Abstract
Heavy
metal
ions
(HMIs),
particularly
Hg
2+
,
Fe
Pb
and
Cd
are
toxic
to
biological
systems.
These
HMIs
display
a
wide
distribution
in
aqueous
systems,
due
their
bioaccumulation
tendency,
prevalence,
even
at
very
low
concentrations,
results
serious
health
issues
humans.
This
warrants
the
availability
of
easily
affordable,
reliable,
quick,
sensitive
approaches
for
real‐time
monitoring
concentration
environments.
Herein,
we
present
synthesis
novel
hydrazone
functionality‐based
chromogenic
probe
that
ensures
selective
spectrophotometric
sensing
HMIs.
More
specifically,
3‐(2‐(2,4‐dinitrophenyl)
hydrazono)
Penta‐1,4‐diene‐1,5‐diyl)
diphenol
referred
as
HZ
MS
through
two‐step
approach
via
low‐cost
precursors
viz.
Salicaldehyde,
acetone,
2,
4‐dinitrophenyl
hydrazine
(2,
4‐DNP)
is
presented.
The
unique
functionality
as‐synthesized
HZ,
well‐characterized
spectroscopic
approaches,
demonstrated
facilitate
with
detection
limits
0.74
μM,
1.46
0.75
nM
respectively.
Importantly
response
be
nature
HMI,
which
does
ensure
specification
chosen
ability
well
within
ranges
include
WHO‐recommended
safe
concentrations
these
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(23), С. 14562 - 14562
Опубликована: Ноя. 23, 2022
Attention
has
been
paid
to
the
early
diagnosis
of
Alzheimer's
disease,
due
maximum
benefit
acquired
from
early-stage
intervention
and
treatment.
However,
sensing
techniques
primarily
depended
upon
for
neuroimaging
immunological
assays
detection
AD
biomarkers
are
expensive,
time-consuming
instrument
dependent.
Here,
we
developed
a
multichannel
fluorescent
tongue
consisting
four
dyes
GO
through
electrostatic
π-π
interaction.
The
array
distinguished
multiple
aggregation
states
1
µM
Aβ40/Aβ42
with
100%
prediction
accuracy
via
10-channel
signal
outputs,
illustrating
rationality
design.
Screening
vital
sensor
elements
simplified
optimization
system
was
achieved
by
machine
learning
algorithms.
Moreover,
our
able
detect
in
serum,
demonstrating
great
potential
diagnosing
diseases.
Abstract
Heavy
metal
ions
(HMIs),
particularly
Hg
2+
,
Fe
Pb
and
Cd
are
toxic
to
biological
systems.
These
HMIs
display
a
wide
distribution
in
aqueous
systems,
due
their
bioaccumulation
tendency,
prevalence,
even
at
very
low
concentrations,
results
serious
health
issues
humans.
This
warrants
the
availability
of
easily
affordable,
reliable,
quick,
sensitive
approaches
for
real‐time
monitoring
concentration
environments.
Herein,
we
present
synthesis
novel
hydrazone
functionality‐based
chromogenic
probe
that
ensures
selective
spectrophotometric
sensing
HMIs.
More
specifically,
3‐(2‐(2,4‐dinitrophenyl)
hydrazono)
Penta‐1,4‐diene‐1,5‐diyl)
diphenol
referred
as
HZ
MS
through
two‐step
approach
via
low‐cost
precursors
viz.
Salicaldehyde,
acetone,
2,
4‐dinitrophenyl
hydrazine
(2,
4‐DNP)
is
presented.
The
unique
functionality
as‐synthesized
HZ,
well‐characterized
spectroscopic
approaches,
demonstrated
facilitate
with
detection
limits
0.74
μM,
1.46
0.75
nM
respectively.
Importantly
response
be
nature
HMI,
which
does
ensure
specification
chosen
ability
well
within
ranges
include
WHO‐recommended
safe
concentrations
these
