Environment International,
Год журнала:
2019,
Номер
127, С. 592 - 600
Опубликована: Апрель 12, 2019
Little
information
is
available
on
the
content
of
bisphenol
A
(BPA)
and
other
endocrine-disrupting
chemicals
(EDCs)
such
as
parabens
in
infant
textiles
clothes.1)
To
determine
concentrations
BPA
socks
for
infants
young
children
purchased
Spain,
2)
to
assess
(anti-)estrogenicity
(anti-)androgenicity
extracts
from
socks,
3)
estimate
dermal
exposure
doses
these
chemicals.Thirty-two
pairs
(1-48
months)
were
3
stores
Granada
(Spain).
Textile
material
was
cut
foot,
toe,
leg
each
sock
(n
=
96
samples)
chemical
analysis.
Hormone-like
activities
determined
foot
sections
32
by
using
E-Screen
assay
PALM
luciferase
(anti-)androgenicity.BPA
present
90.6%
samples
at
ranging
<0.70
3736
ng/g.
levels
around
25-fold
higher
store
1,
which
had
a
cotton
compared
2
3.
Ethyl-paraben
found
100%
samples,
followed
methyl-paraben
(81.0%),
propyl-paraben
(43.7%).
No
butyl-paraben
detected
any
sample.
Estrogenic
activity
83.3%
1
(range
48.2-6051
pM
E2eq/g)
but
only
three
Anti-androgenic
six
studied
94.4-2989
μM
Proceq/g),
all
1.
Estimated
aged
36-48
months
(median
17.6
pg/kg/day),
24-36
0.60
pg/kg/day).This
first
report
Europe
wide
presence
marketed
children.
appears
contribute
hormone-like
observed
extracts.
Toxicological Sciences,
Год журнала:
2019,
Номер
172(2), С. 303 - 315
Опубликована: Сен. 14, 2019
Abstract
This
study
was
performed
to
examine
the
transgenerational
effects
of
bisphenol
(BP)
A
analogs,
BPE,
and
BPS
on
male
reproductive
functions
using
mice
as
a
model.
CD-1
(F0)
were
orally
exposed
control
treatment
(corn
oil),
BPA,
or
(0.5
50
µg/kg/day)
from
gestational
day
7
(the
presence
vaginal
plug
=
1)
birth.
Mice
F1
F2
offspring
used
generate
F3
males.
Prenatal
exposure
decreased
sperm
counts
and/or
motility
disrupted
progression
germ
cell
development
morphometric
analyses
exhibited
an
abnormal
distribution
stages
spermatogenesis
in
Dysregulated
serum
levels
estradiol-17β
testosterone,
well
expression
steroidogenic
enzymes
adult
testis
also
observed.
In
neonatal
testis,
although
apoptosis
DNA
damage
not
affected,
mRNA
methyltransferases,
histone
their
associated
factors
increased
by
BP
exposure.
Furthermore,
induced
immunoreactive
DNMT3A
Sertoli
cells,
strengthened
DNMT3B,
weakened
H3K9me2
H3K9me3
cells
whereas
DNMT1,
H3K4me3,
H3K27ac
affected.
stage-specific
DNMT3B
altered
exposure,
DNMT3A,
H3K9me2,
remained
stable.
These
results
suggest
that
prenatal
induces
probably
due
epigenetic
modification
following
disruption
DNMTs
marks
testis.
