Biotransformation Enzymes Involved in Pah and 6ppd-Q Metabolism in Gills and Liver of 3 Trout Species Exposed to Tire Rubber Particles

Опубликована: Янв. 1, 2025

As a subclass of microplastics, tire and road wear particles have been recognized as source toxicants in the aquatic environment. Tire rubber contains chemicals associated with serious toxicological effects, especially some salmonid species, but not other fish species. Among these are polynuclear aromatic hydrocarbons (PAHs) 6PPD-Q. These detoxified excreted through enzymatic biotransformation, notably by cytochrome P-450 (CYP) isoforms UDP-glucuronosyltransferases (UGT). We tested hypothesis that species differences activity enzymes is responsible for sensitivity to PAHs Three trout (rainbow trout, brook brown trout) were exposed 100-250 mg/L micronized 96h exposures, after which CYP1A was measured EROD assay, phenol-type UGT 1-naphthol both liver gill tissue. Bile fluorescence indicator uptake excretion PAHs. The results showed activities gills much lower than liver, would explain observed behavioral toxicity mortality this during exposure. In significantly upregulated rainbow gills. Comparison data from demonstrated relatively low expression, which, combined activity, supports PAH 6PPD-Q determined expression detoxification enzymes.

Язык: Английский

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High-resolution observation per 1.5 h revealed prominent time-dependent daily contamination variations of p-phenylenediamine (PPD) antioxidants and their quinone derivatives PPDQs in PM2.5 from central China

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 289, С. 117655 - 117655

Опубликована: Янв. 1, 2025

p-Phenylenediamine (PPD) antioxidants and their quinone derivatives (PPDQs), as hot-spot novel contaminants in recent years, have been detected air fine particulate matters (PM

Язык: Английский

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p-Phenylenediamines and their derived quinones: A review of their environmental fate, human exposure, and biological toxicity

Journal of Hazardous Materials, Год журнала: 2025, Номер 488, С. 137373 - 137373

Опубликована: Янв. 25, 2025

Язык: Английский

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Molecular insight on conformational alterations and functional changes of acetylcholinesterase induced by an emerging environmental pollutant 6PPD-quinone

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 305, С. 141205 - 141205

Опубликована: Фев. 17, 2025

Язык: Английский

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Subchronic and Acute Toxicity of 6PPD-Quinone to Early Life Stage Rainbow Trout (Oncorhynchus mykiss)

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) is a derivative of rubber tires which leaches into surface waters when tire particles are swept roadway runoff. 6PPD-Q has been identified as potential cause urban runoff mortality syndrome in coho salmon, and subsequent research determined wide variation toxicity among fishes. While adult rainbow trout known to be sensitive, there limited on the response early life stages exposure. Given that fish often more sensitive than adults, aim these studies was assess acute subchronic stage trout. Rainbow alevins were exposed from hatch until 28 days post-hatch time-weighted average concentrations ranging 0.06 2.35 μg/L, 28-day median lethal dose (LC50) 0.56 well morphological deformities, including pooling blood caudal fin. A follow-up study with exogenously feeding fry revealed 96-h LC50 0.47 μg/L. These indicate exposure, underscore importance utilizing determine most benchmark concentrations, their value determining sublethal effects.

Язык: Английский

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Emergence of More Potent PPD-Qs beyond 6PPD-Q in Human Blood and Cerebrospinal Fluid

Environmental Science & Technology Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Язык: Английский

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Environmental Fate, Toxicity, and Mitigation of 6PPD and 6PPD-Quinone: Current Understanding and Future Directions

Environmental Pollution, Год журнала: 2025, Номер 375, С. 126352 - 126352

Опубликована: Май 1, 2025

Язык: Английский

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Chronic Toxicity Mechanisms of 6PPD and 6PPD-Quinone in Zebrafish

Environmental Science and Ecotechnology, Год журнала: 2025, Номер unknown, С. 100567 - 100567

Опубликована: Май 1, 2025

Язык: Английский

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p-phenylenediamines (PPDs) and PPD-quinones (PPD-Qs) in human urine and breast milk samples: Urgent need for focus on PPD-Qs and the establishment of health threshold criteria

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136176 - 136176

Опубликована: Окт. 15, 2024

Язык: Английский

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Environmental occurrence, fate, human exposure, and human health risks of p-phenylenediamines and their quinones

The Science of The Total Environment, Год журнала: 2024, Номер 957, С. 177742 - 177742

Опубликована: Ноя. 29, 2024

Язык: Английский

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