A spectrophotometric analysis of extracted water-soluble phenolic metabolites of lichens

Planta, Год журнала: 2024, Номер 260(2)

Опубликована: Июль 2, 2024

Abstract Main conclusion Rainwater most probably constitutes a relatively effective solvent for lichen substances in nature which have the potential to provide human and environmental needs future. The aims were (i) test hypothesis on solubility of phenolic compounds using rainwater under conditions that partly reflect natural environment (ii) propose new methods water extraction substances. results spectrophotometric analyses total metabolites rainwater-based extracts from epigeic epiphytic lichens, employing Folin–Ciocalteu (F.–C.) method, are presented. was tested at three pH levels: natural, 3, 9. Extraction undertaken two perspectives: partial imitation use economic purposes. From an ecological perspective, room-temperature (‘cold’ method) used 10-, 60-, 120-min periods. A variant analogous time intervals ‘insolation’ with 100W light bulb simulate heat energy sun. For purposes, method Soxhlet apparatus its modified version, ‘tea-extraction’ (‘hot’ ones). showed those extractions without external source almost ineffective, but insolation over 60- periods proved be more effective. Both ‘hot’ also effective, especially one. Generally, increase concentration resulted increasing pH. show probable involvement biogeochemical processes their promising variety necessities.

Язык: Английский

Gyrophoric Acid, a Secondary Metabolite of Lichens, Exhibits Antidepressant and Anxiolytic Activity In Vivo in Wistar Rats

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11840 - 11840

Опубликована: Ноя. 4, 2024

Gyrophoric acid (GA) is a secondary metabolite of various lichens. It exhibits biological activities in vitro, but only one study has been carried out vivo. Because our previous showed that GA stimulates neurogenesis healthy rats, the current aimed to explore potential during stress-induced depressive-like states male Wistar rats. In experiment, pregnant females were used. last week pregnancy, subjected restraint stress. After birth, progeny aged 60 days stressed repeatedly. The males divided into three groups: control animals (CTR; n = 10), with depression-like state (DEP; and GA-treated (GA; 10). treated (per os 10 mg/kg) daily for month, starting from 60th postnatal day. Our results indicate acts as an antioxidant, shown by lowered ROS level leukocytes (p < 0.01). Moreover, it prolonged time spent open arms elevated plus maze 0.001). Concomitantly, stimulation proliferative activity hippocampal regions was seen (hilus p 0.01; subgranular zone 0.001) when compared DEP males. Additionally, number mature neurons CA1 region hippocampus increased markedly 0.01), indicating role maturation process neurons. Thus, points anxiolytic/antidepressant GA. However, future studies are needed this complex area.

Язык: Английский

The cytotoxic potential of polyphenols extracted from eight lichen species and their antioxidant activity against the cancer cell lines

Biocatalysis and Agricultural Biotechnology, Год журнала: 2024, Номер unknown, С. 103424 - 103424

Опубликована: Окт. 1, 2024

Язык: Английский