Screening androgen receptor agonists of fish species using machine learning and molecular model in NORMAN water-relevant list
Xiao-Bing Long,
Chong-Rui Yao,
Siying Li
и другие.
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
468, С. 133844 - 133844
Опубликована: Фев. 20, 2024
Язык: Английский
Distinctively Different Effects of Perfluorobutanoic Acid and Perfluorononanoic Acid on Zebrafish Sex Differentiation and Androgen Receptor Activity
Environment & Health,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
With
the
prohibition
of
perfluorooctanoic
acid
(PFOA),
emergence
alternative
perfluoroalkyl
substances
such
as
perfluorobutanonic
(PFBA)
and
perfluorononanoic
(PFNA)
in
various
environmental
matrices
has
led
to
concerns
about
their
adverse
effects
on
humans
biota.
This
study
aims
investigate
reproductive
developmental
toxicity
PFBA
PFNA
by
combined
vivo,
vitro,
silico
approaches.
Examination
juvenile
zebrafish
exposed
at
concentrations
histopathology,
sex
hormone,
gene
expression
revealed
accelerated
development
toward
males,
while
exposure
during
differentiation
resulted
feminization.
In
accordance
with
vivo
results,
activated
androgen
receptor
(AR)
signaling
pathway,
but
inhibited
it
both
prostate
cancer
cell
proliferation
luciferase
reporter
assays.
Similarly,
differential
binding
mode
two
chemicals
AR
was
shown
molecular
docking
analysis,
exhibiting
higher
potency
for
agonist
conformation
favoring
antagonistic
conformation.
Together,
these
results
suggest
that,
exhibited
similar
activity
PFOA,
showed
distinctive
deserves
particular
attention
further
investigation.
Язык: Английский
The exposure to Nandrolone changed the expression of genes associated with sexual differentiation and disrupted the levels of hormones in the hypothalamic-pituitary-gonadal (HPG) axis, ultimately inducing male differentiation in zebrafish (Danio rerio)
Environmental Pollution,
Год журнала:
2025,
Номер
unknown, С. 126156 - 126156
Опубликована: Март 1, 2025
Язык: Английский
Function of Foxl2 and Dmrt1 proteins during gonadal differentiation in the olive flounder Paralichthys olivaceus
International Journal of Biological Macromolecules,
Год журнала:
2022,
Номер
215, С. 141 - 154
Опубликована: Июнь 16, 2022
Язык: Английский
Norethindrone suppress the germ cell development via androgen receptor resulting in male bias
Aquatic Toxicology,
Год журнала:
2023,
Номер
261, С. 106604 - 106604
Опубликована: Июнь 8, 2023
Язык: Английский
The food safety assessment of all-female common carp (Cyprinus carpio) (cyp17a1+/−;XX genotype) generated using genome editing technology
Food and Chemical Toxicology,
Год журнала:
2023,
Номер
181, С. 114103 - 114103
Опубликована: Окт. 16, 2023
There
are
several
technical
challenges
and
public
issues
concerning
genome
editing
applications
before
they
become
viable
in
commercial
aquaculture.
Recently,
we
developed
a
novel
strategy
to
generate
all-female
(AF)
common
carp,
which
exhibited
growth
advantage
over
the
control
using
genetic
through
single
gene-targeting
manipulation.
Here,
found
that
body
weight
of
AF
carp
was
higher
by
22.58%
than
carp.
Because
genotype
cyp17a1+/-;XX,
contents
sex
steroids
were
normally
synthesized,
as
comparable
female
To
evaluate
food
safety
Wistar
rats
fed
diet
containing
(control,
C)
or
at
an
incorporation
rate
5,
10
20%
(w/w)
for
90
days.
Compared
with
those
no
significant
difference
weight,
intake,
feed
conversion
ratio,
hematology,
serum
biochemistry,
urine
test,
relative
organ
gross
necropsy,
histopathological
examination.
This
is
first
assessment
farmed
fish
strain
cultured
CRISPR/Cas9,
will
further
advance
fishery
development
genome-edited
animals.
Язык: Английский
PFAS-Biomolecule Interactions: Case Study Using Asclepios Nodes and Automated Workflows in KNIME for Drug Discovery and Toxicology
Methods in molecular biology,
Год журнала:
2024,
Номер
unknown, С. 393 - 441
Опубликована: Сен. 23, 2024
Язык: Английский
Enhancing Ligand-Based Virtual Screening with 3D Shape Similarity via a Distance-Aware Transformer Model
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 17, 2023
Abstract
Following
the
assumption
that
chemically
similar
molecules
exhibit
biologcial
properties,
ligand-based
virtual
screening
can
be
a
valuable
starting
point
in
drug
discovery
projects.
While
2D-based
similarity
metrics
generally
focus
on
scaffolds
or
substructures,
3D-based
methods
capture
shape
of
molecule,
allowing
for
identification
compounds
with
different
scaffolds.
We
recently
published
proof-of-concept
study
which
demonstrated
how
Transformer
model
adapted
to
preserve
2D
similarities
latent
space
form
Euclidean
distances.
In
this
work,
we
extend
research
and
prove
approach
3D
similarities.
use
pharmacophore-based
as
measure.
show
is
able
enrich
predicted
most
hits
are
indeed
space.
Whereas
classical
pharmacophore-
shape-based
rely
expensive
alignment
processes,
our
approach,
identify
directly
by
distances
This
enables
first
time
ultra-large
databases
high
efficiency.
Язык: Английский
The Effects of Hormones on The eyes and Blurry Vision in Rabbits, Kittens, Rats, and Humans
Imtithal Mohammed,
Hala O. Adnan
Egyptian Journal of Veterinary Science,
Год журнала:
2024,
Номер
56(1), С. 241 - 255
Опубликована: Май 8, 2024
This
review
explains
that
various
hormones
are
chemical
messengers
affecting
eyesight
and
vision.
Several
factors,
including
side
effects,
hormonal
changes
during
pregnancy,
pharmaceuticals,
which
include
hormone
replacement
treatment
or
oral
contraceptives,
can
cause
blurred
Furthermore,
like
thyroid
hormones,
melatonin,
estrogen,
testosterone,
cortisol,
insulin,
growth
hormone,
prostaglandins,
adrenaline,
noradrenaline
affect
the
function
of
eyes
vision,
their
imbalances
abnormalities
in
blurry
Consequently,
(G.H.)
plays
an
important
role
visual
organs
birds,
reptiles,
mammals.
The
importance
ocular
function,
both
under
normal
physiological
conditions
abnormal
pathological
conditions,
appears
significant.
In
addition,
stress
impact
levels
potentially
lead
to
vision
problems.
Cortisol
is
a
secreted
times
has
been
studied
wild
domestic
cats.
Hence,
medical
such
as
diabetes
systems
through
levels.
So,
neurotransmitters
dopamine,
noradrenaline,
serotonin
have
inhibitory
effect
on
cortex.
Additionally,
they
inhibit
neurotransmitter
acetylcholine.
When
excitations
induced
for
extended
periods,
this
result
inhibition.
results
show
significant
differences
between
species
could
abilities.
conclusion,
play
maintaining
health
regulating
any
irregularities
dysfunctions
may
arise
these
systems.
Thus,
animals
with
humans
experience
due
effects
eyes.
Язык: Английский