Developmental defects and potential mechanisms in F1 generation of parents exposed to difenoconazole at different life stages of zebrafish (Danio rerio) DOI

Yiming Chang,

Huimin Fu, Haitao Yu

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 883, С. 163529 - 163529

Опубликована: Апрель 15, 2023

Язык: Английский

Toxicity effects of pesticides based on zebrafish (Danio rerio) models: Advances and perspectives DOI
Jiajia Cui,

Sinuo Tian,

Yuntong Gu

и другие.

Chemosphere, Год журнала: 2023, Номер 340, С. 139825 - 139825

Опубликована: Авг. 14, 2023

Язык: Английский

Процитировано

33

Long-term exposure of zebrafish (Danio rerio) to Cr(VI): Reproductive toxicity and neurotoxicity DOI
Lei Zhao,

Hengxuan Duan,

Yihan Liu

и другие.

Regional Studies in Marine Science, Год журнала: 2024, Номер 74, С. 103559 - 103559

Опубликована: Апрель 30, 2024

Язык: Английский

Процитировано

14

Pathway Elucidation and Key Enzymatic Processes in the Biodegradation of Difenoconazole by Pseudomonas putida A-3 DOI
Yi Zhou,

Liping Wang,

Jing Sui

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

The extensive agricultural use of the fungicide difenoconazole (DIF) and its associated toxicity increasingly damage ecosystems human health. Thus, an urgent need is to develop environmentally friendly technological approaches capable effectively removing DIF residues. In this study, strain Pseudomonas putida A-3 was isolated for first time which can degrade efficiently. After optimization degradation conditions, rate reached 75.98%. Moreover, a new pathway, including hydroxylation, hydrolysis, dechlorination, ether bond breaking. acute chronic products assessed using ECOSAR software showed lower than parent compound. Furthermore, remarkably accelerated in contaminated water-sediment systems. We successfully predicted six potential key enzymes based on results whole genome sequencing, RT-qPCR, molecular docking. Overall, revealed novel pathways biodegradation provide strong candidate bioremediation residue-polluted environments.

Язык: Английский

Процитировано

2

The effect of abamectin exposure on gametogenesis in zebrafish DOI Creative Commons
Sevda Bağdatli, Nazan Deniz YÖN ERTUĞ

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 16, 2025

Today, pesticides are widely used to enhance agricultural yield mixed with soil and water, creating significant environmental pollution. The extensive use of insecticides for pest control has made this issue more pronounced. Abamectin, a key member the avermectin family, is as an insecticide antihelminthic agent in agriculture. It active effective pesticide, particularly preferred combating pests such aphids red spider mites. dosage frequency its vary depending on target plant species organism. For example, abamectin-based products 18 g/L EC formulation apple orchards typically recommended at 10 ml/100 L water Although significantly below application levels, low dose 0.75 µg L⁻1 our study demonstrated effects that cannot be overlooked. However, it can contaminate aquatic environments, posing harmful organisms. Studies indicate abamectin exposure may lead serious health issues, showing toxic reproductive toxicity species. Examining abamectin's testicular tissue revealed hypertrophy Sertoli cells group exposed abamectin. Apoptotic were observed groups 1.5 L⁻1. At same time, pyknotic structures, disruption seminiferous tubules, interstitial fibrosis, atrophic appearance identified across all groups, severity increasing dose-dependently. Analysis ovarian distortion zona radiata Moreover, thickening radiata, vacuolization, formation degenerated follicles, nuclear observed, these pathological alterations exacerbating dose-dependent manner. Like many studies involving zebrafish, research crucial assessing potential pose risks human health. This examined histopathological varying doses (0.75 L⁻1, 3 L⁻1) zebrafish gonads after 96 h exposure. Using standard histological techniques, samples prepared stained H&E under light microscope. Statistical analyses conducted using SPSS 23. normality data was assessed Shapiro–Wilk test. One-way ANOVA Tukey post-hoc tests normally distributed while Kruskal–Wallis Dunnett's T3 applied non-normally groups. All performed 95% confidence interval significance level p > 0.05.

Язык: Английский

Процитировано

2

Intergenerational reproductive toxicity of parental exposure to prothioconazole and its metabolite on offspring and epigenetic regulation associated with DNA methylation in zebrafish DOI Creative Commons

Sinuo Tian,

Wei Sun, Xiaoxuan Sun

и другие.

Environment International, Год журнала: 2023, Номер 173, С. 107830 - 107830

Опубликована: Фев. 15, 2023

Prothioconazole (PTC) is a widely used agricultural fungicide, and its parent metabolite prothioconazole-desthio (dPTC) have been detected in diverse environmental media. This study was aimed at investigating the gender-dependent effects on adult zebrafish reproduction intergenerational offspring development following parental exposure to PTC dPTC. The results showed that after (F0) exposed 0.5 10 μg/L dPTC for 21 days, fertility gametogenesis of female were decreased more significantly than male zebrafish. After that, three fecundity tests conducted period explore endpoints F1 embryos/larvae without further treatment with exposure. However, did lead abnormal embryos, including delayed hatching, shortened body length, significant changes locomotor behavior. These related expression sex hormones regulation DNA methylation F0 fish. In word, this interference sex-dependent reproductive toxicity zebrafish, which may be passed next generation through epigenetic modification involving methylation, resulting alternations growth phenotype offspring.

Язык: Английский

Процитировано

21

Embryonic benzophenone-3 exposure inhibited fertility in later-life female zebrafish and altered developmental morphology in offspring embryos DOI
Junyan Tao, Qinyuan Yang,

Min Jing

и другие.

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(17), С. 49226 - 49236

Опубликована: Фев. 11, 2023

Язык: Английский

Процитировано

15

Triazole fungicides exert neural differentiation alteration through H3K27me3 modifications: In vitro and in silico study DOI
Tingting Ku,

Xin Tan,

Yutong Liu

и другие.

Journal of Hazardous Materials, Год журнала: 2023, Номер 459, С. 132225 - 132225

Опубликована: Авг. 4, 2023

Язык: Английский

Процитировано

14

“Fishcide” effect of the fungicide difenoconazole in freshwater fish (Labeo rohita): A multi-endpoint approach DOI

Bojan Nataraj,

Devan Hemalatha, Guilherme Malafaia

и другие.

The Science of The Total Environment, Год журнала: 2022, Номер 857, С. 159425 - 159425

Опубликована: Окт. 14, 2022

Язык: Английский

Процитировано

22

Mechanisms regarding respiratory toxicity triggered by accumulation of ROS in carp exposed to difenoconazole DOI

Huimiao Feng,

Huizhen Chen,

Jingchao Qiang

и другие.

Pesticide Biochemistry and Physiology, Год журнала: 2023, Номер 191, С. 105343 - 105343

Опубликована: Янв. 14, 2023

Язык: Английский

Процитировано

12

Immunoprotective effect of silybin through blocking p53-driven caspase-9-Apaf-1-Cyt c complex formation and immune dysfunction after difenoconazole exposure in carp spleen DOI

Enzhuang Pan,

Xin Yue, Xueqing Li

и другие.

Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(13), С. 19396 - 19408

Опубликована: Фев. 15, 2024

Язык: Английский

Процитировано

5