BioChem, Год журнала: 2025, Номер 5(2), С. 9 - 9
Опубликована: Апрель 25, 2025
Oral solid drug delivery continues to be the gold standard in pharmaceutical formulations, owing its cost-effectiveness, ease of administration, and high patient compliance. Tablets, most widely used dosage form, are favored for their precise dosing, simplicity, economic advantages. Among these, controlled release (CR) tablets stand out ability maintain consistent levels, enhance therapeutic efficacy, reduce dosing frequency, thereby improving adherence treatment outcomes. A well-designed CR system ensures a sustained targeted supply, optimizing performance while minimizing side effects. This review delves into latest advancements with particular focus on hydrophilic matrix systems, which regulate through mechanisms such as swelling, diffusion, erosion. These systems rely variety polymers drug-retarding agents achieve tailored profiles. Recent breakthroughs crystal engineering polymer science have further enhanced solubility bioavailability, addressing critical challenges associated poorly soluble drugs. In terms manufacturing, direct compression has emerged efficient method producing tablets, streamlining production ensuring release. The integration Quality by Design framework been instrumental product systematically linking formulation process variables patient-centric quality attributes. advent cutting-edge technologies artificial intelligence 3D printing is revolutionizing field formulations. AI enables predictive modeling data-driven optimization profiles, facilitates development personalized medicines highly customizable kinetics. innovations paving way more patient-specific therapies. However, regulatory hurdles, patent constraints, need robust vivo validation remain significant barriers widespread adoption these advanced technologies. succinct underscores synergistic traditional emerging strategies tablets. It highlights potential co-crystal particularly those produced via compression, improve adherence, deliver superior By bridging gap between established practices innovative approaches, this poised address unmet clinical needs advance future oral delivery.
Язык: Английский