Screening androgen receptor agonists of fish species using machine learning and molecular model in NORMAN water-relevant list

Journal of Hazardous Materials, Год журнала: 2024, Номер 468, С. 133844 - 133844

Опубликована: Фев. 20, 2024

Язык: Английский

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Distinctively Different Effects of Perfluorobutanoic Acid and Perfluorononanoic Acid on Zebrafish Sex Differentiation and Androgen Receptor Activity

Environment & Health, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

With the prohibition of perfluorooctanoic acid (PFOA), emergence alternative perfluoroalkyl substances such as perfluorobutanonic (PFBA) and perfluorononanoic (PFNA) in various environmental matrices has led to concerns about their adverse effects on humans biota. This study aims investigate reproductive developmental toxicity PFBA PFNA by combined vivo, vitro, silico approaches. Examination juvenile zebrafish exposed at concentrations histopathology, sex hormone, gene expression revealed accelerated development toward males, while exposure during differentiation resulted feminization. In accordance with vivo results, activated androgen receptor (AR) signaling pathway, but inhibited it both prostate cancer cell proliferation luciferase reporter assays. Similarly, differential binding mode two chemicals AR was shown molecular docking analysis, exhibiting higher potency for agonist conformation favoring antagonistic conformation. Together, these results suggest that, exhibited similar activity PFOA, showed distinctive deserves particular attention further investigation.

Язык: Английский

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The exposure to Nandrolone changed the expression of genes associated with sexual differentiation and disrupted the levels of hormones in the hypothalamic-pituitary-gonadal (HPG) axis, ultimately inducing male differentiation in zebrafish (Danio rerio)

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126156 - 126156

Опубликована: Март 1, 2025

Язык: Английский

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Function of Foxl2 and Dmrt1 proteins during gonadal differentiation in the olive flounder Paralichthys olivaceus

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 215, С. 141 - 154

Опубликована: Июнь 16, 2022

Язык: Английский

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Norethindrone suppress the germ cell development via androgen receptor resulting in male bias

Aquatic Toxicology, Год журнала: 2023, Номер 261, С. 106604 - 106604

Опубликована: Июнь 8, 2023

Язык: Английский

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The food safety assessment of all-female common carp (Cyprinus carpio) (cyp17a1+/−;XX genotype) generated using genome editing technology

Food and Chemical Toxicology, Год журнала: 2023, Номер 181, С. 114103 - 114103

Опубликована: Окт. 16, 2023

There are several technical challenges and public issues concerning genome editing applications before they become viable in commercial aquaculture. Recently, we developed a novel strategy to generate all-female (AF) common carp, which exhibited growth advantage over the control using genetic through single gene-targeting manipulation. Here, found that body weight of AF carp was higher by 22.58% than carp. Because genotype cyp17a1+/-;XX, contents sex steroids were normally synthesized, as comparable female To evaluate food safety Wistar rats fed diet containing (control, C) or at an incorporation rate 5, 10 20% (w/w) for 90 days. Compared with those no significant difference weight, intake, feed conversion ratio, hematology, serum biochemistry, urine test, relative organ gross necropsy, histopathological examination. This is first assessment farmed fish strain cultured CRISPR/Cas9, will further advance fishery development genome-edited animals.

Язык: Английский

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Enhancing Ligand-Based Virtual Screening with 3D Shape Similarity via a Distance-Aware Transformer Model

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Ноя. 17, 2023

Abstract Following the assumption that chemically similar molecules exhibit biologcial properties, ligand-based virtual screening can be a valuable starting point in drug discovery projects. While 2D-based similarity metrics generally focus on scaffolds or substructures, 3D-based methods capture shape of molecule, allowing for identification compounds with different scaffolds. We recently published proof-of-concept study which demonstrated how Transformer model adapted to preserve 2D similarities latent space form Euclidean distances. In this work, we extend research and prove approach 3D similarities. use pharmacophore-based as measure. show is able enrich predicted most hits are indeed space. Whereas classical pharmacophore- shape-based rely expensive alignment processes, our approach, identify directly by distances This enables first time ultra-large databases high efficiency.

Язык: Английский

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The Effects of Hormones on The eyes and Blurry Vision in Rabbits, Kittens, Rats, and Humans

Egyptian Journal of Veterinary Science, Год журнала: 2024, Номер 56(1), С. 241 - 255

Опубликована: Май 8, 2024

This review explains that various hormones are chemical messengers affecting eyesight and vision. Several factors, including side effects, hormonal changes during pregnancy, pharmaceuticals, which include hormone replacement treatment or oral contraceptives, can cause blurred Furthermore, like thyroid hormones, melatonin, estrogen, testosterone, cortisol, insulin, growth hormone, prostaglandins, adrenaline, noradrenaline affect the function of eyes vision, their imbalances abnormalities in blurry Consequently, (G.H.) plays an important role visual organs birds, reptiles, mammals. The importance ocular function, both under normal physiological conditions abnormal pathological conditions, appears significant. In addition, stress impact levels potentially lead to vision problems. Cortisol is a secreted times has been studied wild domestic cats. Hence, medical such as diabetes systems through levels. So, neurotransmitters dopamine, noradrenaline, serotonin have inhibitory effect on cortex. Additionally, they inhibit neurotransmitter acetylcholine. When excitations induced for extended periods, this result inhibition. results show significant differences between species could abilities. conclusion, play maintaining health regulating any irregularities dysfunctions may arise these systems. Thus, animals with humans experience due effects eyes.

Язык: Английский

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PFAS-Biomolecule Interactions: Case Study Using Asclepios Nodes and Automated Workflows in KNIME for Drug Discovery and Toxicology

Methods in molecular biology, Год журнала: 2024, Номер unknown, С. 393 - 441

Опубликована: Сен. 23, 2024

Язык: Английский

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