Journal of Hazardous Materials, Год журнала: 2022, Номер 446, С. 130665 - 130665
Опубликована: Дек. 28, 2022
Язык: Английский
Environmental Science & Technology, Год журнала: 2023, Номер 57(12), С. 4852 - 4862
Опубликована: Март 16, 2023
Inappropriate application of pesticides not only causes sub-lethal effects on ecosystem service providers but also reduces crop yield and quality. As a xenobiotic signal molecule, may interact with transduction receptors in crops, resulting oxidative damage even metabolic perturbations. We discovered that three neonicotinoid insecticides (NIs), namely, imidacloprid, thiamethoxam, clothianidin, at 0.06-0.12 kg ai/ha significantly inhibited the auxin pathway rice leaves, thereby reducing intracellular (IAA) content. Molecular simulation further confirmed NIs occupied binding site where transporter-like proteins 1 (LAX11) 2 (LAX12), which Thr253 Asn66 LAX11, as well Thr244 Asn57 LAX12, were bound to nitroguanidine via H-bonds. Meanwhile, LAX11 LAX12 interacted aromatic Moreover, phenylpropanoid biosynthesis was disturbed because pathway. Notably, peroxidase-coding genes downregulated maximum value greater than 10-fold, decreased antioxidant metabolites flavone (37.82%) lignin content (20.15%). Ultimately, biomass reduced by up 25.41% due decline IAA capacity. This study deeply explored molecular mechanism perturbations crops stressed pesticides, thus providing scientific basis for pesticide environmental risk assessment agricultural product safety.
Язык: Английский
Процитировано
53
The Science of The Total Environment, Год журнала: 2023, Номер 888, С. 164149 - 164149
Опубликована: Май 16, 2023
Язык: Английский
Процитировано
46
Chemosphere, Год журнала: 2024, Номер 362, С. 142678 - 142678
Опубликована: Июнь 21, 2024
Язык: Английский
Процитировано
22
Sensors and Actuators B Chemical, Год журнала: 2024, Номер 404, С. 135279 - 135279
Опубликована: Янв. 9, 2024
Язык: Английский
Процитировано
17
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(16), С. 8994 - 8994
Опубликована: Авг. 12, 2022
DNA methylation is an epigenetic mark that living beings have used in different environments. The MTases family catalyzes methylation. This process conserved from archaea to eukaryotes, fertilization every stage of development, and the early stages cancer metastasis. DNMTs has been classified into DNMT1, DNMT2, DNMT3. Each DNMT duplicated or deleted, having consequences on structure cellular function, resulting a evolutionary reaction are five kingdoms life: bacteria, protists, fungi, plants, animals. importance whether methylate not historical adaptation mammals discovered complex regulatory mechanisms develop another padlock genomic insurance stability. control expression involved diversity cell phenotypes associated with pathologies transcription deregulation. work focused methyltransferases, their biology, functions, new inhibitory reported. We also discuss approaches inhibit DNMTs, use non-coding RNAs nucleoside chemical compounds recent studies, biological, clinical, industry research.
Язык: Английский
Процитировано
35
Drug Metabolism Reviews, Год журнала: 2022, Номер 54(3), С. 282 - 298
Опубликована: Май 28, 2022
Uridine diphosphate sugar-utilizing glycosyltransferases (UGTs) are an enzyme superfamily that catalyzes glycosyl residues transfer from activated nucleotide sugars to acceptor molecules. In addition various endogenous compounds, numerous xenobiotics substrates of UGTs. As the glycosides formed generally less active/toxic and more hydrophilic than aglycones, UGTs effectively protect organisms potentially harmful xenobiotics. Therefore, increased UGT expression and/or activity improve protection organism may contribute development individuals become resistant certain While function in resistance human cancer cells chemotherapy is now well known, other have attracted much attention. This review was designed fill this knowledge gap by presenting complex information about role xenobiotic-resistance organisms. summarization evaluation available reveals play important defense against not only humans, but countless such as parasites, insects, plants. Moreover, many recent studies clearly show participation nematodes anthelmintics, insects insecticides, weeds herbicides humans drugs (not those used therapy also treatment epilepsy, psychiatric disorders, hypertension, hypercholesterolemia, HIV infection). Nevertheless, although contribution xenobiotic diverse has obvious, pieces remain missing, for example with regard mechanisms regulation.
Язык: Английский
Процитировано
34
Environment International, Год журнала: 2022, Номер 167, С. 107442 - 107442
Опубликована: Июль 30, 2022
Язык: Английский
Процитировано
33
Gene, Год журнала: 2022, Номер 834, С. 146613 - 146613
Опубликована: Май 25, 2022
Язык: Английский
Процитировано
29
Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 263, С. 115242 - 115242
Опубликована: Июль 11, 2023
Erythromycin (ERY) is a typical macrolide antibiotic with large production and extensive use on global scale. Detection of ERY in both freshwaters coaster seawaters, as well relatively high ecotoxicity have been documented. Notably, hormesis has reported several freshwater algae under stress, where growth was promoted at lower exposures but inhibited higher treatment levels. On the contrary, there limited information toxicity marine algae, hampering risk assessment waters. The presence may challenge current concept dose-response adopted chemical assessment. Whether how exposure to can induce dose-dependent remain virtually unknown, especially environmentally relevant concentrations. present study used model diatom Thalassiosira weissflogii (T. weissflogii) reveal its toxicological responses different biological levels decipher underlying mechanisms. Assessment multiple apical endpoints shows an evident promotion following concentration (1 µg/L), associated increased contents reactive oxygen species (ROS) chlorophyll-a (Chl-a), activated signaling pathways related ribosome biosynthesis translation, total soluble protein. By contrast, inhibition 750 2500 µg/L treatments attributed reduced viability, ROS formation, content protein, photosynthesis, perturbed involved xenobiotic metabolism, ribosome, metabolism amino acid, nitrogen metabolism. Measurements coupled de novo transcriptomics analysis applied study, systems biology approach, generate detailed mechanistic including sensitivity difference environmental
Язык: Английский
Процитировано
18
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(17), С. 9680 - 9690
Опубликована: Апрель 18, 2024
Plant pathogens have frequently shown multidrug resistance (MDR) in the field, often linked to efflux and sometimes metabolism of fungicides. To investigate potential role metabolic B. cinerea strains showing MDR, azoxystrobin-sensitive strain B05.10 -resistant Bc242 were treated with azoxystrobin. The degradation half-life azoxystrobin (9.63 days) was shorter than that (28.88 days). Azoxystrobin acid, identified as a metabolite, exhibited significantly lower inhibition rates on colony conidia (9.34 11.98%, respectively) higher expression levels 34 cytochrome P450s (P450s) 11 carboxylesterase genes (CarEs) compared according RNA-seq analysis. P450 Bcin_02g01260 Bcin_12g06380, along CarEs Bcin_12g06360 Saccharomyces cerevisiae, resulted reduced sensitivity various fungicides, including azoxystrobin, kresoxim-methyl, pyraclostrobin, trifloxystrobin, iprodione, carbendazim. Thus, mechanism MDR is mediated by CarE genes.
Язык: Английский
Процитировано
7