight avenues clinical intervention.

Язык: Английский

Процитировано

0