Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(7), С. 3121 - 3143
Опубликована: Май 30, 2024
Environmental
impacts
of
the
industrial
revolution
necessitate
adoption
sustainable
practices
in
all
areas
development.
The
pharmaceutical
industry
faces
increasing
pressure
to
minimize
its
ecological
footprint
due
significant
contribution
environmental
pollution.
Over
past
two
decades,
cocrystals
have
received
immense
popularity
their
ability
optimize
critical
attributes
active
ingredients
and
presented
an
avenue
bring
improved
drug
products
market.
This
review
explores
potential
as
ecofriendly
alternative
traditional
solid
forms,
offering
a
approach
From
reducing
number
required
doses
improving
stability
actives,
from
eliminating
synthetic
operations
using
pharmaceutically
approved
chemicals,
use
continuous
solvent-free
manufacturing
methods
leveraging
published
data
on
safety
toxicology,
cocrystallization
contributes
sustainability
latest
trends
suggest
promising
role
bringing
novel
medicines
market,
which
has
been
further
fuelled
by
recent
guidance
major
regulatory
agencies.
Antibiotics,
Год журнала:
2023,
Номер
12(4), С. 724 - 724
Опубликована: Апрель 7, 2023
Antimicrobial
resistance
(AMR)
is
one
of
the
world's
industrialized
nations'
biggest
issues.
It
has
a
significant
influence
on
ecosystem
and
negatively
affects
human
health.
The
overuse
antibiotics
in
healthcare
agri-food
industries
historically
been
defined
as
leading
factor,
although
use
antimicrobial-containing
personal
care
products
plays
role
spread
AMR.
Lotions,
creams,
shampoos,
soaps,
shower
gels,
toothpaste,
fragrances,
other
items
are
used
for
everyday
grooming
hygiene.
However,
addition
to
primary
ingredients,
additives
included
help
preserve
product
by
lowering
its
microbial
load
provide
disinfection
properties.
These
same
substances
released
into
environment,
escaping
traditional
wastewater
treatment
methods
remaining
ecosystems
where
they
contact
communities
promote
resistance.
study
antimicrobial
compounds,
which
often
solely
researched
from
toxicological
point
view,
must
be
resumed
considering
recent
discoveries,
highlight
their
contribution
Parabens,
triclocarban,
triclosan
among
most
worrying
chemicals.
To
investigate
this
issue,
more
effective
models
chosen.
Among
them,
zebrafish
crucial
system
because
it
allows
assessment
both
risks
associated
with
exposure
these
well
environmental
monitoring.
Furthermore,
artificial
intelligence-based
computer
systems
useful
simplifying
handling
antibiotic
data
speeding
up
drug
discovery
processes.
Environment International,
Год журнала:
2024,
Номер
183, С. 108433 - 108433
Опубликована: Янв. 1, 2024
Pregnant
women
are
exposed
to
numerous
endocrine
disrupting
chemicals
(EDCs)
that
can
affect
hormonal
pathways
regulating
pregnancy
outcomes
and
fetal
development.
Thus,
we
evaluated
overall
sex-specific
associations
of
phthalate/replacement,
paraben,
phenol
biomarkers
with
sex-steroid
thyroid
hormones.
Illinois
(n=302)
provided
plasma
for
progesterone,
estradiol,
testosterone,
free
T4
(FT4),
total
(TT4),
stimulating
hormone
(TSH)
at
median
17
weeks
gestation.
Women
also
up-to-five
first-morning
urine
samples
monthly
across
(8-40
weeks),
which
pooled
measure
19
phthalate/replacement
metabolites
(reflecting
ten
parent
compounds),
three
parabens,
six
phenols.
We
used
linear
regression
evaluate
hormones,
as
well
weighted
quantile
sum
Bayesian
kernel
machine
(BKMR)
assess
cumulative
associations,
non-linearities,
chemical
interactions.
In
relatively
high
socioeconomic
status,
several
EDC
were
associated
select
without
or
non-linear
FT4,
TT4.
The
biomarker
mixture
was
negatively
estradiol
(only
higher
concentrations
using
BKMR),
TSH,
where
each
10%
increase
-5.65%
(95%C.I.:
-9.79,
-1.28)
lower
testosterone
-0.09
μIU/mL
(95%CI:
-0.20,
0.00)
TSH.
Associations
FT4
did
not
differ
by
sex.
However,
in
carrying
females,
identified
an
inverted
u-shaped
relationship
the
estradiol.
Additionally,
1.50%
-0.15,
3.18)
TT4,
whereas
males,
-1.77%
-4.08,
0.58)
TT4
-0.18
-0.33,
-0.03)
Some
early-to-mid
There
some
associations.
Future
studies
could
consider
how
these
findings
relate
pregnancy/birth
outcomes.
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(7), С. 3121 - 3143
Опубликована: Май 30, 2024
Environmental
impacts
of
the
industrial
revolution
necessitate
adoption
sustainable
practices
in
all
areas
development.
The
pharmaceutical
industry
faces
increasing
pressure
to
minimize
its
ecological
footprint
due
significant
contribution
environmental
pollution.
Over
past
two
decades,
cocrystals
have
received
immense
popularity
their
ability
optimize
critical
attributes
active
ingredients
and
presented
an
avenue
bring
improved
drug
products
market.
This
review
explores
potential
as
ecofriendly
alternative
traditional
solid
forms,
offering
a
approach
From
reducing
number
required
doses
improving
stability
actives,
from
eliminating
synthetic
operations
using
pharmaceutically
approved
chemicals,
use
continuous
solvent-free
manufacturing
methods
leveraging
published
data
on
safety
toxicology,
cocrystallization
contributes
sustainability
latest
trends
suggest
promising
role
bringing
novel
medicines
market,
which
has
been
further
fuelled
by
recent
guidance
major
regulatory
agencies.
