Flow Dynamics in Brain Aneurysms: A Review of Computational and Experimental Studies DOI Creative Commons

Prantik Roy Chowdhury,

Victor K. Lai, Ruihang Zhang

и другие.

Biomechanics, Год журнала: 2025, Номер 5(2), С. 36 - 36

Опубликована: Июнь 1, 2025

A brain aneurysm is a structural deterioration of the arterial wall in brain, resulting formation bulge or ballooning blood vessel. Around 3–5% global population affected by aneurysms, wherein only small fraction results rupture. Although an unruptured typically asymptomatic and not immediately life threatening, it poses potential risk rupture, which can lead to severe health complications mortality. Therefore, crucial detect treat aneurysms during phase. Moreover, comprehensive understanding flow dynamics within its parent artery essential for accurate diagnosis prevention recurrence. While prior reviews have focused on computational fluid (CFD) studies particularly patient-specific models from conducted over decade ago, more recent review necessary. Additionally, reviewing various dynamic behavior treated crucial. Thus, advancements both experimental must be explored better understand their underlying mechanisms develop robust treatment strategies. This aims summarize different types screening processes, key hemodynamic factors, characteristics observed before after treatment.

Язык: Английский

The Impact of Polydimethylsiloxane (PDMS) in Engineering: Recent Advances and Applications DOI Creative Commons
Rui Lima

Fluids, Год журнала: 2025, Номер 10(2), С. 41 - 41

Опубликована: Фев. 9, 2025

Since the introduction of polydimethylsiloxane (PDMS) microfluidic devices at beginning 21st century, this elastomeric polymer has gained significant attention in engineering community due to its biocompatibility, exceptional mechanical and optical properties, thermal stability, versatility. PDMS been widely used for vitro experiments ranging from macro- nanoscale, enabling advances blood flow studies, biomodels improvement, numerical validations. devices, including systems, have employed investigate different kinds fluids phenomena such as flow, analogues, deformation individual cells cell free layer (CFL). The most recent applications involve complex hemodynamic studies aneurysms organ-on-a-chip (OoC) platforms. Furthermore, distinctive properties PDMS, transparency, versality inspired innovative beyond biomedical applications, development transparent, virus-protective face masks, those SARS-CoV-2 serpentine heat exchangers enhance transfer energy efficiency systems. This review provides a comprehensive overview current research performed with outlines some future directions, particular engineering, biomicrofluidics, biomodels, transfer, masks. Additionally, challenges related hydrophobicity, molecule absorption, long-term stability are discussed alongside solutions proposed studies.

Язык: Английский

Процитировано

3
Fenestrations of cerebral arteries and their correlation with brain aneurysms DOI Creative Commons

Mila Ćetković,

Jelena Boljanović,

Ema Bexheti

и другие.

Frontiers in Neuroanatomy, Год журнала: 2025, Номер 19

Опубликована: Март 26, 2025

Fenestration of the intracranial artery is an anatomical remnant from embryonic development vascular system. A cerebral aneurysm a focal pathological dilation arterial wall. The occurrence at site fenestration rare in circulation but may have potential clinical implications. This study aimed to identify frequencies fenestrations and aneurysms, their locations, relationships. vasculature 35 adult brains was used for micromorphological dissection analysis under stereoscopic microscope, following injection with mixture formaldehyde, melted gelatin, solution India ink. Additionally, we analyzed another group casts obtained 15 injected methyl methacrylate (MMA). M1 segment middle (MCA) sectioned histological analysis. We also examined computed tomography (CT) angiograms 1,230 patients, data, compared findings observations. In our 50 specimens, were found 12 (24%), affecting different arteries, three cases showing double on same vessel. Aneurysms observed six (12%), always one per brain, case (2.00%) involving associated wall fenestration. Analysis CT patients showed 26 (2.11%) 28 aneurysms (2.28%), (0.08%) where arose presence fenestrated phenomenon, occurring far less frequently than isolated or formation.

Язык: Английский

Процитировано

0
Flow Dynamics in Brain Aneurysms: A Review of Computational and Experimental Studies DOI Creative Commons

Prantik Roy Chowdhury,

Victor K. Lai, Ruihang Zhang

и другие.

Biomechanics, Год журнала: 2025, Номер 5(2), С. 36 - 36

Опубликована: Июнь 1, 2025

A brain aneurysm is a structural deterioration of the arterial wall in brain, resulting formation bulge or ballooning blood vessel. Around 3–5% global population affected by aneurysms, wherein only small fraction results rupture. Although an unruptured typically asymptomatic and not immediately life threatening, it poses potential risk rupture, which can lead to severe health complications mortality. Therefore, crucial detect treat aneurysms during phase. Moreover, comprehensive understanding flow dynamics within its parent artery essential for accurate diagnosis prevention recurrence. While prior reviews have focused on computational fluid (CFD) studies particularly patient-specific models from conducted over decade ago, more recent review necessary. Additionally, reviewing various dynamic behavior treated crucial. Thus, advancements both experimental must be explored better understand their underlying mechanisms develop robust treatment strategies. This aims summarize different types screening processes, key hemodynamic factors, characteristics observed before after treatment.

Язык: Английский

Процитировано

0