Molecules,
Год журнала:
2021,
Номер
26(9), С. 2811 - 2811
Опубликована: Май 10, 2021
In
the
late
1930s
and
early
1940s,
it
was
discovered
that
substitution
on
aromatic
rings
of
hydrogen
atoms
with
chlorine
yielded
a
novel
chemistry
antimicrobials.
However,
within
few
years,
many
these
compounds
formulations
showed
adverse
effects,
including
human
toxicity,
ecotoxicity,
unwanted
environmental
persistence
bioaccumulation,
quickly
leading
to
regulatory
bans
phase-outs.
Among
these,
triclocarban,
polychlorinated
antimicrobial
agent,
employed
as
major
ingredient
toys,
clothing,
food
packaging
materials,
industry
floors,
medical
supplies,
especially
personal
care
products,
such
soaps,
toothpaste,
shampoo.
Triclocarban
has
been
widely
used
for
over
50
but
only
recently
some
concerns
were
raised
about
its
endocrine
disruptive
properties.
September
2016,
U.S.
Food
Drug
Administration
banned
use
in
over-the-counter
hand
body
washes
because
toxicity.
The
withdrawal
triclocarban
prompted
efforts
search
new
several
analogues
have
also
studied.
this
review,
an
examination
different
facets
will
be
analyzed.
Environmental Science & Technology,
Год журнала:
2021,
Номер
55(17), С. 11874 - 11884
Опубликована: Авг. 17, 2021
Benzotriazole
ultraviolet
stabilizers
(BUVSs)
are
high-production-volume
chemicals
with
ubiquitous
occurrence
in
the
aquatic
environment.
However,
little
is
known
about
their
bioconcentration
and
biotransformation,
physiologically
based
toxicokinetic
(PBTK)
models
for
BUVSs
lacking.
This
study
selected
six
which
experiments
were
performed
zebrafish
(Danio
rerio)
exposed
to
two
different
levels
(0.5
10
μg·L–1).
Higher
kinetic
factors
(BCFs)
observed
at
lower
exposure
level
environmental
relevance,
BCF
of
3.33
×
103
L·kg–1
2-(2-hydroxy-3,5-di-tert-butylphenyl)-5-chlorobenzotriazole
(UV-327).
phenomenon
was
interpreted
by
a
nonlinear
adsorption
mechanism,
where
binding
specific
protein
sites
contributes
bioconcentration.
Muscle
exhibited
lowest
accumulation,
depuration
half-life
UV-327
19.5
d.
In
kidney,
muscle,
ovary,
gill,
skin,
logBCF
increased
increase
log
KOW
until
ca.
6.5,
above
decreased.
trend
not
liver
intestine.
Six
biotransformation
products
identified
mainly
accumulated
Considering
mechanism
PBTK
model,
prediction
accuracy
model
improved,
highlighting
xenobiotics
assessing
risk
assessment.
Environmental Science & Technology,
Год журнала:
2022,
Номер
56(8), С. 5009 - 5019
Опубликована: Апрель 8, 2022
Ultraviolet
absorbents
(UVAs)
and
industrial
antioxidants
(IAs)
are
contaminants
of
emerging
concern.
In
this
study,
we
investigated
the
distribution
partitioning
these
in
surface
water,
suspended
particulate
matter
(SPM),
sediment,
various
tissues
lake
sturgeon
(Acipenser
fulvescens)
northern
pike
(Esox
lucius)
from
St.
Lawrence
River
(SLR),
Quebec,
Canada.
Results
indicated
that
2,6-di-tert-butyl-1,4-benzoquinone
(BHTQ)
was
dominant
contaminant
dissolved
phase
with
median
concentrations
43,
15,
123
ng/L
for
three
sampling
sites,
respectively.
Surface
water
collected
downstream
a
major
city
showed
higher
levels
UVAs,
BHTQ,
diphenylamine
compared
to
upstream,
suggesting
influence
urban
activities
on
contamination
SLR.
SPM
greater
sorption
capacities
most
target
those
sediment.
Different
profiles
were
found
pike,
implying
accumulation
UVAs
IAs
fish
depends
their
feeding
behavior.
The
field-based
tissue-specific
bioaccumulation
factors
(BAFs)
frequently
detected
(log
BAF
1.5-4.2)
generally
comparable
or
lower
than
Estimation
Program
Interface
modeling
results
(1.4-5.0),
indicating
some
may
be
less
bioaccumulative
previously
expected.
