Microplastics and Oxidative Stress—Current Problems and Prospects

Antioxidants, Год журнала: 2024, Номер 13(5), С. 579 - 579

Опубликована: Май 8, 2024

Microplastics (MPs) are plastic particles between 0.1 and 5000 µm in size that have attracted considerable attention from the scientific community general public, as they threaten environment. contribute to various harmful effects, including lipid peroxidation, DNA damage, activation of mitogen-activated protein kinase pathways, cell membrane breakages, mitochondrial dysfunction, lysosomal defects, inflammation, apoptosis. They affect cells, tissues, organs, overall health, potentially contributing conditions like cancer cardiovascular disease. pose a significant danger due their widespread occurrence food. In recent years, information has emerged indicating MPs can cause oxidative stress (OS), known factor accelerating aging organisms. This comprehensive evaluation exposed notable variability reported connection OS. work aims provide critical review whether harmfulness constitute environmental contaminants may result OS through analysis research existing literature, well an assessment characteristics causing Additionally, article covers analytical methodology used this field. The conclusions point necessity for further into effects on

Язык: Английский

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Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens

Journal of Zhejiang University SCIENCE B, Год журнала: 2024, Номер 25(3), С. 233 - 243

Опубликована: Март 1, 2024

Язык: Английский

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Luteolin enhanced antioxidant capability and induced pyroptosis through NF-κB/NLRP3/Caspase-1 in splenic lymphocytes exposure to ammonia

The Science of The Total Environment, Год журнала: 2024, Номер 919, С. 170699 - 170699

Опубликована: Фев. 5, 2024

Язык: Английский

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Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation

Pharmacological Research, Год журнала: 2024, Номер 206, С. 107258 - 107258

Опубликована: Июнь 21, 2024

Several cardiovascular illnesses are associated with aberrant activation of cellular pyroptosis, ferroptosis, necroptosis, cuproptosis, disulfidptosis and macrophage polarisation as hallmarks contributing to vascular damage abnormal cardiac function. Meanwhile, these three novel forms dysfunction closely related mitochondrial homeostasis. Mitochondria the main organelles that supply energy maintain Mitochondrial stability is maintained through a series regulatory pathways, such fission, fusion mitophagy. Studies have shown (e.g., impaired dynamics mitophagy) promotes ROS production, leading oxidative stress, which induces M1 phenotypic polarisation. Therefore, an in-depth knowledge dynamic regulation mitochondria during necessary understand disease development. This paper systematically summarises impact changes in mitophagy on regulating dysfunctions promote understanding pathogenesis diseases provide corresponding theoretical references for treating diseases.

Язык: Английский

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AMPK–a key factor in crosstalk between tumor cell energy metabolism and immune microenvironment?

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Май 18, 2024

Abstract Immunotherapy has now garnered significant attention as an essential component in cancer therapy during this new era. However, due to immune tolerance, immunosuppressive environment, tumor heterogeneity, escape, and other factors, the efficacy of immunotherapy been limited with its application very small population size. Energy metabolism not only affects progression but also plays a crucial role escape. Tumor cells are more metabolically active need energy nutrients maintain their growth, which causes surrounding lack glucose, oxygen, nutrients, result decreased cell activity increased cells. On hand, utilize multiple metabolic pathways, for instance, cellular respiration, oxidative phosphorylation pathways normal function. Studies have shown that there is difference expenditure resting activated states. Notably, competitive uptake glucose main cause impaired T Conversely, glutamine competition often activation most transformation CD4 + into inflammatory subtypes. Excessive metabolite lactate impairs function NK Furthermore, PGE2 inhibits response by inhibiting Th1 differentiation, B function, activation. Additionally, tumor-suppressive M1 macrophages cancer-promoting M2 influenced metabolism. Therefore, vital factor involved reconstruction microenvironment. Noteworthy does program affect antigen presentation recognition cells, own functions, ultimately leading changes Metabolic intervention can improve tumors, increase immunogenicity thereby expanding who benefit from immunotherapy. Consequently, identifying crosstalk molecules link microenvironment would be promising anti-tumor strategy. AMPK (AMP-activated protein kinase) ubiquitous serine/threonine kinase eukaryotes, serving central regulator pathways. The sequential associated signaling cascades profoundly impacts dynamic alterations bioenergetics. By modulating responses, exerts influence on development, while playing pivotal regulating AMPK-mediated facilitates recruitment (TIME), impeding tumorigenesis, progression, metastasis. AMPK, between homeostasis, bioenergetics, immunity, will impact treatment management oncology patients. That being summarized, objective review pinpoint provide guidance development strategies.

Язык: Английский

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Enhancing the aging of polystyrene microplastics through a flow-through electrochemical membrane system: Mechanism of confinement effect

Journal of Hazardous Materials, Год журнала: 2025, Номер 488, С. 137478 - 137478

Опубликована: Фев. 3, 2025

Язык: Английский

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The histopathological and functional consequences of microplastic exposure

Deleted Journal, Год журнала: 2025, Номер 7(1)

Опубликована: Янв. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Язык: Английский

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ROS and DRP1 interactions accelerate the mitochondrial injury induced by polystyrene nanoplastics in human liver HepG2 cells

Chemico-Biological Interactions, Год журнала: 2023, Номер 379, С. 110502 - 110502

Опубликована: Апрель 19, 2023

Язык: Английский

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Cannabidiol Alleviates Perfluorooctanesulfonic Acid-Induced Cardiomyocyte Apoptosis by Maintaining Mitochondrial Dynamic Balance and Energy Metabolic Homeostasis

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(14), С. 5450 - 5462

Опубликована: Апрель 3, 2023

Perfluorooctanesulfonic acid (PFOS), a fluorine-containing organic compound, can be widely detected in the environment and living organisms. Accumulating evidence has shown that PFOS breaks through different biological barriers resulting cardiac toxicity, but underlying molecular mechanisms remain unclear. Cannabidiol (CBD) is nonpsychoactive cannabinoid without potential adverse cardiotoxicity antioxidant anti-inflammatory properties reduce multiorgan damage dysfunction. For these reasons, aim of this study was to research how caused heart injury whether CBD could attenuate PFOS-induced injury. Mice were fed (5 mg/kg) and/or (10 vivo. In vitro, H9C2 cells intervened with (200 μM) μM). After exposure, oxidative stress levels mRNA protein expression apoptosis-related markers increased distinctly, accompanied by mitochondrial dynamic imbalance energy metabolism disorders mouse cells. Moreover, terminal deoxynucleotidyl transferase dUTP nick end labeling staining, acridine orange/ethidium bromide staining Hoechst 33258 signaled number apoptotic after exposure PFOS. Noteworthy, simultaneous treatment alleviated series damages PFOS-mediated stress. Our results demonstrated alleviate dynamics disorder causing cardiomyocyte apoptosis improving capacity, suggesting may represent novel cardioprotective strategy against cardiotoxicity. findings facilitate understanding cardiotoxic effects important role protecting health.

Язык: Английский

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Polystyrene microplastics induce myocardial inflammation and cell death via the TLR4/NF-κB pathway in carp

Fish & Shellfish Immunology, Год журнала: 2023, Номер 135, С. 108690 - 108690

Опубликована: Март 21, 2023

Язык: Английский

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