Abstract
Numerous
organisms
in
nature
have
demonstrated
enhanced
biocompatibility,
precise
tumor
targeting
capabilities,
and
efficient
tissue
traversal
within
the
human
body.
Drawing
inspiration
from
these
organisms,
researchers
employed
bioengineering,
bioconjugation,
micro‐
or
nanotechnology
to
fabricate
bioinspired
nanostructured
systems.
These
systems
play
a
crucial
role
addressing
limitations
of
conventional
anticancer
drugs
nanomaterials
concerning
effective
penetration
physiological
barriers,
as
well
selective
targeting,
thereby
leading
improved
therapeutic
efficacy
while
minimizing
nonspecific
adverse
effects
on
healthy
cells.
Consequently,
extensive
exploration
has
been
undertaken
across
various
cancer
treatment
modalities
with
some
progressing
into
preclinical
clinical
stages.
However,
our
understanding
this
field
remains
limited
which
may
impede
research
progress,
translation
efforts,
practical
applications.
Therefore,
study
presents
systematic
classification
for
therapy
that
comprehensively
elucidates
their
sources
design
principles.
Furthermore,
it
extensively
discusses
current
status
efforts
identifying
prevailing
challenges
exploring
future
prospects.
This
work
will
establish
robust
theoretical
framework
serve
valuable
reference
facilitate
advancements
application
field.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Фев. 20, 2025
The
progression
of
malignant
tumors
leads
to
the
development
secondary
in
various
organs,
including
bones,
brain,
liver,
and
lungs.
This
metastatic
process
severely
impacts
prognosis
patients,
significantly
affecting
their
quality
life
survival
rates.
Research
efforts
have
consistently
focused
on
intricate
mechanisms
underlying
this
corresponding
clinical
management
strategies.
Consequently,
a
comprehensive
understanding
biological
foundations
tumor
metastasis,
identification
pivotal
signaling
pathways,
systematic
evaluation
existing
emerging
therapeutic
strategies
are
paramount
enhancing
overall
diagnostic
treatment
capabilities
for
tumors.
However,
current
research
is
primarily
metastasis
within
specific
cancer
types,
leaving
significant
gaps
our
complex
cascade,
organ-specific
tropism
mechanisms,
targeted
treatments.
In
study,
we
examine
sequential
processes
elucidate
driving
organ-tropic
systematically
analyze
tumors,
those
tailored
organ
involvement.
Subsequently,
synthesize
most
recent
advances
technologies
challenges
opportunities
encountered
pertaining
bone
metastasis.
Our
objective
offer
insights
that
can
inform
future
practice
crucial
field.
Biomimetics,
Год журнала:
2025,
Номер
10(2), С. 73 - 73
Опубликована: Янв. 24, 2025
The
gut
microbiota
is
a
complex
and
dynamic
ecosystem
that
plays
fundamental
role
in
human
health
by
regulating
immunity,
metabolism,
the
gut–brain
axis.
Beyond
its
critical
physiological
functions,
it
has
emerged
as
rich
source
of
inspiration
for
biomimetic
innovations
healthcare
biotechnology.
This
review
explores
transformative
potential
microbiota-based
biomimetics,
focusing
on
key
biological
mechanisms
such
resilience,
self-regulation,
quorum
sensing.
These
have
inspired
development
innovative
applications,
including
personalized
probiotics,
synbiotics,
artificial
microbiomes,
bioinspired
biosensors,
bioremediation
systems.
Such
technologies
aim
to
emulate
optimize
intricate
functions
microbial
ecosystems,
addressing
challenges
environmental
sustainability.
integration
advanced
technologies,
intelligence,
bioengineering,
multi-omics
approaches,
further
accelerated
biomimetics.
tools
enable
precision
therapies
tailored
individual
profiles,
enhance
efficacy
diagnostic
systems,
facilitate
design
environmentally
sustainable
solutions,
waste-to-energy
systems
platforms.
Emerging
areas
innovation,
gut-on-chip
models
synthetic
biology,
offer
unprecedented
opportunities
studying
applying
principles
controlled
environments.
Despite
these
advancements,
remain.
replication
complexity
environments,
ethical
concerns
regarding
genetically
engineered
microorganisms,
equitable
access
are
hurdles
must
be
addressed.
underscores
importance
interdisciplinary
collaboration
public
awareness
overcoming
barriers
ensuring
responsible
solutions.
By
leveraging
biomimetics
represents
promising
frontier
approach
revolutionize
therapeutic
strategies,
redefine
tools,
address
global
challenges,
paving
way
more
personalized,
efficient,
future
medicine
Microbiology Spectrum,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
ABSTRACT
Colorectal
cancer
(CRC)
is
a
common
accompanied
by
microbiome
dysbiosis.
Exploration
of
probiotics
against
oncogenic
microorganisms
promising
for
CRC
treatment.
Here,
differential
between
and
healthy
control
were
analyzed.
Antibacterial
experiments,
whole-genome
sequencing,
metabolic
network
reconstruction
combined
to
reveal
the
anti-
Fusobacterium
nucleatum
mechanism,
which
was
verified
co-culture
assay
mendelian
randomization
analysis.
Sequencing
results
showed
that
F.
enriched
in
CRC,
yet
Bifidobacterium
animalis
decreased
gradually
from
CRC.
Additionally,
could
be
inhibited
B.
.
Whole-genome
sequencing
high
phylogenetic
similarity
with
known
probiotic
strains
highlighted
its
functions
amino
acid
carbohydrate
metabolism.
Metabolic
demonstrated
cross-feeding
specific
metabolites
(acidic
molecules,
arginine)
had
great
influence
on
coexistence
relationship.
Finally,
arginine
supplement
enhanced
competitive
ability
,
metagenomic
analysis
confirmed
positive
relationship
among
metabolism,
Thus,
are
valuable
mining
patient
dietary
guidance.
IMPORTANCE
Using
inhibit
(
)
colorectal
In
this
study,
mechanism
The
result
indicated
may
harmful
-infected
patients.
potential
relieve
dilemma.
using
silico
simulation
methods
based
flux
balance
analysis,
such
as
genome-scale
reconstruction,
provides
insights
guidance
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
Single-atom
nanozymes
are
highly
effective
in
the
preparation
of
tumor
vaccines
(TV)
due
to
their
superior
peroxidase
(POD)
activity
and
excellent
biocompatibility.
However,
immunosuppressive
environment
within
tumors
can
diminish
efficacy
these
vaccines.
Cold
exposure
(CE)
therapy,
a
noninvasive
straightforward
antitumor
method,
not
only
suppresses
metabolism
but
also
ameliorates
milieu.
In
this
study,
we
developed
personalized
TV
using
copper
single-atom
nanozyme
(Cu
SAZ)
enhanced
long-term
by
introducing
CE.
We
initially
synthesized
Cu
SAZ
via
high-temperature
carbonization,
which
demonstrated
robust
POD
photothermal
characteristics.
Upon
808
nm
laser
irradiation,
generated
reactive
oxygen
species
(ROS)
heat,
inducing
immunogenic
cell
death
4T1
breast
cancer
cells
or
CT26
colon
facilitating
production.
our
vivo
prevention
treatment
model,
noted
that
CE
significantly
boosted
TV.
The
primary
mechanism
involves
CE's
ability
lower
ratio
myeloid-derived
suppressor
(MDSCs),
decrease
glucose
cells,
increase
proportions
CD8+
T
memory
cells.
Collectively,
findings
offer
promising
avenues
for
designing
innovative
systems.
Specific
bacteria,
including
Fusobacterium
nucleatum
,
Streptococcus
sanguis
Enterococcus
faecalis
and
Staphylococcus
xylosus
have
been
identified
as
contributors
to
breast
cancer
metastasis.
Due
limitations
such
lack
of
selectivity,
traditional
antibiotic
therapies
face
obstacles
in
eliminating
intratumoral
bacteria.
Herein,
this
work
proposes
the
use
therapeutic
vaccines
selectively
target
eliminate
harmful
bacteria
within
tumors.
A
multivalent
vaccine
encapsulating
both
insoluble
soluble
bacterial
antigens
was
developed,
addressing
shortcomings
antibacterial
by
balancing
broad
antigen
coverage
with
effective
immune
activation.
This
induces
robust
downstream
responses
F.
S.
E.
demonstrating
notable
preventive
efficacy
bacteria-induced
metastasis
models.
Unexpectedly,
vaccinated
infected
mice
showed
even
slower
tumor
than
uninfected
mice.
Overall,
study
validates
potential
nanovaccines
modulating
microbiome
for
therapy
highlights
tumor-associated
infections
promising
antitumor
targets.
