Assessing the ecological impact of chemical pollution on aquatic ecosystems requires the systematic exploration and evaluation of four lines of evidence DOI Creative Commons
Thomas Backhaus, Werner Brack, Paul J. Van den Brink

и другие.

Environmental Sciences Europe, Год журнала: 2019, Номер 31(1)

Опубликована: Дек. 1, 2019

Abstract The aim of the European Water Framework Directive is to ensure good ecological status for all surface waters. However, although current monitoring strategies identify presence and magnitude impacts, they provide little information on causes an ecosystem impairment. In fact, approaches establish causal links between chemical pollution impacts exposed aquatic systems are largely lacking or poorly described established. This is, however, crucial developing implementing appropriately targeted water management strategies. order role ecosystem, we suggest systematically combine four lines evidence (LOEs) that complementary potential impact complex pollution: (1) component-based methods allow a predictive mixture risk modeling; (2) effect-based methods; (3) in situ tests; (4) field-derived species inventories. These LOEs differ their specificity pollution, data demands, resources required relevance. They complement each other and, combination, assess contribution pressure structure function. Data from not always available necessarily consistent. We therefore propose systematic, robust transparent approach given study, consensual conclusions drawn dataset. allows critical gaps needs future testing and/or options efficient management.

Язык: Английский

Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive DOI
Beate I. Escher,

Selim Aїt‐Aїssa,

Peter Behnisch

и другие.

The Science of The Total Environment, Год журнала: 2018, Номер 628-629, С. 748 - 765

Опубликована: Фев. 20, 2018

Язык: Английский

Процитировано

218
Future water quality monitoring: improving the balance between exposure and toxicity assessments of real-world pollutant mixtures DOI Creative Commons
Rolf Altenburger, Werner Brack, Robert M. Burgess

и другие.

Environmental Sciences Europe, Год журнала: 2019, Номер 31(1)

Опубликована: Фев. 19, 2019

Environmental water quality monitoring aims to provide the data required for safeguarding environment against adverse biological effects from multiple chemical contamination arising anthropogenic diffuse emissions and point sources. Here, we integrate experience of international EU-funded project SOLUTIONS shift focus a few legacy chemicals complex mixtures, identify relevant drivers toxic effects. Monitoring serves range purposes, control ecological status compliance specific uses, such as drinking abstraction. Various sampling techniques, target, suspect non-target analyses well an array in vitro, vivo situ bioanalytical methods were advanced improve contamination. Major improvements broader applicability include tailored screening identification techniques more diverse set chemicals, higher detection sensitivity, standardized protocols chemical, toxicological, assessments combined with systematic evidence evaluation techniques. No single method or combination is able meet all divergent purposes. Current approaches tend emphasize either targeted exposure effect detection. argue that, irrespective purpose, assessment results would benefit substantially obtaining linking information on occurrence both potentially In this paper, specify to: (1) contaminants, (2) assess impact aquatic ecosystems, (3) quantify cause–effect relationships between contaminants Specific strategies link are outlined each these distinct goals. These have been developed explored using case studies Danube Rhine river basins rivers Iberian Peninsula. suffers biases resulting differences associated uncertainty analyses. While ignore gaps (i.e., missing contaminants), effect-based penalize increased factors. This integrated work suggests ways deal mixture exposures balanced way, thus provides guidance future environmental monitoring.

Язык: Английский

Процитировано

217
The advantages of linear concentration–response curves for in vitro bioassays with environmental samples DOI
Beate I. Escher, Peta A. Neale, Daniel L. Villeneuve

и другие.

Environmental Toxicology and Chemistry, Год журнала: 2018, Номер 37(9), С. 2273 - 2280

Опубликована: Май 30, 2018

Abstract In vitro assays and high‐throughput screening (HTS) tools are increasingly being employed as replacements for animal testing, but most concentration–response curves still evaluated with models developed testing. We argue that application of in assays, particularly reporter gene to environmental samples can benefit from a different approach modeling. First, cytotoxicity often occurs at higher concentrations, especially weakly acting compounds complex mixtures many components. these cases, specific effects be masked by cytotoxicity. Second, HTS low effect levels precisely quantified because the variability controls cell‐based opportunity run concentrations replicates when using high‐density well‐plate formats (e.g., 384 or more wells per plate). Hence, we recommend focusing modeling on lower portion curve, which is approximately linear. Effect derived low–effect level linear facilitate simple derivation relative potencies correct mixture toxicity calculation bioanalytical equivalent concentrations. Environ Toxicol Chem 2018;37:2273–2280. © 2018 SETAC

Язык: Английский

Процитировано

107
Towards a holistic and solution-oriented monitoring of chemical status of European water bodies: how to support the EU strategy for a non-toxic environment? DOI Creative Commons
Werner Brack, Beate I. Escher, E. Müller

и другие.

Environmental Sciences Europe, Год журнала: 2018, Номер 30(1)

Опубликована: Сен. 4, 2018

The definition of priority substances (PS) according to the Water Framework Directive (WFD) helped remove many these chemicals from market and reduce their concentrations in European water bodies. However, it could not prevent that have been replaced by others with similar risks. Today, monitoring PS-based chemical status WFD covers only a tiny fraction toxic risks, extensively ignores mixture effects lacks incentives guidance for abatement. Thus, we suggest complement this purely status-related approach more holistic solution-oriented monitoring, which at same time helps provide links ecological status. Major elements include (1) advanced screening techniques supporting risk assessment unraveling source-related patterns complex mixtures, (2) effect-based detection groups establishment toxicity fingerprints, (3) effect-directed analysis drivers (4) translate toxicological fingerprints into footprints prioritization management measures. requirement contamination is supported significant advancement appropriate tools within last years. Non-target technology, basic understanding are available conceptually research but also increasingly find way practical monitoring. Substantial progress development, evaluation demonstration tools, example, SOLUTIONS project enhanced acceptability. Further advancement, integration demonstration, extensive data exchange closure remaining knowledge gaps suggested as high needs next future bridge gap between insufficient cost-efficient abatement

Язык: Английский

Процитировано

86
Occurrence and assessment of environmental risks of endocrine disrupting compounds in drinking, surface and wastewaters in Serbia DOI
Mira Čelić, Biljana Škrbić, Sara Insa

и другие.

Environmental Pollution, Год журнала: 2020, Номер 262, С. 114344 - 114344

Опубликована: Март 11, 2020

Язык: Английский

Процитировано

83
Advances in suspect screening and non-target analysis of polar emerging contaminants in the environmental monitoring DOI
Monika Paszkiewicz, Klaudia Godlewska, Hanna Lis

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2022, Номер 154, С. 116671 - 116671

Опубликована: Май 9, 2022

Язык: Английский

Процитировано

67
Effect-Directed Analysis Combined with Nontarget Screening to Identify Unmonitored Toxic Substances in the Environment DOI Creative Commons
Seongjin Hong, Jung‐Hyun Lee, Jihyun Cha

и другие.

Environmental Science & Technology, Год журнала: 2023, Номер 57(48), С. 19148 - 19155

Опубликована: Ноя. 16, 2023

Effect-directed analysis (EDA) combined with nontarget screening (NTS) has established a valuable tool for the identification of unmonitored toxic substances in environmental samples. It consists three main steps: (1) highly potent fraction identification, (2) toxicant candidate selection, and (3) major identification. Here, we discuss methodology, current status, limitations, future challenges EDA NTS. This method been applied successfully to various samples, such as sediments, wastewater treatment plant effluents, biota. We present several case studies highlight key results. undergone significant technological advancements past 20 years, establishment its components: target chemical analysis, bioassays, fractionation, NTS, data processing. However, it not incorporated widely into monitoring programs. provide suggestions application NTS programs management, further research needs.

Язык: Английский

Процитировано

24
Progress, applications, and challenges in high-throughput effect-directed analysis for toxicity driver identification — is it time for HT-EDA? DOI Creative Commons
Iker Alvarez-Mora, Katarzyna Arturi, Frederic Béen

и другие.

Analytical and Bioanalytical Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Июль 12, 2024

Abstract The rapid increase in the production and global use of chemicals their mixtures has raised concerns about potential impact on human environmental health. With advances analytical techniques, particular, high-resolution mass spectrometry (HRMS), thousands compounds transformation products with adverse effects can now be detected samples. However, identifying prioritizing toxicity drivers among these remain a significant challenge. Effect-directed analysis (EDA) emerged as an important tool to address this challenge, combining biotesting, sample fractionation, chemical unravel complex mixtures. Traditional EDA workflows are labor-intensive time-consuming, hindering large-scale applications. concept high-throughput (HT) recently gained traction means accelerating workflows. Key features HT-EDA include combination microfractionation downscaled bioassays, automation preparation efficient data processing supported by novel computational tools. In addition microplate-based high-performance thin-layer chromatography (HPTLC) offers interesting alternative HPLC HT-EDA. This review provides updated perspective state-of-the-art HT-EDA, methods/tools that incorporated into It also discusses recent studies HT prioritization tools, along considerations regarding HPTLC. By current gaps proposing new approaches overcome them, aims bring step closer monitoring Graphical

Язык: Английский

Процитировано

10
Occurrence and potential risk of steroid hormones in selected surface water and wastewater treatment plants in western Kenya DOI Creative Commons

Isaac Cheruiyot Tanui,

Faith Jebiwot Kandie, Martin Krauß

и другие.

Environmental Pollution, Год журнала: 2025, Номер 367, С. 125623 - 125623

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Opinion paper about organic trace pollutants in wastewater: Toxicity assessment in a European perspective DOI
Roberta Pedrazzani, Giorgio Bertanza, Ivan Brnardić

и другие.

The Science of The Total Environment, Год журнала: 2018, Номер 651, С. 3202 - 3221

Опубликована: Окт. 5, 2018

Язык: Английский

Процитировано

68