Association of Rest Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population (Preprint) DOI
Shahab Haghayegh, Chenlu Gao, Elizabeth Sugg

и другие.

Опубликована: Дек. 11, 2023

BACKGROUND The relationship between 24-hour rest-activity rhythms (RARs) and risk for dementia or mild cognitive impairment (MCI) remains an area of growing interest. Previous studies were often limited by small sample sizes, short follow-ups, older participants. More are required to fully explore the link disrupted RARs MCI in middle-aged adults. OBJECTIVE We leveraged UK Biobank data examine how RAR disturbances correlate with developing METHODS analyzed 91,517 participants aged 43 79 years. Wrist actigraphy recordings used derive nonparametric metrics, including activity level most active 10-hour period (M10) its midpoint, least 5-hour (L5) relative amplitude (RA) cycle [RA=(M10-L5)/(M10+L5)], interdaily stability, intradaily variability, as well acrophase (cosinor analysis). Cox proportional hazards models associations baseline subsequent incidence MCI, adjusting demographic characteristics, comorbidities, lifestyle factors, shiftwork status, genetic Alzheimer's disease. RESULTS During follow-up up 7.5 years, 555 developed dementia. increased those lower M10 (hazard ratio [HR] 1.28, 95% CI 1.14-1.44, per 1-SD decrease), higher L5 (HR 1.15, 1.10-1.21, increase), RA 1.23, 1.16-1.29, 1.32, 1.17-1.49, variability 1.14, 1.05-1.24, increase) advanced midpoint 0.92, 0.85-0.99, advance). These similar people <70 >70 non–shift workers, they independent cardiovascular factors. No significant observed acrophase. CONCLUSIONS Based on findings from a large middle-to-older adults objective assessment almost 8-years follow-up, we suggest that suppressed fragmented daily precede onset may serve biomarkers preclinical

Язык: Английский

Association of Rest Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population (Preprint) DOI
Shahab Haghayegh, Chenlu Gao, Elizabeth Sugg

и другие.

Опубликована: Дек. 11, 2023

BACKGROUND The relationship between 24-hour rest-activity rhythms (RARs) and risk for dementia or mild cognitive impairment (MCI) remains an area of growing interest. Previous studies were often limited by small sample sizes, short follow-ups, older participants. More are required to fully explore the link disrupted RARs MCI in middle-aged adults. OBJECTIVE We leveraged UK Biobank data examine how RAR disturbances correlate with developing METHODS analyzed 91,517 participants aged 43 79 years. Wrist actigraphy recordings used derive nonparametric metrics, including activity level most active 10-hour period (M10) its midpoint, least 5-hour (L5) relative amplitude (RA) cycle [RA=(M10-L5)/(M10+L5)], interdaily stability, intradaily variability, as well acrophase (cosinor analysis). Cox proportional hazards models associations baseline subsequent incidence MCI, adjusting demographic characteristics, comorbidities, lifestyle factors, shiftwork status, genetic Alzheimer's disease. RESULTS During follow-up up 7.5 years, 555 developed dementia. increased those lower M10 (hazard ratio [HR] 1.28, 95% CI 1.14-1.44, per 1-SD decrease), higher L5 (HR 1.15, 1.10-1.21, increase), RA 1.23, 1.16-1.29, 1.32, 1.17-1.49, variability 1.14, 1.05-1.24, increase) advanced midpoint 0.92, 0.85-0.99, advance). These similar people <70 >70 non–shift workers, they independent cardiovascular factors. No significant observed acrophase. CONCLUSIONS Based on findings from a large middle-to-older adults objective assessment almost 8-years follow-up, we suggest that suppressed fragmented daily precede onset may serve biomarkers preclinical

Язык: Английский

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