Associations of essential trace metals with telomere length in general population: a cross-sectional study

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 11, 2025

This study investigated the relationship between essential plasma metals (Co, Cr, Cu, Mn, Mo, Se, Zn) and telomere length in 2,194 Chinese adults aged ≥ 30 years. Metal concentrations were measured using ICP-MS, leukocyte relative (rTL) was assessed by qPCR. In elderly, Cr Mn significantly positively correlated with rTL, while Zn, Cu showed negative correlations. 30–59 age group, overall metal mixture negatively associated rTL (estimate = -0.069, P 0.003), Zn as dominant contributor. 0.040, 0.031), main contributors. The findings highlight importance of maintaining adequate levels older adults, potential adverse impact on length.

Язык: Английский

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Association between multiple metals mixture and diabetic retinopathy in older adults with diabetes mellitus: a cross-sectional study in China

Environmental Geochemistry and Health, Год журнала: 2025, Номер 47(5)

Опубликована: Апрель 1, 2025

Язык: Английский

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Antimony induces mitochondria-dependent and ER stress-triggered apoptosis via the oxidative stress-activated JNK signaling pathway in pancreatic islet β-cells

Toxicology, Год журнала: 2025, Номер unknown, С. 154188 - 154188

Опубликована: Май 1, 2025

Язык: Английский

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Identifying Effects of Urinary Metals on Type 2 Diabetes in U.S. Adults: Cross-Sectional Analysis of National Health and Nutrition Examination Survey 2011–2016

Nutrients, Год журнала: 2022, Номер 14(8), С. 1552 - 1552

Опубликована: Апрель 8, 2022

Growing evidence supports the associations of metal exposures with risk type 2 diabetes (T2D), but methodological limitations overlook complexity relationships within mixtures. We identified and estimated single combined effects urinary metals their interactions prevalence T2D among 3078 participants in NHANES 2011-2016. analyzed 15 eight by elastic-net regression model for further analysis T2D. Bayesian kernel machine weighted quantile sum (WQS) models four that had greater importance T2D, namely cobalt (Co), tin (Sn), uranium (U) strontium (Sr). The overall OR was 1.05 (95% CI: 1.01-1.08) positive 1.00 0.98-1.02) negative effect WQS models. observed (

Язык: Английский

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Joint effects of per- and polyfluoroalkyl substance alternatives and heavy metals on renal health: A community-based population study in China

Environmental Research, Год журнала: 2022, Номер 219, С. 115057 - 115057

Опубликована: Дек. 15, 2022

Язык: Английский

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Sex- and age-specific associations of serum essential elements with diabetes among the Chinese adults: a community-based cross-sectional study

Nutrition & Metabolism, Год журнала: 2024, Номер 21(1)

Опубликована: Июль 9, 2024

Abstract Background Although several studies have found the relationship between essential elements and diabetes, about association of with diabetes diagnosed according to an oral glucose tolerance test (OGTT) glycated hemoglobin (HbA1c) in a sex- age-specific manner were limited. To investigate linear nonlinear five including iron (Fe), copper (Cu), Zinc (Zn), magnesium (Mg), calcium (Ca) fasting plasma (FPG), 2-h postprandial (PPG), HbA1c evaluate heterogeneities these relationships. Methods A total 8392 community-dwelling adults recruited complete questionnaire undergo checkups anthropometric parameters serum levels metals (Fe, Cu, Zn, Mg, Ca). The multivariable logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis applied find associations prevalence as well FPG, PPG, HbA1c. Results In regression Cu was positively associated while Mg significantly inversely correlated HbA1c, (all P < 0.001). RCS non-linear ( 0.001) found. stronger positive for interaction = 0.027) PPG 0.002) younger women. Conclusions These findings may lead more appropriate approaches supplementation people different ages sexes. However, prospective cohort experimental are needed probe possible mechanism diabetes.

Язык: Английский

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Correlation between urinary contents of some metals and fasting plasma glucose levels: A cross-sectional study in China

Ecotoxicology and Environmental Safety, Год журнала: 2021, Номер 228, С. 112976 - 112976

Опубликована: Ноя. 12, 2021

Many metals are involved in the pathogenesis of diabetes, but most existing studies focused on single metals. The study mixtures represents real-life exposure scenarios and deserves attention. This aimed to explore potential relationship urinary copper (Cu), zinc (Zn), arsenic (As), selenium (Se), strontium (Sr) contents with fasting plasma glucose (FPG) levels 2766 participants. urine were determined by inductively coupled plasma–mass spectrometry. We used linear regression models Bayesian kernel machine (BKMR) evaluate association between FPG levels. In multiple regression, Zn (β = 0.434), Se 0.172), Sr −0.143) showed significant (all P < 0.05). BKMR model analysis that results metal consistent regression. mixture five had a positive over-all effect levels, (PIP 1.000) contributed Cu As negatively correlated women. interaction was observed participants aged ≥ 60 years old (Pinteraction 0.035). summary, our suggested associated Further needed confirm these findings clarify underlying mechanisms.

Язык: Английский

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Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China

Journal of Diabetes Investigation, Год журнала: 2022, Номер 13(8), С. 1412 - 1425

Опубликована: Март 27, 2022

Metals play an important role in diabetes mellitus. This cross-sectional study aimed to evaluate the overall, individual and interactive effects of multi-metal exposure on prevalence mellitus, impaired fasting glucose (IFG) rate blood (FBG) levels.

Язык: Английский

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Exposure to multiple metals and diabetes mellitus risk in dong ethnicity in China: from the China multi-ethnic cohort study

Environmental Geochemistry and Health, Год журнала: 2022, Номер 45(5), С. 2435 - 2445

Опубликована: Авг. 20, 2022

Язык: Английский

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Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 256, С. 114852 - 114852

Опубликована: Апрель 5, 2023

Antimony (Sb) poses a significant threat to human health due sharp increases in its exploitation and application globally, but few studies have explored the pathophysiological mechanisms of acute hepatotoxicity induced by Sb exposure. We established an vivo model comprehensively explore endogenous underlying liver injury short-term Adult female male Sprague-Dawley rats were orally administrated various concentrations potassium antimony tartrate for 28 days. After exposure, serum concentration, liver-to-body weight ratio, glucose levels significantly increased dose-dependent manner. Body gain biomarkers hepatic (e.g., total cholesterol, protein, alkaline phosphatase, aspartate aminotransferase/alanine aminotransferase ratio) decreased with increasing Through integrative non-targeted metabolome lipidome analyses, alanine, aspartate, glutamate metabolism; phosphatidylcholines; sphingomyelins; phosphatidylinositols most affected pathways exposed Sb. Additionally, correlation analysis showed that certain metabolites lipids deoxycholic acid, N-methylproline, palmitoylcarnitine, glycerophospholipids, sphingomyelins, glycerol) associated biomarkers, indicating metabolic remodeling may be involved apical hepatotoxicity. Our study demonstrated exposure induces hepatotoxicity, possibly through glycolipid metabolism disorder, providing important reference risks pollution.

Язык: Английский

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