International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(10), С. 5583 - 5583
Опубликована: Май 17, 2022
RoundUp®
(RUp)
is
a
comercial
formulation
containing
glyphosate
(N-(phosphono-methyl)
glycine),
and
the
world’s
leading
wide-spectrum
herbicide
used
in
agriculture.
Supporters
of
broad
use
glyphosate-based
herbicides
(GBH)
claim
they
are
innocuous
to
humans,
since
active
compound
acts
on
inhibition
enzymes
which
absent
human
cells.
However,
neurotoxic
effects
GBH
have
already
been
shown
many
animal
models.
Further,
these
formulations
were
disrupt
microbiome
different
species.
Here,
we
investigated
lifelong
exposure
low
doses
GBH-RUp
gut
environment,
including
morphological
changes.
We
also
aimed
determine
whether
could
harm
developing
brain
lead
behavioral
changes
adult
mice.
To
this
end,
animals
exposed
drinking
water
from
pregnancy
adulthood.
GBH-RUp-exposed
mice
had
no
cognitive
function,
but
developed
impaired
social
behavior
increased
repetitive
behavior.
GBH-Rup-exposed
showed
an
activation
phagocytic
cells
(Iba-1–positive)
cortical
tissue.
caused
mucus
production
infiltration
plama
(CD138-positive),
with
reduction
Long-term
induced
intestinal
integrity,
as
demonstrated
by
altered
expression
tight
junction
effector
proteins
(ZO-1
ZO-2)
change
distribution
syndecan-1
proteoglycan.
The
led
composition,
crucial
for
establishment
barrier.
Altogether,
our
findings
suggest
that
long-term
leads
functional
gut,
correlate
similar
those
observed
patients
neurodevelopmental
disorders.
Environmental Science & Technology,
Год журнала:
2022,
Номер
57(46), С. 17774 - 17785
Опубликована: Окт. 21, 2022
Pregnancy
and
infancy
are
vulnerable
times
for
detrimental
environmental
exposures.
However,
the
exposure
situation
of
microplastics
(MPs)
mother-infant
pairs
adverse
health
effect
MPs
largely
unknown.
Therefore,
we
explored
MP
in
placentas
meconium
samples,
potential
correlation
with
microbiota
meconium.
A
total
18
were
effectively
recruited
from
Shanghai,
China.
The
study
required
pregnant
women
to
provide
samples.
An
Agilent
8700
laser
infrared
imaging
spectrometer
(LDIR)
was
applied
identify
MPs.
Microbiota
detection
identified
by
16S
rRNA
sequencing.
Sixteen
types
found
all
matrices,
polyamide
(PA)
polyurethane
(PU)
major
identified.
detected
samples
a
size
20-50
μm
more
than
76.46%.
At
phylum
level,
both
placenta
mainly
composed
Proteobacteria,
Bacteroidota,
Firmicutes.
We
also
some
significant
differences
between
β-diversity
gut
composition.
Additionally,
polystyrene
inversely
related
Chao
index
microbiota.
Polyethylene
consistently
correlated
several
genera
MPs,
PA,
PU
impacted
In
conclusion,
ubiquitous
indicating
wide
infants.
Moreover,
our
findings
may
support
link
high
concentration
there
associations
particle
50-100
Environmental Sciences Europe,
Год журнала:
2024,
Номер
36(1)
Опубликована: Фев. 6, 2024
Abstract
Glyphosate
(GLY),
the
most
widely
used
herbicide
active
ingredient
(AI)
in
world,
is
frequently
detected
aquatic
environments
where
it
can
affect
non-target
organisms.
Globally,
more
than
2000
commercial
GLY-based
herbicides
(GBHs)
are
to
control
weeds.
Non-target
organisms
exposed
complex
pesticide
formulations
under
real
environmental
conditions,
but
co-formulants
contained
GBHs
classified
as
so-called
inert
and
inactive
ingredients
terms
of
their
biological
effects.
The
main
objective
this
comprehensive
review
compile
results
ecotoxicological
studies
on
side-effects
GLY,
GBHs,
formulating
agents.
Based
demonstrated
for
a
variety
plant
animal
organisms,
oxidative
stress
appears
be
major
trigger
these
adverse
effects,
affecting
integrity
DNA
other
biochemical
functions.
Furthermore,
there
evidence
impairment
various
physiological
behavioral
Adverse
effects
GLY
have
been
observed
even
at
very
low
concentrations.
There
also
differences
sensitivity
tested,
with
similar
lifestyles,
habitats
or
identical
taxa.
typically
investigate
short-term
single
exposure
GLY/GBH
species,
whilst
reality
multiple
applications
together
pesticides
common
during
cropping
cycle.
Moreover,
interactions
between
GLY/GBHs
contaminants
rarely
studied.
Higher
toxicity
compared
alone
has
often
observed,
demonstrating
that
highly
toxic
own
markedly
increase
GBH
formulation.
possible
impurities
such
heavy
metals,
cause
additional
problems
environment
food
safety.
widespread
massive
use
leads
increased
hazards.
In
addition,
need
revision
risk
assessment
system
emphasized.
According
studies,
current
pollution
by
problematic
cannot
considered
environmentally
sustainable.
It
is,
therefore,
necessary
least
tighten
permitted
forms
use.
Water Biology and Security,
Год журнала:
2022,
Номер
1(3), С. 100040 - 100040
Опубликована: Май 4, 2022
Microplastic
pollution
has
become
an
increasingly
important
environmental
issue
worldwide
in
recent
years
because
of
its
ubiquitous
presence
different
media
and
potential
to
affect
the
health
organisms
ecosystems.
Aquaculture
contributes
significantly
world's
food
production
nutritional
supply,
especially
developing
countries.
Widespread
occurrence
microplastics
aquaculture
systems
raised
great
concern
regarding
safety
issues
products.
China
is
a
world
leader
production,
with
freshwater
accounting
for
59.1%
total
2020.
Therefore,
this
review
mainly
focuses
on
research
progress
related
microplastic
China.
Results
from
literature
show
that
are
present
at
abundances
comparable
natural
waterbodies
Microplastics
can
be
ingested
remain
body
Exposure
adversely
aquatic
ecosystem
functions.
However,
risks
real
environment
uncertain.
Consumption
products
not
major
pathway
human
exposure
microplastics.
To
provide
scientific
guidance
governmental
decision-making
control,
future
work
should
focus
toxicological
methodology
understanding
impacts
community
levels.
